(-)-Dihydroquinine

Name: (-)-Dihydroquinine
Brand: Vaqora Chemicals
SKU: VQ-027705

About (-)-Dihydroquinine

Listed under CAS 522-66-7, (-)-Dihydroquinine is an impurity of Quinine available from Vaqora Chemicals. The compound has the formula C20H26N2O2, corresponding to a molecular weight of 326.4 g/mol. Systematically, it is named (R)-[(2S,4S,5R)-5-ethyl-1-azabicyclo[2.2.2]octan-2-yl]-(6-methoxyquinolin-4-yl)methanol. It is also known as 10,11-dihydroquinine or (-)-hydroquinine.

The product is provided as a solid. Keep the vial tightly closed, protected from light and humidity, at the temperature stated on the Certificate of Analysis. Under GHS it is labelled “Warning”, so handle it with suitable PPE and consult the SDS.

This Quinine impurity supports analytical method development and validation (AMV), batch release testing and the impurity sections of ANDA and DMF filings. Buyers come mainly from pharmaceutical manufacturing and academic and industrial research.

We offer (-)-Dihydroquinine in 10 mg, 25 mg, 50 mg and 100 mg packs with a batch-specific COA, and ship to customers worldwide.

Typical applications

Analytical method development
Method validation (AMV)
QC release testing
ANDA / DMF filings

Industries

Related to Quinine

View every impurity, metabolite and intermediate we list for Quinine.

Quinine impurities

Specifications & identifiers

Chemical identifiers
Product name	(-)-Dihydroquinine
Catalogue No.	VQ-027705
CAS Number	522-66-7
IUPAC name	(R)-[(2S,4S,5R)-5-ethyl-1-azabicyclo[2.2.2]octan-2-yl]-(6-methoxyquinolin-4-yl)methanol
Molecular formula	C₂₀H₂₆N₂O₂
Molecular weight	326.4 g/mol
Exact mass	326.1994
Grade	Reference Standard
HSN code	38229090
InChIKey	LJOQGZACKSYWCH-WZBLMQSHSA-N
SMILES	CC[C@H]1CN2CC[C@H]1C[C@H]2[C@@H](C3=C4C=C(C=CC4=NC=C3)OC)O
PubChem CID	121515

Physical properties
Physical form	Solid
LogP (XLogP3)	3.1
H-bond donors / acceptors	1 / 4
TPSA	45.6 Å²
Synonyms	10,11-dihydroquinine, (-)-hydroquinine, (-)-10,11-dihydroquinine, Cinchonan-9-ol, 10,11-dihydro-6'-methoxy-, (8alpha,9R)-, (R)-((1S,2S,4S,5R)-5-ethyl-1-azabicyclo(2.2.2)octan-2-yl)(6-methoxyquinolin-4-yl)methanol, (1R)-((2S,4S,5R)-5-Ethylquinuclidin-2-yl)(6-methoxyquinolin-4-yl)methanol, (R)-((1S,2S,4S,5R)-5-ethylquinuclidin-2-yl)(6-methoxyquinolin-4-yl)methanol, (R)-[(2S,4S,5R)-5-ethylquinuclidin-2-yl]-(6-methoxy-4-quinolyl)methanol, (8alpha,9R)-10,11-Dihydro-6'-methoxycinchonan-9-ol, Hydrochinin, Quinine, 10,11-dihydro-

Safety & hazard information (GHS)

Harmful / irritant

Signal word: Warning

Hazard statements

H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation

Precautionary statements: P261, P264, P264 + P265, P271, P280, P302 + P352, P304 + P340, P305 + P351 + P338, P319, P321, P332 + P317, P337 + P317, P362 + P364, P403 + P233, P405, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of (-)-Dihydroquinine?

The CAS Registry Number of (-)-Dihydroquinine is 522-66-7. It is also known as 10,11-dihydroquinine, (-)-hydroquinine, (-)-10,11-dihydroquinine.

What is the molecular formula and molecular weight of (-)-Dihydroquinine?

(-)-Dihydroquinine has the molecular formula C20H26N2O2 and a molecular weight of 326.4 g/mol. Its IUPAC name is (R)-[(2S,4S,5R)-5-ethyl-1-azabicyclo[2.2.2]octan-2-yl]-(6-methoxyquinolin-4-yl)methanol.

What is (-)-Dihydroquinine used for?

(-)-Dihydroquinine is supplied as a characterised reference material related to Quinine. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of (-)-Dihydroquinine can I order?

We supply (-)-Dihydroquinine in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with (-)-Dihydroquinine?

Yes. Every lot of (-)-Dihydroquinine is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can (-)-Dihydroquinine be shipped internationally?

Yes. (-)-Dihydroquinine is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.