Jacobine

Name: Jacobine
Brand: Vaqora Chemicals
SKU: VQ-032661

About Jacobine

Vaqora Chemicals supplies Jacobine, a high-purity reference standard of Jacobine registered under CAS number 6870-67-3. Its molecular formula is C18H25NO6 and its molecular weight is 351.4 g/mol.

It is supplied as a solid. Keep the vial tightly closed, protected from light and humidity, at the temperature stated on the Certificate of Analysis. It carries the GHS signal word “Danger” with 5 hazard statements. Review the Safety Data Sheet before use.

As a reference sample of Jacobine, it is used for identification, assay and impurity-profiling work during analytical method development, validation (AMV) and routine QC. It is used across pharmaceutical manufacturing and academic and industrial research.

We offer Jacobine in 10 mg, 25 mg, 50 mg and 100 mg packs with a batch-specific COA, and ship to customers worldwide.

Typical applications

Identification & assay
Method development & validation
QC reference material

Industries

Related to Jacobine

View every impurity, metabolite and intermediate we list for Jacobine.

Jacobine impurities

Specifications & identifiers

Chemical identifiers
Product name	Jacobine
Catalogue No.	VQ-032661
CAS Number	6870-67-3
IUPAC name	(1R,3'S,4S,6R,7R,17R)-7-hydroxy-3',6,7-trimethylspiro[2,9-dioxa-14-azatricyclo[9.5.1.014,17]heptadec-11-ene-4,2'-oxirane]-3,8-dione
Molecular formula	C₁₈H₂₅NO₆
Molecular weight	351.4 g/mol
Exact mass	351.1682
Grade	Reference Standard
HSN code	38229090
InChIKey	IAPHXJRHXBQDQJ-WKMWQDDRSA-N
SMILES	C[C@@H]1C[C@]2([C@@H](O2)C)C(=O)O[C@@H]3CCN4[C@@H]3C(=CC4)COC(=O)[C@]1(C)O
PubChem CID	442741

Physical properties
Physical form	Solid
LogP (XLogP3)	0.3
H-bond donors / acceptors	1 / 7
TPSA	88.6 Å²
Synonyms	15,20-Epoxy-15,20-dihydro-12-hydroxysenecionan-11,16-dione, (15alpha,20R)15,20-Epoxy-15,20-dihydro-12-hydroxysenecionan-11,16-dione, Senecionan-11,16-dione, 15,20-epoxy-15,20-dihydro-12-hydroxy-, (15alpha,20R)-, (15 alpha,20R)15,20-epoxy-15,20-dihydro-12-hydroxy-senecionan-11,16-dione, 12beta-Hydroxy-12alpha,13beta-dimethylsenec-1-enine-15S-spiro-2'-(3'R-methyloxiran), Senecionan-11,16-dione, 15,20-epoxy-15,20-dihydro-12-hydroxy-, (15-alpha,20S)-, (15S,20S)-12-Hydroxy-15,20-dihydro-15,20-epoxysenecionan-11,16-dione, (15alpha,20R)15,20-Epoxy-15,20-dihydro-12-hydroxy-senecionan-11,16-dione

Safety & hazard information (GHS)

Toxic

Harmful / irritant

Signal word: Danger

Hazard statements

H300+H310+H330Fatal if swallowed, in contact with skin or if inhaled
H300Fatal if swallowed
H302Harmful if swallowed
H310Fatal in contact with skin
H330Fatal if inhaled

Precautionary statements: P260, P262, P264, P270, P271, P280, P284, P301 + P316, P301 + P317, P302 + P352, P304 + P340, P316, P320, P321, P330, P361 + P364, P403 + P233, P405, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of Jacobine?

The CAS Registry Number of Jacobine is 6870-67-3. It is also known as 15,20-Epoxy-15,20-dihydro-12-hydroxysenecionan-11,16-dione, (15alpha,20R)15,20-Epoxy-15,20-dihydro-12-hydroxysenecionan-11,16-dione, Senecionan-11,16-dione, 15,20-epoxy-15,20-dihydro-12-hydroxy-, (15alpha,20R)-.

What is the molecular formula and molecular weight of Jacobine?

Jacobine has the molecular formula C18H25NO6 and a molecular weight of 351.4 g/mol. Its IUPAC name is (1R,3'S,4S,6R,7R,17R)-7-hydroxy-3',6,7-trimethylspiro[2,9-dioxa-14-azatricyclo[9.5.1.014,17]heptadec-11-ene-4,2'-oxirane]-3,8-dione.

What is Jacobine used for?

Jacobine is supplied as a characterised reference material related to Jacobine. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of Jacobine can I order?

We supply Jacobine in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with Jacobine?

Yes. Every lot of Jacobine is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can Jacobine be shipped internationally?

Yes. Jacobine is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.