1-(4-Hydroxyphenyl)piperazine

About 1-(4-Hydroxyphenyl)piperazine

1-(4-Hydroxyphenyl)piperazine is a metabolite or degradation product of Posaconazole carrying the CAS registry number 56621-48-8. With the molecular formula C10H14N2O, it has a molar mass of 178.23 g/mol. Systematically, it is named 4-piperazin-1-ylphenol. It is also known as p-(1-Piperazinyl)phenol or 4-(piperazin-1-yl)phenol.

It is supplied as a solid. Reference materials should be stored sealed and away from light and moisture, as specified on the accompanying COA. Under GHS it is labelled “Danger”, so handle it with suitable PPE and consult the SDS.

It is used in metabolite identification, stability-indicating method development and impurity profiling of Posaconazole, as well as in QC testing and ANDA/DMF documentation. It is used across pharmaceutical manufacturing and academic and industrial research.

Standard pack sizes are 10 mg, 25 mg, 50 mg and 100 mg, and every batch ships with a Certificate of Analysis (COA) and we export worldwide.

Typical applications

Metabolite identification
Stability-indicating methods
Impurity profiling
Fine chemical synthesis

Industries

Related to Posaconazole

View every impurity, metabolite and intermediate we list for Posaconazole.

Posaconazole impurities

Specifications & identifiers

Chemical identifiers
Product name	1-(4-Hydroxyphenyl)piperazine
Catalogue No.	VQ-039514
CAS Number	56621-48-8
IUPAC name	4-piperazin-1-ylphenol
Molecular formula	C₁₀H₁₄N₂O
Molecular weight	178.23 g/mol
Exact mass	178.1106
Grade	Reference Standard
HSN code	38229090
InChIKey	GPEOAEVZTOQXLG-UHFFFAOYSA-N
SMILES	C1CN(CCN1)C2=CC=C(C=C2)O
PubChem CID	92467

Physical properties
Physical form	Solid
LogP (XLogP3)	0.8
H-bond donors / acceptors	2 / 3
TPSA	35.5 Å²
Synonyms	p-(1-Piperazinyl)phenol, 4-(piperazin-1-yl)phenol, 4-(1-Piperazinyl)phenol, N-(4-hydroxyphenyl)piperazine, 4-Piperazinophenol, Phenol, 4-(1-piperazinyl)-, 4-piperazinylphenol, 4-(1-piperazino)phenol, 4-Piperazinyl phenol, 4-piperazin-1-yl-phenol, 4-hydroxy phenylpiperazine

Safety & hazard information (GHS)

Corrosive

Harmful / irritant

Signal word: Danger

Hazard statements

H314Causes severe skin burns and eye damage
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation

Precautionary statements: P260, P261, P264, P264 + P265, P271, P280, P301 + P330 + P331, P302 + P352, P302 + P361 + P354, P304 + P340, P305 + P351 + P338, P305 + P354 + P338, P316, P319, P321, P332 + P317, P337 + P317, P362 + P364, P363, P403 + P233, P405, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of 1-(4-Hydroxyphenyl)piperazine?

The CAS Registry Number of 1-(4-Hydroxyphenyl)piperazine is 56621-48-8. It is also known as p-(1-Piperazinyl)phenol, 4-(piperazin-1-yl)phenol, 4-(1-Piperazinyl)phenol.

What is the molecular formula and molecular weight of 1-(4-Hydroxyphenyl)piperazine?

1-(4-Hydroxyphenyl)piperazine has the molecular formula C10H14N2O and a molecular weight of 178.23 g/mol. Its IUPAC name is 4-piperazin-1-ylphenol.

What is 1-(4-Hydroxyphenyl)piperazine used for?

1-(4-Hydroxyphenyl)piperazine is supplied as a characterised reference material related to Posaconazole. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of 1-(4-Hydroxyphenyl)piperazine can I order?

We supply 1-(4-Hydroxyphenyl)piperazine in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with 1-(4-Hydroxyphenyl)piperazine?

Yes. Every lot of 1-(4-Hydroxyphenyl)piperazine is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can 1-(4-Hydroxyphenyl)piperazine be shipped internationally?

Yes. 1-(4-Hydroxyphenyl)piperazine is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.