6-Methyl-2,4(1H,3H)-pyrimidinedione

About 6-Methyl-2,4(1H,3H)-pyrimidinedione

6-Methyl-2,4(1H,3H)-pyrimidinedione is a process intermediate or related compound of Fluorouracil carrying the CAS registry number 626-48-2. Formula C5H6N2O2, molecular weight 126.11 g/mol. Systematically, it is named 6-methyl-1H-pyrimidine-2,4-dione. It is also known as 6-Methyluracil or Pseudothymine.

It is supplied as a solid. Reference materials should be stored sealed and away from light and moisture, as specified on the accompanying COA. Under GHS it is labelled “Warning”, so handle it with suitable PPE and consult the SDS.

It is a process intermediate or related compound in the synthesis of Fluorouracil, useful for route development, impurity fate-and-purge studies and analytical method development. Buyers come mainly from pharmaceutical manufacturing and academic and industrial research.

We offer 6-Methyl-2,4(1H,3H)-pyrimidinedione in 10 mg, 25 mg, 50 mg and 100 mg packs with a batch-specific COA, and ship to customers worldwide.

Typical applications

API route development
Impurity fate & purge studies
Analytical method development
Fine chemical synthesis

Industries

Related to Fluorouracil

View every impurity, metabolite and intermediate we list for Fluorouracil.

Fluorouracil impurities

Specifications & identifiers

Chemical identifiers
Product name	6-Methyl-2,4(1H,3H)-pyrimidinedione
Catalogue No.	VQ-039318
CAS Number	626-48-2
IUPAC name	6-methyl-1H-pyrimidine-2,4-dione
Molecular formula	C₅H₆N₂O₂
Molecular weight	126.11 g/mol
Exact mass	126.0429
HSN code	2933
InChIKey	SHVCSCWHWMSGTE-UHFFFAOYSA-N
SMILES	CC1=CC(=O)NC(=O)N1
PubChem CID	12283

Physical properties
Physical form	Solid
LogP (XLogP3)	-0.8
H-bond donors / acceptors	2 / 2
TPSA	58.2 Å²
Synonyms	6-Methyluracil, Pseudothymine, 4-Methyluracil, 2,4(1H,3H)-Pyrimidinedione, 6-methyl-, Uracil, 6-methyl-, AWD-23-15, 2,4-Dihydroxy-6-methylpyrimidine, 6-methylpyrimidine-2,4(1H,3H)-dione, 6-methylpyrimidine-2,4-diol, 2,4-Pyrimidinediol, 6-methyl-, 2(1H)-Pyrimidinone, 4-hydroxy-6-methyl-

Safety & hazard information (GHS)

Health hazard

Signal word: Warning

Hazard statements

H361Suspected of damaging fertility or the unborn child

Precautionary statements: P203, P280, P318, P405, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of 6-Methyl-2,4(1H,3H)-pyrimidinedione?

The CAS Registry Number of 6-Methyl-2,4(1H,3H)-pyrimidinedione is 626-48-2. It is also known as 6-Methyluracil, Pseudothymine, 4-Methyluracil.

What is the molecular formula and molecular weight of 6-Methyl-2,4(1H,3H)-pyrimidinedione?

6-Methyl-2,4(1H,3H)-pyrimidinedione has the molecular formula C5H6N2O2 and a molecular weight of 126.11 g/mol. Its IUPAC name is 6-methyl-1H-pyrimidine-2,4-dione.

What is 6-Methyl-2,4(1H,3H)-pyrimidinedione used for?

6-Methyl-2,4(1H,3H)-pyrimidinedione is supplied as a characterised reference material related to Fluorouracil. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of 6-Methyl-2,4(1H,3H)-pyrimidinedione can I order?

We supply 6-Methyl-2,4(1H,3H)-pyrimidinedione, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with 6-Methyl-2,4(1H,3H)-pyrimidinedione?

Yes. Every lot of 6-Methyl-2,4(1H,3H)-pyrimidinedione is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can 6-Methyl-2,4(1H,3H)-pyrimidinedione be shipped internationally?

Yes. 6-Methyl-2,4(1H,3H)-pyrimidinedione is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.