Apremilast Impurity 37

About Apremilast Impurity 37

Apremilast Impurity 37 is an impurity of Apremilast carrying the CAS registry number 608142-27-4. The compound has the formula C12H19NO4S, corresponding to a molecular weight of 273.35 g/mol. Systematically, it is named (1R)-1-(3-ethoxy-4-methoxyphenyl)-2-methylsulfonylethanamine. It is also known as Apremilast Impurity 25.

The product is provided as a solid. Store the standard in its sealed vial, protected from light and moisture, and follow the storage condition printed on the COA. Under GHS it is labelled “Warning”, so handle it with suitable PPE and consult the SDS.

Pharmaceutical QC and development laboratories use this impurity standard of Apremilast to develop and validate HPLC methods, to set specification limits and to document impurity profiles in ANDA and DMF submissions. It is used across pharmaceutical manufacturing and academic and industrial research.

We offer Apremilast Impurity 37 in 10 mg, 25 mg, 50 mg and 100 mg packs with a batch-specific COA, and ship to customers worldwide. Stock is available for quick dispatch.

Typical applications

Analytical method development
Method validation (AMV)
QC release testing
ANDA / DMF filings

Industries

Related to Apremilast

View every impurity, metabolite and intermediate we list for Apremilast.

Apremilast impurities

Specifications & identifiers

Chemical identifiers
Product name	Apremilast Impurity 37
Catalogue No.	VQ-004436
CAS Number	608142-27-4
IUPAC name	(1R)-1-(3-ethoxy-4-methoxyphenyl)-2-methylsulfonylethanamine
Molecular formula	C₁₂H₁₉NO₄S
Molecular weight	273.35 g/mol
Exact mass	273.1035
Grade	Reference Standard
HSN code	38229090
InChIKey	BXUJVINGXQGNFD-JTQLQIEISA-N
SMILES	CCOC1=C(C=CC(=C1)[C@H](CS(=O)(=O)C)N)OC
PubChem CID	10195080

Physical properties
Physical form	Solid
LogP (XLogP3)	0.5
H-bond donors / acceptors	1 / 5
TPSA	87 Å²
Synonyms	(αR)-3-Ethoxy-4-methoxy-α-[(methylsulfonyl)methyl]benzenemethanamine, (R)-1-(3-Ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethanamine, (R)-1-(3-Ethoxy-4-Methoxyphenyl)-2-(Methylsulfonyl)ethylaMine, (R)-1-(3-Ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethan-1-amine, Apremilast Impurity 25, (?R)?-3-?Ethoxy-?4-?methoxy-??-?[(methylsulfonyl)?methyl]?-benzenemethanamine, (1R)-1-(3-ethoxy-4-methoxy-phenyl)-2-methylsulfonyl-ethanamine, (1R)-1-(3-ethoxy-4-methoxyphenyl)-2-methanesulfonyl-ethylamine, (1R)-1-(3-ethoxy-4-methoxyphenyl)-2-methanesulfonylethan-1-amine, (alphaR)-3-Ethoxy-4-methoxy-alpha-[(methylsulfonyl)methyl]benzenemethanamine, Benzenemethanamine, 3-ethoxy-4-methoxy-alpha-[(methylsulfonyl)methyl]-, (alphaR)-

Safety & hazard information (GHS)

Harmful / irritant

Signal word: Warning

Hazard statements

H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation

Precautionary statements: P261, P264, P264 + P265, P270, P271, P280, P301 + P317, P302 + P352, P304 + P340, P305 + P351 + P338, P319, P321, P330, P332 + P317, P337 + P317, P362 + P364, P403 + P233, P405, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of Apremilast Impurity 37?

The CAS Registry Number of Apremilast Impurity 37 is 608142-27-4. It is also known as (αR)-3-Ethoxy-4-methoxy-α-[(methylsulfonyl)methyl]benzenemethanamine, (R)-1-(3-Ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethanamine, (R)-1-(3-Ethoxy-4-Methoxyphenyl)-2-(Methylsulfonyl)ethylaMine.

What is the molecular formula and molecular weight of Apremilast Impurity 37?

Apremilast Impurity 37 has the molecular formula C12H19NO4S and a molecular weight of 273.35 g/mol. Its IUPAC name is (1R)-1-(3-ethoxy-4-methoxyphenyl)-2-methylsulfonylethanamine.

What is Apremilast Impurity 37 used for?

Apremilast Impurity 37 is supplied as a characterised reference material related to Apremilast. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of Apremilast Impurity 37 can I order?

We supply Apremilast Impurity 37 in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with Apremilast Impurity 37?

Yes. Every lot of Apremilast Impurity 37 is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can Apremilast Impurity 37 be shipped internationally?

Yes. Apremilast Impurity 37 is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.