5-Amino-2-Methylbenzotrifluoride

Name: 5-Amino-2-Methylbenzotrifluoride
Brand: Vaqora Chemicals
SKU: VQ-040462

About 5-Amino-2-Methylbenzotrifluoride

5-Amino-2-Methylbenzotrifluoride (CAS 65934-74-9) is an impurity of Avacopan offered by Vaqora Chemicals. Its molecular formula is C8H8F3N and its molecular weight is 175.15 g/mol. The IUPAC name is 4-methyl-3-(trifluoromethyl)aniline. It is also known as 4-Methyl-3-trifluoromethylaniline or 4-methyl-3-(trifluoromethyl)phenylamine.

The product is provided as a solid. Keep the vial tightly closed, protected from light and humidity, at the temperature stated on the Certificate of Analysis. Under GHS it is labelled “Warning”, so handle it with suitable PPE and consult the SDS.

Pharmaceutical QC and development laboratories use this impurity standard of Avacopan to develop and validate HPLC methods, to set specification limits and to document impurity profiles in ANDA and DMF submissions. It is used across pharmaceutical manufacturing and academic and industrial research.

Vaqora Chemicals supplies 5-Amino-2-Methylbenzotrifluoride in 10 mg, 25 mg, 50 mg and 100 mg packs, each shipped with a Certificate of Analysis (COA), and exports worldwide.

Typical applications

Analytical method development
Method validation (AMV)
QC release testing
ANDA / DMF filings

Industries

Related to Avacopan

View every impurity, metabolite and intermediate we list for Avacopan.

Avacopan impurities

Specifications & identifiers

Chemical identifiers
Product name	5-Amino-2-Methylbenzotrifluoride
Catalogue No.	VQ-040462
CAS Number	65934-74-9
IUPAC name	4-methyl-3-(trifluoromethyl)aniline
Molecular formula	C₈H₈F₃N
Molecular weight	175.15 g/mol
Exact mass	175.0609
Grade	Reference Standard
HSN code	38229090
InChIKey	JBCDCYFEJQHTTA-UHFFFAOYSA-N
SMILES	CC1=C(C=C(C=C1)N)C(F)(F)F
PubChem CID	2737715

Physical properties
Physical form	Solid
LogP (XLogP3)	2.5
H-bond donors / acceptors	1 / 4
TPSA	26 Å²
Synonyms	4-Methyl-3-trifluoromethylaniline, 4-methyl-3-(trifluoromethyl)phenylamine, Benzenamine, 4-methyl-3-(trifluoromethyl)-, 4-Methyl-5-Trifluoromethylaniline, 4-methyl-3-(trifluoromethyl)benzenamine, 4-methyl-3-trifluoromethyl-aniline

Safety & hazard information (GHS)

Harmful / irritant

Signal word: Warning

Hazard statements

H302Harmful if swallowed
H312Harmful in contact with skin
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation

Precautionary statements: P261, P264, P264 + P265, P270, P271, P280, P301 + P317, P302 + P352, P304 + P340, P305 + P351 + P338, P317, P319, P321, P330, P332 + P317, P337 + P317, P362 + P364, P403 + P233, P405, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of 5-Amino-2-Methylbenzotrifluoride?

The CAS Registry Number of 5-Amino-2-Methylbenzotrifluoride is 65934-74-9. It is also known as 4-Methyl-3-trifluoromethylaniline, 4-methyl-3-(trifluoromethyl)phenylamine, Benzenamine, 4-methyl-3-(trifluoromethyl)-.

What is the molecular formula and molecular weight of 5-Amino-2-Methylbenzotrifluoride?

5-Amino-2-Methylbenzotrifluoride has the molecular formula C8H8F3N and a molecular weight of 175.15 g/mol. Its IUPAC name is 4-methyl-3-(trifluoromethyl)aniline.

What is 5-Amino-2-Methylbenzotrifluoride used for?

5-Amino-2-Methylbenzotrifluoride is supplied as a characterised reference material related to Avacopan. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of 5-Amino-2-Methylbenzotrifluoride can I order?

We supply 5-Amino-2-Methylbenzotrifluoride in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with 5-Amino-2-Methylbenzotrifluoride?

Yes. Every lot of 5-Amino-2-Methylbenzotrifluoride is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can 5-Amino-2-Methylbenzotrifluoride be shipped internationally?

Yes. 5-Amino-2-Methylbenzotrifluoride is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.