Astemizole

About Astemizole

Astemizole is a high-purity reference standard of Astemizole carrying the CAS registry number 68844-77-9. With the molecular formula C28H31FN4O, it has a molar mass of 458.6 g/mol. Its systematic (IUPAC) name is 1-[(4-fluorophenyl)methyl]-N-[1-[2-(4-methoxyphenyl)ethyl]piperidin-4-yl]benzimidazol-2-amine. It is also known as Hismanal or Paralergin.

It is supplied as a solid. Reference materials should be stored sealed and away from light and moisture, as specified on the accompanying COA. The GHS classification uses the signal word “Warning”, so appropriate gloves, eye protection and ventilation are recommended.

As a reference sample of Astemizole, it is used for identification, assay and impurity-profiling work during analytical method development, validation (AMV) and routine QC. It is used across pharmaceutical manufacturing and academic and industrial research.

We offer Astemizole in 10 mg, 25 mg, 50 mg and 100 mg packs with a batch-specific COA, and ship to customers worldwide.

Typical applications

Identification & assay
Method development & validation
QC reference material

Industries

Related to Astemizole

View every impurity, metabolite and intermediate we list for Astemizole.

Astemizole impurities

Specifications & identifiers

Chemical identifiers
Product name	Astemizole
Catalogue No.	VQ-034785
CAS Number	68844-77-9
IUPAC name	1-[(4-fluorophenyl)methyl]-N-[1-[2-(4-methoxyphenyl)ethyl]piperidin-4-yl]benzimidazol-2-amine
Molecular formula	C₂₈H₃₁FN₄O
Molecular weight	458.6 g/mol
Exact mass	458.2482
Grade	Reference Standard
HSN code	38229090
InChIKey	GXDALQBWZGODGZ-UHFFFAOYSA-N
SMILES	COC1=CC=C(C=C1)CCN2CCC(CC2)NC3=NC4=CC=CC=C4N3CC5=CC=C(C=C5)F
PubChem CID	2247

Physical properties
Physical form	Solid
LogP (XLogP3)	6
H-bond donors / acceptors	1 / 5
TPSA	42.3 Å²
Synonyms	Hismanal, Paralergin, Astemizol, Hestazol, 1-(p-Fluorobenzyl)-2-((1-(p-methoxyphenethyl)-4-piperidyl)amino)benzimidazole, 1-(p-Fluorobenzyl)-2-((1-(2-(p-methoxyphenyl)ethyl)piperid-4-yl)amino)benzimidazole, Alonga, Astemizol, ratiopharm, Astemizol, 1-(p-Fluorobenzyl)-2-[[1-(p-methoxyphenethyl)-4-piperidyl]amino]benzimidazole, Pollon-eze, Laridal, Alermizol

Safety & hazard information (GHS)

Harmful / irritant

Signal word: Warning

Hazard statements

H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation

Precautionary statements: P261, P264, P264 + P265, P271, P280, P302 + P352, P304 + P340, P305 + P351 + P338, P319, P321, P332 + P317, P337 + P317, P362 + P364, P403 + P233, P405, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of Astemizole?

The CAS Registry Number of Astemizole is 68844-77-9. It is also known as Hismanal, Paralergin, Astemizol.

What is the molecular formula and molecular weight of Astemizole?

Astemizole has the molecular formula C28H31FN4O and a molecular weight of 458.6 g/mol. Its IUPAC name is 1-[(4-fluorophenyl)methyl]-N-[1-[2-(4-methoxyphenyl)ethyl]piperidin-4-yl]benzimidazol-2-amine.

What is Astemizole used for?

Astemizole is supplied as a characterised reference material related to Astemizole. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of Astemizole can I order?

We supply Astemizole in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with Astemizole?

Yes. Every lot of Astemizole is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can Astemizole be shipped internationally?

Yes. Astemizole is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.