N-Didesmethyl Loperamide

About N-Didesmethyl Loperamide

N-Didesmethyl Loperamide is a metabolite or degradation product of Loperamide carrying the CAS registry number 66164-06-5. The compound has the formula C27H29ClN2O2, corresponding to a molecular weight of 449.0 g/mol. Its systematic (IUPAC) name is 4-[4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl]-2,2-diphenylbutanamide. Alternative names: Loperamid-M didesmethyl.

The product is provided as a solid. Keep the vial tightly closed, protected from light and humidity, at the temperature stated on the Certificate of Analysis. Good laboratory practice and suitable PPE are recommended during handling.

It is used in metabolite identification, stability-indicating method development and impurity profiling of Loperamide, as well as in QC testing and ANDA/DMF documentation. Our customers for this product work in pharmaceutical manufacturing and academic and industrial research.

We offer N-Didesmethyl Loperamide in 10 mg, 25 mg, 50 mg and 100 mg packs with a batch-specific COA, and ship to customers worldwide.

Typical applications

Metabolite identification
Stability-indicating methods
Impurity profiling

Industries

Related to Loperamide

View every impurity, metabolite and intermediate we list for Loperamide.

Loperamide impurities

Specifications & identifiers

Chemical identifiers
Product name	N-Didesmethyl Loperamide
Catalogue No.	VQ-038110
CAS Number	66164-06-5
IUPAC name	4-[4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl]-2,2-diphenylbutanamide
Molecular formula	C₂₇H₂₉ClN₂O₂
Molecular weight	449 g/mol
Exact mass	448.1918
Grade	Reference Standard
HSN code	38229090
InChIKey	PXJHDOGGBLQFRX-UHFFFAOYSA-N
SMILES	C1CN(CCC1(C2=CC=C(C=C2)Cl)O)CCC(C3=CC=CC=C3)(C4=CC=CC=C4)C(=O)N
PubChem CID	25129795

Physical properties
Physical form	Solid
LogP (XLogP3)	4.4
H-bond donors / acceptors	2 / 3
TPSA	66.6 Å²

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of N-Didesmethyl Loperamide?

The CAS Registry Number of N-Didesmethyl Loperamide is 66164-06-5. It is also known as 4-(4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl)-2,2-diphenylbutanamide, Loperamid-M didesmethyl, 4-[4-(4-Chlorophenyl)-4-hydroxy-1-piperidinyl]-2,2-diphenylbutanamide.

What is the molecular formula and molecular weight of N-Didesmethyl Loperamide?

N-Didesmethyl Loperamide has the molecular formula C27H29ClN2O2 and a molecular weight of 449 g/mol. Its IUPAC name is 4-[4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl]-2,2-diphenylbutanamide.

What is N-Didesmethyl Loperamide used for?

N-Didesmethyl Loperamide is supplied as a characterised reference material related to Loperamide. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of N-Didesmethyl Loperamide can I order?

We supply N-Didesmethyl Loperamide in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with N-Didesmethyl Loperamide?

Yes. Every lot of N-Didesmethyl Loperamide is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can N-Didesmethyl Loperamide be shipped internationally?

Yes. We export N-Didesmethyl Loperamide worldwide by air and sea freight or express courier, on EXW, FOB, CIF, CFR or DAP Incoterms, with full export documentation.