Oripavine

Name: Oripavine
Brand: Vaqora Chemicals
SKU: VQ-051738

About Oripavine

Listed under CAS 467-04-9, Oripavine is a process intermediate or related compound of Codeine available from Vaqora Chemicals. Formula C18H19NO3, molecular weight 297.3 g/mol. The IUPAC name is (4R,7aR,12bS)-7-methoxy-3-methyl-2,4,7a,13-tetrahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-9-ol. Alternative names: IDS-NO-010 and O(3)-Dimethylthebaine.

It is supplied as a solid. Keep the vial tightly closed, protected from light and humidity, at the temperature stated on the Certificate of Analysis. Under GHS it is labelled “Danger”, so handle it with suitable PPE and consult the SDS.

It is a process intermediate or related compound in the synthesis of Codeine, useful for route development, impurity fate-and-purge studies and analytical method development. Buyers come mainly from pharmaceutical manufacturing and academic and industrial research.

Available in 10 mg, 25 mg, 50 mg and 100 mg packs, Oripavine is dispatched with a Certificate of Analysis (COA) to destinations worldwide.

Typical applications

API route development
Impurity fate & purge studies
Analytical method development
Fine chemical synthesis

Industries

Related to Codeine

View every impurity, metabolite and intermediate we list for Codeine.

Codeine impurities

Specifications & identifiers

Chemical identifiers
Product name	Oripavine
Catalogue No.	VQ-051738
CAS Number	467-04-9
IUPAC name	(4R,7aR,12bS)-7-methoxy-3-methyl-2,4,7a,13-tetrahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-9-ol
Molecular formula	C₁₈H₁₉NO₃
Molecular weight	297.3 g/mol
Exact mass	297.1365
HSN code	2933
InChIKey	ZKLXUUYLEHCAMF-UUWFMWQGSA-N
SMILES	CN1CC[C@]23[C@@H]4C(=CC=C2[C@H]1CC5=C3C(=C(C=C5)O)O4)OC
PubChem CID	5462306

Physical properties
Physical form	Solid
LogP (XLogP3)	1.9
H-bond donors / acceptors	1 / 4
TPSA	41.9 Å²
Synonyms	IDS-NO-010, 6,7,8,14-Tetradehydro-4,5-alpha-epoxy-6-methoxy-17-methyl-morphinan-3-ol, O(3)-Dimethylthebaine, 6-demethoxythebaine, 3-O-Demethylthebaine, 6,7,8,14-Tetradehydro-4,5alpha-epoxy-6-methoxy-17-methylmorphinan-3-ol (Oripavine), (5alpha)-6,7,8,14-Tetradehydro-4,5-epoxy-6-methoxy-17-methylmorphinan-3-ol, Morphinan-3-ol, 6,7,8,14-tetradehydro-4,5-epoxy-6-methoxy-17-methyl-, (5.alpha.)-, Morphinan-3-ol, 6,7,8,14-tetradehydro-4,5-alpha-epoxy-6-methoxy-17-methyl-, 6-Methoxy-17-methyl-5alpha-6,7,8,14-tetradehydro-4,5-epoxymorphinan-3-ol

Safety & hazard information (GHS)

Toxic

Harmful / irritant

Health hazard

Signal word: Danger

Hazard statements

H301Toxic if swallowed
H302Harmful if swallowed
H311Toxic in contact with skin
H317May cause an allergic skin reaction
H331Toxic if inhaled
H334May cause allergy or asthma symptoms or breathing difficulties if inhaled
H361Suspected of damaging fertility or the unborn child

Precautionary statements: P203, P233, P260, P261, P262, P264, P270, P271, P272, P280, P284, P301 + P316, P301 + P317, P302 + P352, P304 + P340, P316, P318, P321, P330, P333 + P317, P342 + P316, P361 + P364, P362 + P364, P403

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of Oripavine?

The CAS Registry Number of Oripavine is 467-04-9. It is also known as IDS-NO-010, 6,7,8,14-Tetradehydro-4,5-alpha-epoxy-6-methoxy-17-methyl-morphinan-3-ol, O(3)-Dimethylthebaine.

What is the molecular formula and molecular weight of Oripavine?

Oripavine has the molecular formula C18H19NO3 and a molecular weight of 297.3 g/mol. Its IUPAC name is (4R,7aR,12bS)-7-methoxy-3-methyl-2,4,7a,13-tetrahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-9-ol.

What is Oripavine used for?

Oripavine is supplied as a characterised reference material related to Codeine. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of Oripavine can I order?

We supply Oripavine, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with Oripavine?

Yes. Every lot of Oripavine is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can Oripavine be shipped internationally?

Yes. Oripavine is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.