O-Acetyl-L-mandelic Acid

About O-Acetyl-L-mandelic Acid

O-Acetyl-L-mandelic Acid is a process intermediate or related compound of N methylpyrrolidone carrying the CAS registry number 7322-88-5. Formula C10H10O4, molecular weight 194.18 g/mol. Systematically, it is named (2S)-2-acetyloxy-2-phenylacetic acid. Alternative names: (S)-2-Acetoxy-2-phenylacetic Acid and (S)-O-Acetylmandelic Acid.

It is supplied as a solid. Reference materials should be stored sealed and away from light and moisture, as specified on the accompanying COA. The GHS classification uses the signal word “Warning”, so appropriate gloves, eye protection and ventilation are recommended.

Process chemists and analysts use it when developing synthetic routes to N methylpyrrolidone, tracking process-related impurities and validating analytical methods. Typical end-use sectors are pharmaceutical manufacturing and academic and industrial research.

Available in 10 mg, 25 mg, 50 mg and 100 mg packs, O-Acetyl-L-mandelic Acid is dispatched with a Certificate of Analysis (COA) to destinations worldwide.

Typical applications

API route development
Impurity fate & purge studies
Analytical method development

Industries

Related to N methylpyrrolidone

View every impurity, metabolite and intermediate we list for N methylpyrrolidone.

N methylpyrrolidone impurities

Specifications & identifiers

Chemical identifiers
Product name	O-Acetyl-L-mandelic Acid
Catalogue No.	VQ-049414
CAS Number	7322-88-5
IUPAC name	(2S)-2-acetyloxy-2-phenylacetic acid
Molecular formula	C₁₀H₁₀O₄
Molecular weight	194.18 g/mol
Exact mass	194.0579
InChIKey	OBCUSTCTKLTMBX-VIFPVBQESA-N
SMILES	CC(=O)O[C@@H](C1=CC=CC=C1)C(=O)O
PubChem CID	6923379

Physical properties
Physical form	Solid
LogP (XLogP3)	1.4
H-bond donors / acceptors	1 / 4
TPSA	63.6 Å²
Synonyms	(S)-2-Acetoxy-2-phenylacetic Acid, (S)-O-Acetylmandelic Acid, (S)-(+)-O-Acetylmandelic acid, acetyl mandelic acid, (S)-(+)-alpha-Acetoxyphenylacetic acid, (+)-acetylmandelic acid, S-Acetylmandelic Acid, Acetylmandelic acid, (+)-, (S)-(+)-O-Acetyl-L-mandelic acid, (+)-o-acetylmandelic acid, (S)-alpha-Acetoxyphenylacetic acid

Safety & hazard information (GHS)

Harmful / irritant

Signal word: Warning

Hazard statements

H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation

Precautionary statements: P261, P264, P264 + P265, P270, P271, P280, P301 + P317, P302 + P352, P304 + P340, P305 + P351 + P338, P319, P321, P330, P332 + P317, P337 + P317, P362 + P364, P403 + P233, P405, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of O-Acetyl-L-mandelic Acid?

The CAS Registry Number of O-Acetyl-L-mandelic Acid is 7322-88-5. It is also known as (S)-2-Acetoxy-2-phenylacetic Acid, (S)-O-Acetylmandelic Acid, (S)-(+)-O-Acetylmandelic acid.

What is the molecular formula and molecular weight of O-Acetyl-L-mandelic Acid?

O-Acetyl-L-mandelic Acid has the molecular formula C10H10O4 and a molecular weight of 194.18 g/mol. Its IUPAC name is (2S)-2-acetyloxy-2-phenylacetic acid.

What is O-Acetyl-L-mandelic Acid used for?

O-Acetyl-L-mandelic Acid is supplied as a characterised reference material related to N methylpyrrolidone. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of O-Acetyl-L-mandelic Acid can I order?

We supply O-Acetyl-L-mandelic Acid, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with O-Acetyl-L-mandelic Acid?

Yes. Every lot of O-Acetyl-L-mandelic Acid is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can O-Acetyl-L-mandelic Acid be shipped internationally?

Yes. O-Acetyl-L-mandelic Acid is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.