21-Hydroxy-20-methylpregn-4-en-3-one

About 21-Hydroxy-20-methylpregn-4-en-3-one

21-Hydroxy-20-methylpregn-4-en-3-one is a metabolite or degradation product of Progesterone carrying the CAS registry number 60966-36-1. Its molecular formula is C22H34O2 and its molecular weight is 330.5 g/mol. Alternative names: Pregn-4-en-3-one, 21-hydroxy-20-methyl- and 20-hydroxymethyl-4-pregnen-3-one.

It is supplied as a solid. Reference materials should be stored sealed and away from light and moisture, as specified on the accompanying COA. Under GHS it is labelled “Danger”, so handle it with suitable PPE and consult the SDS.

It is used in metabolite identification, stability-indicating method development and impurity profiling of Progesterone, as well as in QC testing and ANDA/DMF documentation. It is used across pharmaceutical manufacturing and academic and industrial research.

We offer 21-Hydroxy-20-methylpregn-4-en-3-one in 10 mg, 25 mg, 50 mg and 100 mg packs with a batch-specific COA, and ship to customers worldwide.

Typical applications

Metabolite identification
Stability-indicating methods
Impurity profiling

Industries

Related to Progesterone

View every impurity, metabolite and intermediate we list for Progesterone.

Progesterone impurities

Specifications & identifiers

Chemical identifiers
Product name	21-Hydroxy-20-methylpregn-4-en-3-one
Catalogue No.	VQ-027644
CAS Number	60966-36-1
IUPAC name	(8S,9S,10R,13S,14S,17R)-17-(1-hydroxypropan-2-yl)-10,13-dimethyl-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-one
Molecular formula	C₂₂H₃₄O₂
Molecular weight	330.5 g/mol
Exact mass	330.2559
Grade	Reference Standard
HSN code	38229090
InChIKey	ZNWOYQVXPIEQRC-ZRFCQXGJSA-N
SMILES	CC(CO)[C@H]1CC[C@@H]2[C@@]1(CC[C@H]3[C@H]2CCC4=CC(=O)CC[C@]34C)C
PubChem CID	6454094

Physical properties
Physical form	Solid
LogP (XLogP3)	4.7
H-bond donors / acceptors	1 / 2
TPSA	37.3 Å²

Safety & hazard information (GHS)

Health hazard

Signal word: Danger

Hazard statements

H351Suspected of causing cancer
H360May damage fertility or the unborn child
H362May cause harm to breast-fed children

Precautionary statements: P203, P260, P263, P264, P270, P280, P318, P405, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of 21-Hydroxy-20-methylpregn-4-en-3-one?

The CAS Registry Number of 21-Hydroxy-20-methylpregn-4-en-3-one is 60966-36-1. It is also known as Pregn-4-en-3-one, 21-hydroxy-20-methyl-, 20-hydroxymethyl-4-pregnen-3-one.

What is the molecular formula and molecular weight of 21-Hydroxy-20-methylpregn-4-en-3-one?

21-Hydroxy-20-methylpregn-4-en-3-one has the molecular formula C22H34O2 and a molecular weight of 330.5 g/mol. Its IUPAC name is (8S,9S,10R,13S,14S,17R)-17-(1-hydroxypropan-2-yl)-10,13-dimethyl-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-one.

What is 21-Hydroxy-20-methylpregn-4-en-3-one used for?

21-Hydroxy-20-methylpregn-4-en-3-one is supplied as a characterised reference material related to Progesterone. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of 21-Hydroxy-20-methylpregn-4-en-3-one can I order?

We supply 21-Hydroxy-20-methylpregn-4-en-3-one in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with 21-Hydroxy-20-methylpregn-4-en-3-one?

Yes. Every lot of 21-Hydroxy-20-methylpregn-4-en-3-one is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can 21-Hydroxy-20-methylpregn-4-en-3-one be shipped internationally?

Yes. 21-Hydroxy-20-methylpregn-4-en-3-one is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.