4-Chloropropiophenone

About 4-Chloropropiophenone

4-Chloropropiophenone is a process intermediate or related compound of Bupropion carrying the CAS registry number 6285-05-8. With the molecular formula C9H9ClO, it has a molar mass of 168.62 g/mol. The IUPAC name is 1-(4-chlorophenyl)propan-1-one. It is also known as p-Chloropropiophenone or 1-Propanone, 1-(4-chlorophenyl)-.

The product is provided as a solid. Reference materials should be stored sealed and away from light and moisture, as specified on the accompanying COA. Under GHS it is labelled “Warning”, so handle it with suitable PPE and consult the SDS.

It is a process intermediate or related compound in the synthesis of Bupropion, useful for route development, impurity fate-and-purge studies and analytical method development. It is used across pharmaceutical manufacturing and academic and industrial research.

Available in 10 mg, 25 mg, 50 mg and 100 mg packs, 4-Chloropropiophenone is dispatched with a Certificate of Analysis (COA) to destinations worldwide.

Typical applications

API route development
Impurity fate & purge studies
Analytical method development

Industries

Related to Bupropion

View every impurity, metabolite and intermediate we list for Bupropion.

Bupropion impurities

Specifications & identifiers

Chemical identifiers
Product name	4-Chloropropiophenone
Catalogue No.	VQ-047643
CAS Number	6285-05-8
IUPAC name	1-(4-chlorophenyl)propan-1-one
Molecular formula	C₉H₉ClO
Molecular weight	168.62 g/mol
Exact mass	168.0342
InChIKey	ADCYRBXQAJXJTD-UHFFFAOYSA-N
SMILES	CCC(=O)C1=CC=C(C=C1)Cl
PubChem CID	22697

Physical properties
Physical form	Solid
LogP (XLogP3)	3
H-bond donors / acceptors	0 / 1
TPSA	17.1 Å²
Synonyms	p-Chloropropiophenone, 1-Propanone, 1-(4-chlorophenyl)-, Ethyl p-chlorophenyl ketone, Propiophenone, p-chloro-, Ethyl 4-chlorophenyl ketone, 1-(4-Chlorophenyl)-1-propanone, 1-(4-chlorophenyl)propane-1-one, 4-Chlorophenyl Ethyl Ketone, 1-(4-chloropenyl)propan-1-one

Safety & hazard information (GHS)

Harmful / irritant

Signal word: Warning

Hazard statements

H302Harmful if swallowed
H315Causes skin irritation
H317May cause an allergic skin reaction
H319Causes serious eye irritation
H335May cause respiratory irritation

Precautionary statements: P261, P264, P264 + P265, P270, P271, P272, P280, P301 + P317, P302 + P352, P304 + P340, P305 + P351 + P338, P319, P321, P330, P332 + P317, P333 + P317, P337 + P317, P362 + P364, P403 + P233, P405, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of 4-Chloropropiophenone?

The CAS Registry Number of 4-Chloropropiophenone is 6285-05-8. It is also known as p-Chloropropiophenone, 1-Propanone, 1-(4-chlorophenyl)-, Ethyl p-chlorophenyl ketone.

What is the molecular formula and molecular weight of 4-Chloropropiophenone?

4-Chloropropiophenone has the molecular formula C9H9ClO and a molecular weight of 168.62 g/mol. Its IUPAC name is 1-(4-chlorophenyl)propan-1-one.

What is 4-Chloropropiophenone used for?

4-Chloropropiophenone is supplied as a characterised reference material related to Bupropion. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of 4-Chloropropiophenone can I order?

We supply 4-Chloropropiophenone, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with 4-Chloropropiophenone?

Yes. Every lot of 4-Chloropropiophenone is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can 4-Chloropropiophenone be shipped internationally?

Yes. 4-Chloropropiophenone is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.