D-Pyroglutamic Acid

Name: D-Pyroglutamic Acid
Brand: Vaqora Chemicals
SKU: VQ-038996

About D-Pyroglutamic Acid

D-Pyroglutamic Acid (CAS 4042-36-8) is an impurity of Allopurinol offered by Vaqora Chemicals. Its molecular formula is C5H7NO3 and its molecular weight is 129.11 g/mol. Its systematic (IUPAC) name is (2R)-5-oxopyrrolidine-2-carboxylic acid. Alternative names: (R)-(+)-2-Pyrrolidone-5-carboxylic acid and 5-oxo-D-proline.

It is supplied as a solid. Reference materials should be stored sealed and away from light and moisture, as specified on the accompanying COA. The GHS classification uses the signal word “Warning”, so appropriate gloves, eye protection and ventilation are recommended.

This Allopurinol impurity supports analytical method development and validation (AMV), batch release testing and the impurity sections of ANDA and DMF filings. It is used across pharmaceutical manufacturing and academic and industrial research.

Standard pack sizes are 10 mg, 25 mg, 50 mg and 100 mg, and every batch ships with a Certificate of Analysis (COA) and we export worldwide.

Typical applications

Analytical method development
Method validation (AMV)
QC release testing
ANDA / DMF filings

Industries

Related to Allopurinol

View every impurity, metabolite and intermediate we list for Allopurinol.

Allopurinol impurities

Specifications & identifiers

Chemical identifiers
Product name	D-Pyroglutamic Acid
Catalogue No.	VQ-038996
CAS Number	4042-36-8
IUPAC name	(2R)-5-oxopyrrolidine-2-carboxylic acid
Molecular formula	C₅H₇NO₃
Molecular weight	129.11 g/mol
Exact mass	129.0426
Grade	Reference Standard
HSN code	38229090
InChIKey	ODHCTXKNWHHXJC-GSVOUGTGSA-N
SMILES	C1CC(=O)N[C@H]1C(=O)O
PubChem CID	439685

Physical properties
Physical form	Solid
LogP (XLogP3)	-0.8
H-bond donors / acceptors	2 / 3
TPSA	66.4 Å²
Synonyms	(R)-(+)-2-Pyrrolidone-5-carboxylic acid, 5-oxo-D-proline, D-Proline, 5-oxo-, D-Pidolic acid, (+)-Pyroglutamic acid, (+)-Pidolic acid, D-5-Pyrrolidone-2-carboxylic acid, D-5-Oxoproline, (R)-5-Oxopyrrolidine-2-carboxylic Acid, D-Pyr-OH, H-D-Pyr-OH

Safety & hazard information (GHS)

Harmful / irritant

Signal word: Warning

Hazard statements

H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation

Precautionary statements: P261, P264, P264 + P265, P271, P280, P302 + P352, P304 + P340, P305 + P351 + P338, P319, P321, P332 + P317, P337 + P317, P362 + P364, P403 + P233, P405, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of D-Pyroglutamic Acid?

The CAS Registry Number of D-Pyroglutamic Acid is 4042-36-8. It is also known as (R)-(+)-2-Pyrrolidone-5-carboxylic acid, 5-oxo-D-proline, D-Proline, 5-oxo-.

What is the molecular formula and molecular weight of D-Pyroglutamic Acid?

D-Pyroglutamic Acid has the molecular formula C5H7NO3 and a molecular weight of 129.11 g/mol. Its IUPAC name is (2R)-5-oxopyrrolidine-2-carboxylic acid.

What is D-Pyroglutamic Acid used for?

D-Pyroglutamic Acid is supplied as a characterised reference material related to Allopurinol. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of D-Pyroglutamic Acid can I order?

We supply D-Pyroglutamic Acid in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with D-Pyroglutamic Acid?

Yes. Every lot of D-Pyroglutamic Acid is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can D-Pyroglutamic Acid be shipped internationally?

Yes. D-Pyroglutamic Acid is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.