((+/-)-Corey Lactone Diol

Name: ((+/-)-Corey Lactone Diol
Brand: Vaqora Chemicals
SKU: VQ-048972

About ((+/-)-Corey Lactone Diol

Vaqora Chemicals supplies ((+/-)-Corey Lactone Diol, a metabolite or degradation product of Lubiprostone registered under CAS number 54423-47-1. Its molecular formula is C8H12O4 and its molecular weight is 172.18 g/mol. Its systematic (IUPAC) name is (3aR,4S,5R,6aS)-5-hydroxy-4-(hydroxymethyl)-3,3a,4,5,6,6a-hexahydrocyclopenta[b]furan-2-one. Alternative names: rel-Corey lactone diol.

The product is provided as a solid. Keep the vial tightly closed, protected from light and humidity, at the temperature stated on the Certificate of Analysis. The GHS classification uses the signal word “Danger”, so appropriate gloves, eye protection and ventilation are recommended.

It is used in metabolite identification, stability-indicating method development and impurity profiling of Lubiprostone, as well as in QC testing and ANDA/DMF documentation. It is used across pharmaceutical manufacturing and academic and industrial research.

Vaqora Chemicals supplies ((+/-)-Corey Lactone Diol in 10 mg, 25 mg, 50 mg and 100 mg packs, each shipped with a Certificate of Analysis (COA), and exports worldwide.

Typical applications

Metabolite identification
Stability-indicating methods
Impurity profiling

Industries

Related to Lubiprostone

View every impurity, metabolite and intermediate we list for Lubiprostone.

Lubiprostone impurities

Specifications & identifiers

Chemical identifiers
Product name	((+/-)-Corey Lactone Diol
Catalogue No.	VQ-048972
CAS Number	54423-47-1
IUPAC name	(3aR,4S,5R,6aS)-5-hydroxy-4-(hydroxymethyl)-3,3a,4,5,6,6a-hexahydrocyclopenta[b]furan-2-one
Molecular formula	C₈H₁₂O₄
Molecular weight	172.18 g/mol
Exact mass	172.0736
Grade	Reference Standard
HSN code	38229090
InChIKey	VYTZWRCSPHQSFX-GBNDHIKLSA-N
SMILES	C1[C@H]([C@@H]([C@@H]2[C@H]1OC(=O)C2)CO)O
PubChem CID	2724453

Physical properties
Physical form	Solid
LogP (XLogP3)	-0.2
H-bond donors / acceptors	2 / 4
TPSA	66.8 Å²
Synonyms	(3aR,4S,5R,6aS)-hexahydro-5-hydroxy-4-(hydroxymethyl)-2H-cyclopenta[b]furan-2-one, (3aR,4S,5R,6aS)-(-)-Hexahydro-5-hydroxy-4-(hydroxymethyl)-2H-cyclopenta[b]furan-2-one, (3aR,4S,5R,6aS)-(-)-Hexahydro-5-hydroxy-4-(hydroxymethyl)-2H-cyclopenta(b)furan-2-one, (3aR,4S,5R,6aS)-Hexahydro-5-hydroxy-4-(hydroxymethyl)-2H-cyclopenta(b)furan-2-one, (3aR,4S,5R,6aS)-5-Hydroxy-4-(hydroxymethyl)hexahydro-2H-cyclopenta[b]furan-2-one, rel-Corey lactone diol, rel-(3aR,4S,5R,6aS)-Hexahydro-5-hydroxy-4-(hydroxymethyl)-2H-cyclopenta[b]furan-2-one, (1S,6S,5R,7R)-7-hydroxy-6-(hydroxymethyl)-2-oxabicyclo[3.3.0]octan-3-one, 2H-Cyclopenta[b]furan-2-one, hexahydro-5-hydroxy-4-(hydroxymethyl)-, (3aR,4S,5R,6aS)-

Safety & hazard information (GHS)

Corrosive

Harmful / irritant

Signal word: Danger

Hazard statements

H302Harmful if swallowed
H312Harmful in contact with skin
H318Causes serious eye damage
H332Harmful if inhaled

Precautionary statements: P261, P264, P264 + P265, P270, P271, P280, P301 + P317, P302 + P352, P304 + P340, P305 + P354 + P338, P317, P321, P330, P362 + P364, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of ((+/-)-Corey Lactone Diol?

The CAS Registry Number of ((+/-)-Corey Lactone Diol is 54423-47-1. It is also known as (3aR,4S,5R,6aS)-hexahydro-5-hydroxy-4-(hydroxymethyl)-2H-cyclopenta[b]furan-2-one, (3aR,4S,5R,6aS)-(-)-Hexahydro-5-hydroxy-4-(hydroxymethyl)-2H-cyclopenta[b]furan-2-one, (3aR,4S,5R,6aS)-(-)-Hexahydro-5-hydroxy-4-(hydroxymethyl)-2H-cyclopenta(b)furan-2-one.

What is the molecular formula and molecular weight of ((+/-)-Corey Lactone Diol?

((+/-)-Corey Lactone Diol has the molecular formula C8H12O4 and a molecular weight of 172.18 g/mol. Its IUPAC name is (3aR,4S,5R,6aS)-5-hydroxy-4-(hydroxymethyl)-3,3a,4,5,6,6a-hexahydrocyclopenta[b]furan-2-one.

What is ((+/-)-Corey Lactone Diol used for?

((+/-)-Corey Lactone Diol is supplied as a characterised reference material related to Lubiprostone. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of ((+/-)-Corey Lactone Diol can I order?

We supply ((+/-)-Corey Lactone Diol in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with ((+/-)-Corey Lactone Diol?

Yes. Every lot of ((+/-)-Corey Lactone Diol is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can ((+/-)-Corey Lactone Diol be shipped internationally?

Yes. ((+/-)-Corey Lactone Diol is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.