D-threo-(-)-2-Amino-1-(4-nitrophenyl)-1,3-pro… 716-61-0

About D-threo-(-)-2-Amino-1-(4-nitrophenyl)-1,3-propanediol

D-threo-(-)-2-Amino-1-(4-nitrophenyl)-1,3-propanediol is an impurity of Chloramphenicol carrying the CAS registry number 716-61-0. Its molecular formula is C9H12N2O4 and its molecular weight is 212.2 g/mol. Its systematic (IUPAC) name is (1R,2R)-2-amino-1-(4-nitrophenyl)propane-1,3-diol. Alternative names: Chloramphenicol base and Levoamine.

It is supplied as a solid. Keep the vial tightly closed, protected from light and humidity, at the temperature stated on the Certificate of Analysis. Under GHS it is labelled “Warning”, so handle it with suitable PPE and consult the SDS.

Pharmaceutical QC and development laboratories use this impurity standard of Chloramphenicol to develop and validate HPLC methods, to set specification limits and to document impurity profiles in ANDA and DMF submissions. It is used across pharmaceutical manufacturing and academic and industrial research.

Standard pack sizes are 10 mg, 25 mg, 50 mg and 100 mg, and every batch ships with a Certificate of Analysis (COA) and we export worldwide.

Typical applications

Analytical method development
Method validation (AMV)
QC release testing
ANDA / DMF filings

Industries

Related to Chloramphenicol

View every impurity, metabolite and intermediate we list for Chloramphenicol.

Chloramphenicol impurities

Specifications & identifiers

Chemical identifiers
Product name	D-threo-(-)-2-Amino-1-(4-nitrophenyl)-1,3-propanediol
Catalogue No.	VQ-024925
CAS Number	716-61-0
IUPAC name	(1R,2R)-2-amino-1-(4-nitrophenyl)propane-1,3-diol
Molecular formula	C₉H₁₂N₂O₄
Molecular weight	212.2 g/mol
Exact mass	212.0797
Grade	Reference Standard
HSN code	38229090
InChIKey	OCYJXSUPZMNXEN-RKDXNWHRSA-N
SMILES	C1=CC(=CC=C1[C@H]([C@@H](CO)N)O)[N+](=O)[O-]
PubChem CID	69745

Physical properties
Physical form	Solid
LogP (XLogP3)	-0.7
H-bond donors / acceptors	3 / 5
TPSA	112 Å²
Synonyms	Chloramphenicol base, Levoamine, D-threo-(-)-2-Amino-1-(p-nitrophenyl)-1,3-propanediol, (1R,2R)-(-)-2-Amino-1-(4-nitrophenyl)-1,3-propanediol, (1r,2r)-2-amino-1-(4-nitrophenyl)-1,3-propanediol, (R,R)-2-amino-1-(4-nitrophenyl)propane-1,3-diol, 1,3-Propanediol, 2-amino-1-(p-nitrophenyl)-, D-threo-(-)-, 1,3-Propanediol, 2-amino-1-(4-nitrophenyl)-, (1R,2R)-, D-(-)Threo-2-amino-1-(p-nitrophenyl)propane-1,3-diol

Safety & hazard information (GHS)

Harmful / irritant

Signal word: Warning

Hazard statements

H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation

Precautionary statements: P261, P264, P264 + P265, P270, P271, P280, P301 + P317, P302 + P352, P304 + P340, P305 + P351 + P338, P319, P321, P330, P332 + P317, P337 + P317, P362 + P364, P403 + P233, P405, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of D-threo-(-)-2-Amino-1-(4-nitrophenyl)-1,3-propanediol?

The CAS Registry Number of D-threo-(-)-2-Amino-1-(4-nitrophenyl)-1,3-propanediol is 716-61-0. It is also known as Chloramphenicol base, Levoamine, D-threo-(-)-2-Amino-1-(p-nitrophenyl)-1,3-propanediol.

What is the molecular formula and molecular weight of D-threo-(-)-2-Amino-1-(4-nitrophenyl)-1,3-propanediol?

D-threo-(-)-2-Amino-1-(4-nitrophenyl)-1,3-propanediol has the molecular formula C9H12N2O4 and a molecular weight of 212.2 g/mol. Its IUPAC name is (1R,2R)-2-amino-1-(4-nitrophenyl)propane-1,3-diol.

What is D-threo-(-)-2-Amino-1-(4-nitrophenyl)-1,3-propanediol used for?

D-threo-(-)-2-Amino-1-(4-nitrophenyl)-1,3-propanediol is supplied as a characterised reference material related to Chloramphenicol. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of D-threo-(-)-2-Amino-1-(4-nitrophenyl)-1,3-propanediol can I order?

We supply D-threo-(-)-2-Amino-1-(4-nitrophenyl)-1,3-propanediol in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with D-threo-(-)-2-Amino-1-(4-nitrophenyl)-1,3-propanediol?

Yes. Every lot of D-threo-(-)-2-Amino-1-(4-nitrophenyl)-1,3-propanediol is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can D-threo-(-)-2-Amino-1-(4-nitrophenyl)-1,3-propanediol be shipped internationally?

Yes. D-threo-(-)-2-Amino-1-(4-nitrophenyl)-1,3-propanediol is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.