Givinostat

Name: Givinostat
Brand: Vaqora Chemicals
SKU: VQ-025990

About Givinostat

Vaqora Chemicals supplies Givinostat, a high-purity reference standard of Givinostat registered under CAS number 497833-27-9. With the molecular formula C24H27N3O4, it has a molar mass of 421.5 g/mol. Systematically, it is named [6-(diethylaminomethyl)naphthalen-2-yl]methyl N-[4-(hydroxycarbamoyl)phenyl]carbamate. Common synonyms include ITF-2357 and Givinostat free base.

It is supplied as a solid. Keep the vial tightly closed, protected from light and humidity, at the temperature stated on the Certificate of Analysis. It carries the GHS signal word “Warning” with 4 hazard statements. Review the Safety Data Sheet before use.

Laboratories use this Givinostat standard for identity and assay testing, system suitability checks and method validation supporting ANDA and DMF filings. Buyers come mainly from pharmaceutical manufacturing and academic and industrial research.

Vaqora Chemicals supplies Givinostat in 10 mg, 25 mg, 50 mg and 100 mg packs, each shipped with a Certificate of Analysis (COA), and exports worldwide.

Typical applications

Identification & assay
Method development & validation
QC reference material

Industries

Related to Givinostat

View every impurity, metabolite and intermediate we list for Givinostat.

Givinostat impurities

Specifications & identifiers

Chemical identifiers
Product name	Givinostat
Catalogue No.	VQ-025990
CAS Number	497833-27-9
IUPAC name	[6-(diethylaminomethyl)naphthalen-2-yl]methyl N-[4-(hydroxycarbamoyl)phenyl]carbamate
Molecular formula	C₂₄H₂₇N₃O₄
Molecular weight	421.5 g/mol
Exact mass	421.2002
Grade	Reference Standard
HSN code	38229090
InChIKey	YALNUENQHAQXEA-UHFFFAOYSA-N
SMILES	CCN(CC)CC1=CC2=C(C=C1)C=C(C=C2)COC(=O)NC3=CC=C(C=C3)C(=O)NO
PubChem CID	9804992

Physical properties
Physical form	Solid
LogP (XLogP3)	3.6
H-bond donors / acceptors	3 / 5
TPSA	90.9 Å²
Synonyms	ITF-2357, (6-(diethylaminomethyl)naphthalen-2-yl)methyl N-(4-(hydroxycarbamoyl)phenyl)carbamate, (6-((diethylamino)methyl)naphthalen-2-yl)methyl (4-(hydroxycarbamoyl)phenyl)carbamate, Givinostat free base, {6-[(diethylamino)methyl]naphthalen-2-yl}methyl [4-(hydroxycarbamoyl)phenyl]carbamate, (6-((Diethylamino)methyl)naphthalen-2-yl)methyl(4-(hydroxycarbamoyl)phenyl)carbamate, [6-(diethylaminomethyl)-2-naphthyl]methyl N-[4-(hydroxycarbamoyl)phenyl]carbamate

Safety & hazard information (GHS)

Harmful / irritant

Signal word: Warning

Hazard statements

H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation

Precautionary statements: P261, P264, P264 + P265, P270, P271, P280, P301 + P317, P302 + P352, P304 + P340, P305 + P351 + P338, P319, P321, P330, P332 + P317, P337 + P317, P362 + P364, P403 + P233, P405, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of Givinostat?

The CAS Registry Number of Givinostat is 497833-27-9. It is also known as ITF-2357, (6-(diethylaminomethyl)naphthalen-2-yl)methyl N-(4-(hydroxycarbamoyl)phenyl)carbamate, (6-((diethylamino)methyl)naphthalen-2-yl)methyl (4-(hydroxycarbamoyl)phenyl)carbamate.

What is the molecular formula and molecular weight of Givinostat?

Givinostat has the molecular formula C24H27N3O4 and a molecular weight of 421.5 g/mol. Its IUPAC name is [6-(diethylaminomethyl)naphthalen-2-yl]methyl N-[4-(hydroxycarbamoyl)phenyl]carbamate.

What is Givinostat used for?

Givinostat is supplied as a characterised reference material related to Givinostat. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of Givinostat can I order?

We supply Givinostat in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with Givinostat?

Yes. Every lot of Givinostat is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can Givinostat be shipped internationally?

Yes. Givinostat is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.