(R)-Cetirizine N-Oxide

About (R)-Cetirizine N-Oxide

(R)-Cetirizine N-Oxide is a metabolite or degradation product of Cetirizine carrying the CAS registry number 442863-80-1. Its molecular formula is C21H25ClN2O4 and its molecular weight is 404.9 g/mol. Its systematic (IUPAC) name is 2-[2-[4-[(R)-(4-chlorophenyl)-phenylmethyl]-1-oxidopiperazin-1-ium-1-yl]ethoxy]acetic acid. It is also known as Levocetirizine N-Oxide or (R)-Cetirizine N-Oxide DiHCl.

It is supplied as a solid. Reference materials should be stored sealed and away from light and moisture, as specified on the accompanying COA. The GHS classification uses the signal word “Warning”, so appropriate gloves, eye protection and ventilation are recommended.

It is used in metabolite identification, stability-indicating method development and impurity profiling of Cetirizine, as well as in QC testing and ANDA/DMF documentation. Buyers come mainly from pharmaceutical manufacturing and academic and industrial research.

Standard pack sizes are 10 mg, 25 mg, 50 mg and 100 mg, and every batch ships with a Certificate of Analysis (COA) and we export worldwide.

Typical applications

Metabolite identification
Stability-indicating methods
Impurity profiling

Industries

Related to Cetirizine

View every impurity, metabolite and intermediate we list for Cetirizine.

Cetirizine impurities

Specifications & identifiers

Chemical identifiers
Product name	(R)-Cetirizine N-Oxide
Catalogue No.	VQ-007082
CAS Number	442863-80-1
IUPAC name	2-[2-[4-[(R)-(4-chlorophenyl)-phenylmethyl]-1-oxidopiperazin-1-ium-1-yl]ethoxy]acetic acid
Molecular formula	C₂₁H₂₅ClN₂O₄
Molecular weight	404.9 g/mol
Exact mass	404.1503
Grade	Reference Standard
HSN code	38229090
InChIKey	IVDOUUOLLFEMJQ-OAQYLSRUSA-N
SMILES	C1C[N+](CCN1[C@H](C2=CC=CC=C2)C3=CC=C(C=C3)Cl)(CCOCC(=O)O)[O-]
PubChem CID	29975673

Physical properties
Physical form	Solid
LogP (XLogP3)	1.1
H-bond donors / acceptors	1 / 5
TPSA	67.8 Å²
Synonyms	Levocetirizine N-Oxide, (R)-1-(2-(carboxymethoxy)ethyl)-4-((4-chlorophenyl)(phenyl)methyl)piperazine 1-oxide, (R)-[2-[4-(4-Chlorophenyl)phenylmethyl]-1-oxido-1-piperazinyl]ethoxy]acetic Acid, Acetic acid, 2-(2-(4-((R)-(4-chlorophenyl)phenylmethyl)-1-oxido-1-piperazinyl)ethoxy)-, Acetic acid, 2-[2-[4-[(R)-(4-chlorophenyl)phenylmethyl]-1-oxido-1-piperazinyl]ethoxy]-, (R)-Cetirizine N-Oxide DiHCl

Safety & hazard information (GHS)

Harmful / irritant

Signal word: Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements: P264, P270, P301 + P317, P330, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of (R)-Cetirizine N-Oxide?

The CAS Registry Number of (R)-Cetirizine N-Oxide is 442863-80-1. It is also known as Levocetirizine N-Oxide, (R)-1-(2-(carboxymethoxy)ethyl)-4-((4-chlorophenyl)(phenyl)methyl)piperazine 1-oxide, (R)-[2-[4-(4-Chlorophenyl)phenylmethyl]-1-oxido-1-piperazinyl]ethoxy]acetic Acid.

What is the molecular formula and molecular weight of (R)-Cetirizine N-Oxide?

(R)-Cetirizine N-Oxide has the molecular formula C21H25ClN2O4 and a molecular weight of 404.9 g/mol. Its IUPAC name is 2-[2-[4-[(R)-(4-chlorophenyl)-phenylmethyl]-1-oxidopiperazin-1-ium-1-yl]ethoxy]acetic acid.

What is (R)-Cetirizine N-Oxide used for?

(R)-Cetirizine N-Oxide is supplied as a characterised reference material related to Cetirizine. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of (R)-Cetirizine N-Oxide can I order?

We supply (R)-Cetirizine N-Oxide in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with (R)-Cetirizine N-Oxide?

Yes. Every lot of (R)-Cetirizine N-Oxide is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can (R)-Cetirizine N-Oxide be shipped internationally?

Yes. (R)-Cetirizine N-Oxide is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.