Boldine

About Boldine

Boldine is a high-purity reference standard of Boldine carrying the CAS registry number 476-70-0. Formula C19H21NO4, molecular weight 327.4 g/mol. Its systematic (IUPAC) name is (6aS)-1,10-dimethoxy-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline-2,9-diol. Common synonyms include (S)-Boldine and 1,10-Dimethoxy-2,9-dihydroxyaporphine.

It is supplied as a solid. Store the standard in its sealed vial, protected from light and moisture, and follow the storage condition printed on the COA. The GHS classification uses the signal word “Warning”, so appropriate gloves, eye protection and ventilation are recommended.

Laboratories use this Boldine standard for identity and assay testing, system suitability checks and method validation supporting ANDA and DMF filings. Typical end-use sectors are pharmaceutical manufacturing and academic and industrial research.

Standard pack sizes are 10 mg, 25 mg, 50 mg and 100 mg, and every batch ships with a Certificate of Analysis (COA) and we export worldwide.

Typical applications

Identification & assay
Method development & validation
QC reference material

Industries

Related to Boldine

View every impurity, metabolite and intermediate we list for Boldine.

Boldine impurities

Specifications & identifiers

Chemical identifiers
Product name	Boldine
Catalogue No.	VQ-029469
CAS Number	476-70-0
IUPAC name	(6aS)-1,10-dimethoxy-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline-2,9-diol
Molecular formula	C₁₉H₂₁NO₄
Molecular weight	327.4 g/mol
Exact mass	327.1471
Grade	Reference Standard
HSN code	38229090
InChIKey	LZJRNLRASBVRRX-ZDUSSCGKSA-N
SMILES	CN1CCC2=CC(=C(C3=C2[C@@H]1CC4=CC(=C(C=C43)OC)O)OC)O
PubChem CID	10154

Physical properties
Physical form	Solid
LogP (XLogP3)	2.7
H-bond donors / acceptors	2 / 5
TPSA	62.2 Å²
Synonyms	(S)-Boldine, 1,10-Dimethoxy-2,9-dihydroxyaporphine, 4H-Dibenzo(de,g)quinoline-2,9-diol, 5,6,6a,7-tetrahydro-1,10-dimethoxy-6-methyl-, (6aS)-, 4H-Dibenzo[de,g]quinoline-2,9-diol, 5,6,6a,7-tetrahydro-1,10-dimethoxy-6-methyl-, (6aS)-, Boldin, Boldine chloroform, (S)-1,10-dimethoxy-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline-2,9-diol, 4H-Dibenzo(de,g)quinoline-2,9-diol, 5,6,6a,7-tetrahydro-1,10-dimethoxy-6-methyl-, (S)-, (+)-(S)-Boldine, ex Peumus boldus, 1,10-Dimethoxy-6a-alpha-aporphine-2,9-diol

Safety & hazard information (GHS)

Harmful / irritant

Signal word: Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements: P264, P270, P301 + P317, P330, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of Boldine?

The CAS Registry Number of Boldine is 476-70-0. It is also known as (S)-Boldine, 1,10-Dimethoxy-2,9-dihydroxyaporphine, 4H-Dibenzo(de,g)quinoline-2,9-diol, 5,6,6a,7-tetrahydro-1,10-dimethoxy-6-methyl-, (6aS)-.

What is the molecular formula and molecular weight of Boldine?

Boldine has the molecular formula C19H21NO4 and a molecular weight of 327.4 g/mol. Its IUPAC name is (6aS)-1,10-dimethoxy-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline-2,9-diol.

What is Boldine used for?

Boldine is supplied as a characterised reference material related to Boldine. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of Boldine can I order?

We supply Boldine in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with Boldine?

Yes. Every lot of Boldine is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can Boldine be shipped internationally?

Yes. Boldine is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.