Tri-o-tolylphosphine oxide

Name: Tri-o-tolylphosphine oxide
Brand: Vaqora Chemicals
SKU: VQ-048165

About Tri-o-tolylphosphine oxide

Vaqora Chemicals supplies Tri-o-tolylphosphine oxide, a process intermediate or related compound of Eletriptan registered under CAS number 6163-63-9. Its molecular formula is C21H21OP and its molecular weight is 320.4 g/mol. The IUPAC name is 1-bis(2-methylphenyl)phosphoryl-2-methylbenzene. It is also known as Tris(o-tolyl)phosphine oxide or Phosphine oxide, tri-o-tolyl-.

It is supplied as a solid. Reference materials should be stored sealed and away from light and moisture, as specified on the accompanying COA. Handle it with standard laboratory precautions and appropriate personal protective equipment.

Process chemists and analysts use it when developing synthetic routes to Eletriptan, tracking process-related impurities and validating analytical methods. It is used across pharmaceutical manufacturing and academic and industrial research.

We offer Tri-o-tolylphosphine oxide in 10 mg, 25 mg, 50 mg and 100 mg packs with a batch-specific COA, and ship to customers worldwide.

Typical applications

API route development
Impurity fate & purge studies
Analytical method development

Industries

Related to Eletriptan

View every impurity, metabolite and intermediate we list for Eletriptan.

Eletriptan impurities

Specifications & identifiers

Chemical identifiers
Product name	Tri-o-tolylphosphine oxide
Catalogue No.	VQ-048165
CAS Number	6163-63-9
IUPAC name	1-bis(2-methylphenyl)phosphoryl-2-methylbenzene
Molecular formula	C₂₁H₂₁OP
Molecular weight	320.4 g/mol
Exact mass	320.133
InChIKey	VGSVITFVAXDZAL-UHFFFAOYSA-N
SMILES	CC1=CC=CC=C1P(=O)(C2=CC=CC=C2C)C3=CC=CC=C3C
PubChem CID	326944

Physical properties
Physical form	Solid
LogP (XLogP3)	5.1
H-bond donors / acceptors	0 / 1
TPSA	17.1 Å²
Synonyms	Tris(o-tolyl)phosphine oxide, Phosphine oxide, tri-o-tolyl-, tris(2-methylphenyl)phosphine oxide, Phosphine oxide, tris(2-methylphenyl)-, Tris(2-tolyl)phosphine oxide, Tri(o-methylphenyl)phosphine monoxide, 1-(bis-o-tolylphosphoryl)-2-methyl-benzene, Tris(2-methylphenyl)(oxo)-lambda~5~-phosphane

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of Tri-o-tolylphosphine oxide?

The CAS Registry Number of Tri-o-tolylphosphine oxide is 6163-63-9. It is also known as Tris(o-tolyl)phosphine oxide, Phosphine oxide, tri-o-tolyl-, tris(2-methylphenyl)phosphine oxide.

What is the molecular formula and molecular weight of Tri-o-tolylphosphine oxide?

Tri-o-tolylphosphine oxide has the molecular formula C21H21OP and a molecular weight of 320.4 g/mol. Its IUPAC name is 1-bis(2-methylphenyl)phosphoryl-2-methylbenzene.

What is Tri-o-tolylphosphine oxide used for?

Tri-o-tolylphosphine oxide is supplied as a characterised reference material related to Eletriptan. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of Tri-o-tolylphosphine oxide can I order?

We supply Tri-o-tolylphosphine oxide, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with Tri-o-tolylphosphine oxide?

Yes. Every lot of Tri-o-tolylphosphine oxide is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can Tri-o-tolylphosphine oxide be shipped internationally?

Yes. We export Tri-o-tolylphosphine oxide worldwide by air and sea freight or express courier, on EXW, FOB, CIF, CFR or DAP Incoterms, with full export documentation.