N-Nitroso-desmethyl-imipramine

Name: N-Nitroso-desmethyl-imipramine
Brand: Vaqora Chemicals
SKU: VQ-026151

About N-Nitroso-desmethyl-imipramine

Listed under CAS 57164-17-7, N-Nitroso-desmethyl-imipramine is a nitrosamine impurity of Imipramine available from Vaqora Chemicals. Its molecular formula is C18H21N3O and its molecular weight is 295.4 g/mol. Its systematic (IUPAC) name is N-[3-(5,6-dihydrobenzo[b][1]benzazepin-11-yl)propyl]-N-methylnitrous amide. Alternative names: N-Nitrosodesipramine and N-Nitroso Desipramine.

The product is provided as a solid. Reference materials should be stored sealed and away from light and moisture, as specified on the accompanying COA. Under GHS it is labelled “Danger”, so handle it with suitable PPE and consult the SDS.

Laboratories use this nitrosamine standard to develop and validate highly sensitive LC-MS/MS methods, to confirm limits of detection and to document nitrosamine risk assessments in regulatory submissions. Typical end-use sectors are pharmaceutical manufacturing and academic and industrial research.

Vaqora Chemicals supplies N-Nitroso-desmethyl-imipramine in 10 mg, 25 mg, 50 mg and 100 mg packs, each shipped with a Certificate of Analysis (COA), and exports worldwide.

Typical applications

Nitrosamine risk assessment
Trace LC-MS/MS quantitation
Method validation (AMV)
Regulatory submissions

Industries

Related to Imipramine

View every impurity, metabolite and intermediate we list for Imipramine.

Imipramine impurities

Specifications & identifiers

Chemical identifiers
Product name	N-Nitroso-desmethyl-imipramine
Catalogue No.	VQ-026151
CAS Number	57164-17-7
IUPAC name	N-[3-(5,6-dihydrobenzo[b][1]benzazepin-11-yl)propyl]-N-methylnitrous amide
Molecular formula	C₁₈H₂₁N₃O
Molecular weight	295.4 g/mol
Exact mass	295.1685
Grade	Reference Standard
HSN code	38229090
InChIKey	OZJGLIPPPYOOCK-UHFFFAOYSA-N
SMILES	CN(CCCN1C2=CC=CC=C2CCC3=CC=CC=C31)N=O
PubChem CID	162811

Physical properties
Physical form	Solid
LogP (XLogP3)	5.3
H-bond donors / acceptors	0 / 4
TPSA	35.9 Å²
Synonyms	N-Nitrosodesipramine, N-Nitroso Desipramine, N-nitroso-desmethyl-imipramine (Mix of isomers), 5H-Dibenz(b,f)azepine-5-propanamine, 10,11-dihydro-N-methyl-N-nitroso-, 10,11-Dihydro-N-methyl-N-nitroso-5H-dibenz[b,f]azepine-5-propanamine, 10,11-Dihydro-N-methyl-N-nitroso-5H-dibenz(b,f)azepine-5-propanamine, 5H-Dibenz[b,f]azepine-5-propanamine, 10,11-dihydro-N-methyl-N-nitroso-, N-nitroso-desipramine, N-(3-(10,11-dihydro-5H-dibenzo[b,f]azepin-5-yl)propyl)-N-methylnitrous amide, N-[3-(10,11-Dihydro-5H-dibenzo[b,f]azepin-5-yl)propyl]-N-methylnitrous amide, Desipramine RC 8, N-[3-(5,6-dihydrobenzo[b][1]benzazepin-11-yl)propyl]-N-methylnitrousamide

Safety & hazard information (GHS)

Harmful / irritant

Health hazard

Signal word: Danger

Hazard statements

H302Harmful if swallowed
H336May cause drowsiness or dizziness
H370Causes damage to organs

Precautionary statements: P260, P261, P264, P270, P271, P301 + P317, P304 + P340, P308 + P316, P319, P321, P330, P403 + P233, P405, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of N-Nitroso-desmethyl-imipramine?

The CAS Registry Number of N-Nitroso-desmethyl-imipramine is 57164-17-7. It is also known as N-Nitrosodesipramine, N-Nitroso Desipramine, N-nitroso-desmethyl-imipramine (Mix of isomers).

What is the molecular formula and molecular weight of N-Nitroso-desmethyl-imipramine?

N-Nitroso-desmethyl-imipramine has the molecular formula C18H21N3O and a molecular weight of 295.4 g/mol. Its IUPAC name is N-[3-(5,6-dihydrobenzo[b][1]benzazepin-11-yl)propyl]-N-methylnitrous amide.

What is N-Nitroso-desmethyl-imipramine used for?

N-Nitroso-desmethyl-imipramine is supplied as a characterised reference material related to Imipramine. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of N-Nitroso-desmethyl-imipramine can I order?

We supply N-Nitroso-desmethyl-imipramine in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with N-Nitroso-desmethyl-imipramine?

Yes. Every lot of N-Nitroso-desmethyl-imipramine is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can N-Nitroso-desmethyl-imipramine be shipped internationally?

Yes. N-Nitroso-desmethyl-imipramine is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.