2-(Thiophen-2-ylmethyl)malonic Acid

About 2-(Thiophen-2-ylmethyl)malonic Acid

2-(Thiophen-2-ylmethyl)malonic Acid is an impurity of Eprosartan carrying the CAS registry number 4475-24-5. With the molecular formula C8H8O4S, it has a molar mass of 200.21 g/mol. Its systematic (IUPAC) name is 2-(thiophen-2-ylmethyl)propanedioic acid. It is also known as 2-[(thiophen-2-yl)methyl]propanedioic acid or 2-(2-thienylmethyl)malonic acid.

It is supplied as a solid. Keep the vial tightly closed, protected from light and humidity, at the temperature stated on the Certificate of Analysis. The GHS classification uses the signal word “Warning”, so appropriate gloves, eye protection and ventilation are recommended.

As a characterised impurity of Eprosartan, it is used for analytical method development, method validation (AMV) and routine quality-control testing, and it supports ANDA and DMF regulatory filings. Our customers for this product work in pharmaceutical manufacturing and academic and industrial research.

We offer 2-(Thiophen-2-ylmethyl)malonic Acid in 10 mg, 25 mg, 50 mg and 100 mg packs with a batch-specific COA, and ship to customers worldwide.

Typical applications

Analytical method development
Method validation (AMV)
QC release testing
ANDA / DMF filings

Industries

Related to Eprosartan

View every impurity, metabolite and intermediate we list for Eprosartan.

Eprosartan impurities

Specifications & identifiers

Chemical identifiers
Product name	2-(Thiophen-2-ylmethyl)malonic Acid
Catalogue No.	VQ-043156
CAS Number	4475-24-5
IUPAC name	2-(thiophen-2-ylmethyl)propanedioic acid
Molecular formula	C₈H₈O₄S
Molecular weight	200.21 g/mol
Exact mass	200.0143
Grade	Reference Standard
HSN code	38229090
InChIKey	PGGOEUVKDHKGKQ-UHFFFAOYSA-N
SMILES	C1=CSC(=C1)CC(C(=O)O)C(=O)O
PubChem CID	236591

Physical properties
Physical form	Solid
LogP (XLogP3)	1.2
H-bond donors / acceptors	2 / 5
TPSA	103 Å²

Safety & hazard information (GHS)

Harmful / irritant

Signal word: Warning

Hazard statements

H302Harmful if swallowed
H312Harmful in contact with skin
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation

Precautionary statements: P261, P264, P264 + P265, P270, P271, P280, P301 + P317, P302 + P352, P304 + P340, P305 + P351 + P338, P317, P319, P321, P330, P332 + P317, P337 + P317, P362 + P364, P403 + P233, P405, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of 2-(Thiophen-2-ylmethyl)malonic Acid?

The CAS Registry Number of 2-(Thiophen-2-ylmethyl)malonic Acid is 4475-24-5. It is also known as 2-[(thiophen-2-yl)methyl]propanedioic acid, 2-(2-thienylmethyl)malonic acid, 2-(thiophen-2-ylmethyl)propanedioicacid.

What is the molecular formula and molecular weight of 2-(Thiophen-2-ylmethyl)malonic Acid?

2-(Thiophen-2-ylmethyl)malonic Acid has the molecular formula C8H8O4S and a molecular weight of 200.21 g/mol. Its IUPAC name is 2-(thiophen-2-ylmethyl)propanedioic acid.

What is 2-(Thiophen-2-ylmethyl)malonic Acid used for?

2-(Thiophen-2-ylmethyl)malonic Acid is supplied as a characterised reference material related to Eprosartan. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of 2-(Thiophen-2-ylmethyl)malonic Acid can I order?

We supply 2-(Thiophen-2-ylmethyl)malonic Acid in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with 2-(Thiophen-2-ylmethyl)malonic Acid?

Yes. Every lot of 2-(Thiophen-2-ylmethyl)malonic Acid is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can 2-(Thiophen-2-ylmethyl)malonic Acid be shipped internationally?

Yes. 2-(Thiophen-2-ylmethyl)malonic Acid is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.