1-Acetyl Isonipecotoyl Chloride

About 1-Acetyl Isonipecotoyl Chloride

1-Acetyl Isonipecotoyl Chloride is an impurity of Iloperidone carrying the CAS registry number 59084-16-1. The compound has the formula C8H12ClNO2, corresponding to a molecular weight of 189.64 g/mol. Systematically, it is named 1-acetylpiperidine-4-carbonyl chloride. It is also known as 1-acetyl-4-piperidinecarbonyl chloride or N-acetylisonipecotoyl chloride.

It is supplied as a solid. Keep the vial tightly closed, protected from light and humidity, at the temperature stated on the Certificate of Analysis. Under GHS it is labelled “Danger”, so handle it with suitable PPE and consult the SDS.

As a characterised impurity of Iloperidone, it is used for analytical method development, method validation (AMV) and routine quality-control testing, and it supports ANDA and DMF regulatory filings. Our customers for this product work in pharmaceutical manufacturing and academic and industrial research.

We offer 1-Acetyl Isonipecotoyl Chloride in 10 mg, 25 mg, 50 mg and 100 mg packs with a batch-specific COA, and ship to customers worldwide.

Typical applications

Analytical method development
Method validation (AMV)
QC release testing
ANDA / DMF filings

Industries

Related to Iloperidone

View every impurity, metabolite and intermediate we list for Iloperidone.

Iloperidone impurities

Specifications & identifiers

Chemical identifiers
Product name	1-Acetyl Isonipecotoyl Chloride
Catalogue No.	VQ-039291
CAS Number	59084-16-1
IUPAC name	1-acetylpiperidine-4-carbonyl chloride
Molecular formula	C₈H₁₂ClNO₂
Molecular weight	189.64 g/mol
Exact mass	189.0557
Grade	Reference Standard
HSN code	38229090
InChIKey	OHCPVLJEAHBMEG-UHFFFAOYSA-N
SMILES	CC(=O)N1CCC(CC1)C(=O)Cl
PubChem CID	100950

Physical properties
Physical form	Solid
LogP (XLogP3)	0.7
H-bond donors / acceptors	0 / 2
TPSA	37.4 Å²
Synonyms	1-acetyl-4-piperidinecarbonyl chloride, N-acetylisonipecotoyl chloride, Acetylisonipecotoyl chloride, N-acetylisonipecotyl chloride, N-Acetyl isonipecotoyl chloride, 1-acetylisonipecotic acid chloride, N-acetylisonipecotic acid chloride, 4-Carboxychloro-N-acetoxypiperidine, N-acetyl-isonipecotic acid chloride

Safety & hazard information (GHS)

Corrosive

Harmful / irritant

Signal word: Danger

Hazard statements

H314Causes severe skin burns and eye damage
H318Causes serious eye damage
H319Causes serious eye irritation
H335May cause respiratory irritation

Precautionary statements: P260, P261, P264, P264 + P265, P271, P280, P301 + P330 + P331, P302 + P361 + P354, P304 + P340, P305 + P351 + P338, P305 + P354 + P338, P316, P317, P319, P321, P337 + P317, P363, P403 + P233, P405, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of 1-Acetyl Isonipecotoyl Chloride?

The CAS Registry Number of 1-Acetyl Isonipecotoyl Chloride is 59084-16-1. It is also known as 1-acetyl-4-piperidinecarbonyl chloride, N-acetylisonipecotoyl chloride, Acetylisonipecotoyl chloride.

What is the molecular formula and molecular weight of 1-Acetyl Isonipecotoyl Chloride?

1-Acetyl Isonipecotoyl Chloride has the molecular formula C8H12ClNO2 and a molecular weight of 189.64 g/mol. Its IUPAC name is 1-acetylpiperidine-4-carbonyl chloride.

What is 1-Acetyl Isonipecotoyl Chloride used for?

1-Acetyl Isonipecotoyl Chloride is supplied as a characterised reference material related to Iloperidone. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of 1-Acetyl Isonipecotoyl Chloride can I order?

We supply 1-Acetyl Isonipecotoyl Chloride in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with 1-Acetyl Isonipecotoyl Chloride?

Yes. Every lot of 1-Acetyl Isonipecotoyl Chloride is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can 1-Acetyl Isonipecotoyl Chloride be shipped internationally?

Yes. 1-Acetyl Isonipecotoyl Chloride is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.