8-(Benzyloxy)-5-(2-chloroacetyl)quinolin-2(1H… 63404-86-4

Name: 8-(Benzyloxy)-5-(2-chloroacetyl)quinolin-2(1H)-one
Brand: Vaqora Chemicals
SKU: VQ-037689

About 8-(Benzyloxy)-5-(2-chloroacetyl)quinolin-2(1H)-one

8-(Benzyloxy)-5-(2-chloroacetyl)quinolin-2(1H)-one (CAS 63404-86-4) is an impurity of Indacaterol offered by Vaqora Chemicals. With the molecular formula C18H14ClNO3, it has a molar mass of 327.8 g/mol. Its systematic (IUPAC) name is 5-(2-chloroacetyl)-8-phenylmethoxy-1H-quinolin-2-one. It is also known as 8-Benzyloxy-5-chloroacetylcarbostyril.

It is supplied as a solid. Reference materials should be stored sealed and away from light and moisture, as specified on the accompanying COA. It carries the GHS signal word “Warning” with 4 hazard statements. Review the Safety Data Sheet before use.

Pharmaceutical QC and development laboratories use this impurity standard of Indacaterol to develop and validate HPLC methods, to set specification limits and to document impurity profiles in ANDA and DMF submissions. Buyers come mainly from pharmaceutical manufacturing and academic and industrial research.

We offer 8-(Benzyloxy)-5-(2-chloroacetyl)quinolin-2(1H)-one in 10 mg, 25 mg, 50 mg and 100 mg packs with a batch-specific COA, and ship to customers worldwide.

Typical applications

Analytical method development
Method validation (AMV)
QC release testing
ANDA / DMF filings

Industries

Related to Indacaterol

View every impurity, metabolite and intermediate we list for Indacaterol.

Indacaterol impurities

Specifications & identifiers

Chemical identifiers
Product name	8-(Benzyloxy)-5-(2-chloroacetyl)quinolin-2(1H)-one
Catalogue No.	VQ-037689
CAS Number	63404-86-4
IUPAC name	5-(2-chloroacetyl)-8-phenylmethoxy-1H-quinolin-2-one
Molecular formula	C₁₈H₁₄ClNO₃
Molecular weight	327.8 g/mol
Exact mass	327.0662
Grade	Reference Standard
HSN code	38229090
InChIKey	AUFKEUKWVZCLQD-UHFFFAOYSA-N
SMILES	C1=CC=C(C=C1)COC2=C3C(=C(C=C2)C(=O)CCl)C=CC(=O)N3
PubChem CID	10903550

Physical properties
Physical form	Solid
LogP (XLogP3)	3.1
H-bond donors / acceptors	1 / 3
TPSA	55.4 Å²
Synonyms	5-(Chloroacetyl)-8-(phenylmethoxy)-2(1H)-quinolinone, 8-benzyloxy-5-(2-chloroacetyl)-1h-quinolin-2-one, 8-benzyloxy-5-(2-chloro-acetyl)-1H-quinolin-2-one, 8-Benzyloxy-5-chloroacetylcarbostyril, 5-(Chloroacetyl)-8-(benzyloxy)-2(1h)-quinolinone, 8-(Benzyloxy)-5-(chloroacetyl)quinolin-2(1H)-one, 8-(phenylmethoxy)-5-(alpha-chloroacetyl)-(1h)-quinolin-2-one

Safety & hazard information (GHS)

Harmful / irritant

Signal word: Warning

Hazard statements

H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation

Precautionary statements: P261, P264, P264 + P265, P270, P271, P280, P301 + P317, P302 + P352, P304 + P340, P305 + P351 + P338, P319, P321, P330, P332 + P317, P337 + P317, P362 + P364, P403 + P233, P405, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of 8-(Benzyloxy)-5-(2-chloroacetyl)quinolin-2(1H)-one?

The CAS Registry Number of 8-(Benzyloxy)-5-(2-chloroacetyl)quinolin-2(1H)-one is 63404-86-4. It is also known as 5-(Chloroacetyl)-8-(phenylmethoxy)-2(1H)-quinolinone, 8-benzyloxy-5-(2-chloroacetyl)-1h-quinolin-2-one, 8-benzyloxy-5-(2-chloro-acetyl)-1H-quinolin-2-one.

What is the molecular formula and molecular weight of 8-(Benzyloxy)-5-(2-chloroacetyl)quinolin-2(1H)-one?

8-(Benzyloxy)-5-(2-chloroacetyl)quinolin-2(1H)-one has the molecular formula C18H14ClNO3 and a molecular weight of 327.8 g/mol. Its IUPAC name is 5-(2-chloroacetyl)-8-phenylmethoxy-1H-quinolin-2-one.

What is 8-(Benzyloxy)-5-(2-chloroacetyl)quinolin-2(1H)-one used for?

8-(Benzyloxy)-5-(2-chloroacetyl)quinolin-2(1H)-one is supplied as a characterised reference material related to Indacaterol. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of 8-(Benzyloxy)-5-(2-chloroacetyl)quinolin-2(1H)-one can I order?

We supply 8-(Benzyloxy)-5-(2-chloroacetyl)quinolin-2(1H)-one in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with 8-(Benzyloxy)-5-(2-chloroacetyl)quinolin-2(1H)-one?

Yes. Every lot of 8-(Benzyloxy)-5-(2-chloroacetyl)quinolin-2(1H)-one is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can 8-(Benzyloxy)-5-(2-chloroacetyl)quinolin-2(1H)-one be shipped internationally?

Yes. 8-(Benzyloxy)-5-(2-chloroacetyl)quinolin-2(1H)-one is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.