Acetyl ketene

Name: Acetyl ketene
Brand: Vaqora Chemicals
SKU: VQ-039020

About Acetyl ketene

Listed under CAS 674-82-8, Acetyl ketene is an impurity of Manidipine available from Vaqora Chemicals. Its molecular formula is C4H4O2 and its molecular weight is 84.07 g/mol. Its systematic (IUPAC) name is 4-methylideneoxetan-2-one. Common synonyms include 4-Methylene-oxetan-2-one and Diketene.

The product is provided as a solid. Reference materials should be stored sealed and away from light and moisture, as specified on the accompanying COA. It carries the GHS signal word “Warning” with 2 hazard statements. Review the Safety Data Sheet before use.

Pharmaceutical QC and development laboratories use this impurity standard of Manidipine to develop and validate HPLC methods, to set specification limits and to document impurity profiles in ANDA and DMF submissions. Our customers for this product work in pharmaceutical manufacturing and academic and industrial research.

We offer Acetyl ketene in 10 mg, 25 mg, 50 mg and 100 mg packs with a batch-specific COA, and ship to customers worldwide.

Typical applications

Analytical method development
Method validation (AMV)
QC release testing
ANDA / DMF filings

Industries

Related to Manidipine

View every impurity, metabolite and intermediate we list for Manidipine.

Manidipine impurities

Specifications & identifiers

Chemical identifiers
Product name	Acetyl ketene
Catalogue No.	VQ-039020
CAS Number	674-82-8
IUPAC name	4-methylideneoxetan-2-one
Molecular formula	C₄H₄O₂
Molecular weight	84.07 g/mol
Exact mass	84.0211
Grade	Reference Standard
HSN code	38229090
InChIKey	WASQWSOJHCZDFK-UHFFFAOYSA-N
SMILES	C=C1CC(=O)O1
PubChem CID	12661

Physical properties
Physical form	Solid
LogP (XLogP3)	0.3
H-bond donors / acceptors	0 / 2
TPSA	26.3 Å²
Synonyms	4-Methylene-oxetan-2-one, Diketene, 4-Methylene-2-oxetanone, 2-Oxetanone, 4-methylene-, Ketene, dimer, 3-Buteno-beta-lactone, Vinylaceto-beta-lactone, 3-Butenoic acid, 3-hydroxy-, beta-lactone, 4-methyleneoxetan-2-one, Ethenone, dimer, Ketene dimer, Vinylaceto-.beta.-lactone

Safety & hazard information (GHS)

Flammable

Harmful / irritant

Signal word: Warning

Hazard statements

H226Flammable liquid and vapor
H332Harmful if inhaled

Precautionary statements: P210, P233, P240, P241, P242, P243, P261, P271, P280, P303 + P361 + P353, P304 + P340, P317, P370 + P378, P403 + P235, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of Acetyl ketene?

The CAS Registry Number of Acetyl ketene is 674-82-8. It is also known as 4-Methylene-oxetan-2-one, Diketene, 4-Methylene-2-oxetanone.

What is the molecular formula and molecular weight of Acetyl ketene?

Acetyl ketene has the molecular formula C4H4O2 and a molecular weight of 84.07 g/mol. Its IUPAC name is 4-methylideneoxetan-2-one.

What is Acetyl ketene used for?

Acetyl ketene is supplied as a characterised reference material related to Manidipine. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of Acetyl ketene can I order?

We supply Acetyl ketene in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with Acetyl ketene?

Yes. Every lot of Acetyl ketene is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can Acetyl ketene be shipped internationally?

Yes. Acetyl ketene is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.