Nitrilotriacetamide

About Nitrilotriacetamide

Nitrilotriacetamide is an impurity of Allopurinol carrying the CAS registry number 4862-18-4. The compound has the formula C6H12N4O3, corresponding to a molecular weight of 188.18 g/mol. Systematically, it is named 2-[bis(2-amino-2-oxoethyl)amino]acetamide. Alternative names: 2,2',2''-Nitrilotris(acetamide) and Acetamide, 2,2',2''-nitrilotris-.

It is supplied as a solid. Keep the vial tightly closed, protected from light and humidity, at the temperature stated on the Certificate of Analysis. It carries the GHS signal word “Warning” with 2 hazard statements. Review the Safety Data Sheet before use.

Pharmaceutical QC and development laboratories use this impurity standard of Allopurinol to develop and validate HPLC methods, to set specification limits and to document impurity profiles in ANDA and DMF submissions. Typical end-use sectors are pharmaceutical manufacturing and academic and industrial research.

Available in 10 mg, 25 mg, 50 mg and 100 mg packs, Nitrilotriacetamide is dispatched with a Certificate of Analysis (COA) to destinations worldwide.

Typical applications

Analytical method development
Method validation (AMV)
QC release testing
ANDA / DMF filings

Industries

Related to Allopurinol

View every impurity, metabolite and intermediate we list for Allopurinol.

Allopurinol impurities

Specifications & identifiers

Chemical identifiers
Product name	Nitrilotriacetamide
Catalogue No.	VQ-047365
CAS Number	4862-18-4
IUPAC name	2-[bis(2-amino-2-oxoethyl)amino]acetamide
Molecular formula	C₆H₁₂N₄O₃
Molecular weight	188.18 g/mol
Exact mass	188.0909
Grade	Reference Standard
HSN code	38229090
InChIKey	CVTGEDNIBVTKBJ-UHFFFAOYSA-N
SMILES	C(C(=O)N)N(CC(=O)N)CC(=O)N
PubChem CID	78580

Physical properties
Physical form	Solid
LogP (XLogP3)	-2.9
H-bond donors / acceptors	3 / 4
TPSA	133 Å²
Synonyms	2,2',2''-Nitrilotris(acetamide), Acetamide, 2,2',2''-nitrilotris-, 2,2',2''-Nitrilotris[acetamide], ntam cpd, Nitrilotris(acetamide), 2,2',2''-nitrilotriacetamide, Nitrilotris[acetamide], 2,2',2''-Nitrilotrisacetamide, 2,2''-Nitrilotrisacetamide, 2,2',2"-Nitrilotriacetamide, Acetamide,2',2''-nitrilotris-

Safety & hazard information (GHS)

Harmful / irritant

Signal word: Warning

Hazard statements

H315Causes skin irritation
H319Causes serious eye irritation

Precautionary statements: P264, P264 + P265, P280, P302 + P352, P305 + P351 + P338, P321, P332 + P317, P337 + P317, P362 + P364

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of Nitrilotriacetamide?

The CAS Registry Number of Nitrilotriacetamide is 4862-18-4. It is also known as 2,2',2''-Nitrilotris(acetamide), Acetamide, 2,2',2''-nitrilotris-, 2,2',2''-Nitrilotris[acetamide].

What is the molecular formula and molecular weight of Nitrilotriacetamide?

Nitrilotriacetamide has the molecular formula C6H12N4O3 and a molecular weight of 188.18 g/mol. Its IUPAC name is 2-[bis(2-amino-2-oxoethyl)amino]acetamide.

What is Nitrilotriacetamide used for?

Nitrilotriacetamide is supplied as a characterised reference material related to Allopurinol. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of Nitrilotriacetamide can I order?

We supply Nitrilotriacetamide in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with Nitrilotriacetamide?

Yes. Every lot of Nitrilotriacetamide is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can Nitrilotriacetamide be shipped internationally?

Yes. Nitrilotriacetamide is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.