Desmethyl Thiosildenafil

About Desmethyl Thiosildenafil

Desmethyl Thiosildenafil is a metabolite or degradation product of Sildenafil carrying the CAS registry number 479073-86-4. Its molecular formula is C21H28N6O3S2 and its molecular weight is 476.6 g/mol. Its systematic (IUPAC) name is 5-(2-ethoxy-5-piperazin-1-ylsulfonylphenyl)-1-methyl-3-propyl-4H-pyrazolo[4,5-d]pyrimidine-7-thione. Alternative names: N-Desmethylthiosildenafil.

The product is provided as a solid. Keep the vial tightly closed, protected from light and humidity, at the temperature stated on the Certificate of Analysis. Handle it with standard laboratory precautions and appropriate personal protective equipment.

It is used in metabolite identification, stability-indicating method development and impurity profiling of Sildenafil, as well as in QC testing and ANDA/DMF documentation. Typical end-use sectors are pharmaceutical manufacturing and academic and industrial research.

Available in 10 mg, 25 mg, 50 mg and 100 mg packs, Desmethyl Thiosildenafil is dispatched with a Certificate of Analysis (COA) to destinations worldwide.

Typical applications

Metabolite identification
Stability-indicating methods
Impurity profiling

Industries

Related to Sildenafil

View every impurity, metabolite and intermediate we list for Sildenafil.

Sildenafil impurities

Specifications & identifiers

Chemical identifiers
Product name	Desmethyl Thiosildenafil
Catalogue No.	VQ-044132
CAS Number	479073-86-4
IUPAC name	5-(2-ethoxy-5-piperazin-1-ylsulfonylphenyl)-1-methyl-3-propyl-4H-pyrazolo[4,5-d]pyrimidine-7-thione
Molecular formula	C₂₁H₂₈N₆O₃S₂
Molecular weight	476.6 g/mol
Exact mass	476.1664
Grade	Reference Standard
HSN code	38229090
InChIKey	VMDTWBKYCKLNLA-UHFFFAOYSA-N
SMILES	CCCC1=NN(C2=C1NC(=NC2=S)C3=C(C=CC(=C3)S(=O)(=O)N4CCNCC4)OCC)C
PubChem CID	10140449

Physical properties
Physical form	Solid
LogP (XLogP3)	1.6
H-bond donors / acceptors	2 / 7
TPSA	141 Å²

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of Desmethyl Thiosildenafil?

The CAS Registry Number of Desmethyl Thiosildenafil is 479073-86-4. It is also known as N-Desmethylthiosildenafil.

What is the molecular formula and molecular weight of Desmethyl Thiosildenafil?

Desmethyl Thiosildenafil has the molecular formula C21H28N6O3S2 and a molecular weight of 476.6 g/mol. Its IUPAC name is 5-(2-ethoxy-5-piperazin-1-ylsulfonylphenyl)-1-methyl-3-propyl-4H-pyrazolo[4,5-d]pyrimidine-7-thione.

What is Desmethyl Thiosildenafil used for?

Desmethyl Thiosildenafil is supplied as a characterised reference material related to Sildenafil. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of Desmethyl Thiosildenafil can I order?

We supply Desmethyl Thiosildenafil in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with Desmethyl Thiosildenafil?

Yes. Every lot of Desmethyl Thiosildenafil is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can Desmethyl Thiosildenafil be shipped internationally?

Yes. We export Desmethyl Thiosildenafil worldwide by air and sea freight or express courier, on EXW, FOB, CIF, CFR or DAP Incoterms, with full export documentation.