Methyl (S)-Pyroglutamate

About Methyl (S)-Pyroglutamate

Methyl (S)-Pyroglutamate is an API impurity reference standard carrying the CAS registry number 4931-66-2. Its molecular formula is C6H9NO3 and its molecular weight is 143.14 g/mol. Systematically, it is named methyl (2S)-5-oxopyrrolidine-2-carboxylate. It is also known as Methyl L-pyroglutamate or Methyl 5-oxo-L-prolinate.

It is supplied as a solid. Store the standard in its sealed vial, protected from light and moisture, and follow the storage condition printed on the COA. The GHS classification uses the signal word “Warning”, so appropriate gloves, eye protection and ventilation are recommended.

This the parent drug substance impurity supports analytical method development and validation (AMV), batch release testing and the impurity sections of ANDA and DMF filings. Typical end-use sectors are pharmaceutical manufacturing and academic and industrial research.

Available in 10 mg, 25 mg, 50 mg and 100 mg packs, Methyl (S)-Pyroglutamate is dispatched with a Certificate of Analysis (COA) to destinations worldwide.

Typical applications

Analytical method development
Method validation (AMV)
QC release testing
ANDA / DMF filings

Industries

Specifications & identifiers

Chemical identifiers
Product name	Methyl (S)-Pyroglutamate
Catalogue No.	VQ-032922
CAS Number	4931-66-2
IUPAC name	methyl (2S)-5-oxopyrrolidine-2-carboxylate
Molecular formula	C₆H₉NO₃
Molecular weight	143.14 g/mol
Exact mass	143.0582
Grade	Reference Standard
HSN code	38229090
InChIKey	HQGPKMSGXAUKHT-BYPYZUCNSA-N
SMILES	COC(=O)[C@@H]1CCC(=O)N1
PubChem CID	78646

Physical properties
Physical form	Solid
LogP (XLogP3)	-0.4
H-bond donors / acceptors	1 / 3
TPSA	55.4 Å²
Synonyms	Methyl L-pyroglutamate, Methyl 5-oxo-L-prolinate, Methyl pyroglutamate, Methyl (S)-(+)-2-pyrrolidone-5-carboxylate, (S)-Methyl 5-oxopyrrolidine-2-carboxylate, H-Pyr-OMe, Methyl (S)-5-Oxopyrrolidine-2-carboxylate, L-Proline, 5-oxo-, methyl ester, (S)-Pyroglutamic Acid Methyl Ester, Methyl ester of L-Pyrrolidonecarboxylic acid, methyl(s)-(+)-2 pyrrolidone-5-carboxylate, methyl(S)-(+)-2-pyrrolidone-5-carboxylate

Safety & hazard information (GHS)

Harmful / irritant

Signal word: Warning

Hazard statements

H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation

Precautionary statements: P261, P264, P264 + P265, P271, P280, P302 + P352, P304 + P340, P305 + P351 + P338, P319, P321, P332 + P317, P337 + P317, P362 + P364, P403 + P233, P405, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of Methyl (S)-Pyroglutamate?

The CAS Registry Number of Methyl (S)-Pyroglutamate is 4931-66-2. It is also known as Methyl L-pyroglutamate, Methyl 5-oxo-L-prolinate, Methyl pyroglutamate.

What is the molecular formula and molecular weight of Methyl (S)-Pyroglutamate?

Methyl (S)-Pyroglutamate has the molecular formula C6H9NO3 and a molecular weight of 143.14 g/mol. Its IUPAC name is methyl (2S)-5-oxopyrrolidine-2-carboxylate.

Which grade and pack sizes of Methyl (S)-Pyroglutamate can I order?

We supply Methyl (S)-Pyroglutamate in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with Methyl (S)-Pyroglutamate?

Yes. Every lot of Methyl (S)-Pyroglutamate is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can Methyl (S)-Pyroglutamate be shipped internationally?

Yes. Methyl (S)-Pyroglutamate is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.