Z-Benfotiamine

About Z-Benfotiamine

Z-Benfotiamine is an impurity of Benfotiamine carrying the CAS registry number 775256-41-2. The compound has the formula C19H23N4O6PS, corresponding to a molecular weight of 466.4 g/mol. It is also known as benfotiamine or Benphothiamine.

It is supplied as a solid. Keep the vial tightly closed, protected from light and humidity, at the temperature stated on the Certificate of Analysis. It carries the GHS signal word “Warning” with 3 hazard statements. Review the Safety Data Sheet before use.

Pharmaceutical QC and development laboratories use this impurity standard of Benfotiamine to develop and validate HPLC methods, to set specification limits and to document impurity profiles in ANDA and DMF submissions. Our customers for this product work in pharmaceutical manufacturing and academic and industrial research.

We offer Z-Benfotiamine in 10 mg, 25 mg, 50 mg and 100 mg packs with a batch-specific COA, and ship to customers worldwide.

Typical applications

Analytical method development
Method validation (AMV)
QC release testing
ANDA / DMF filings

Industries

Related to Benfotiamine

View every impurity, metabolite and intermediate we list for Benfotiamine.

Benfotiamine impurities

Specifications & identifiers

Chemical identifiers
Product name	Z-Benfotiamine
Catalogue No.	VQ-034914
CAS Number	775256-41-2
IUPAC name	S-[(Z)-2-[(4-amino-2-methylpyrimidin-5-yl)methyl-formylamino]-5-phosphonooxypent-2-en-3-yl] benzenecarbothioate
Molecular formula	C₁₉H₂₃N₄O₆PS
Molecular weight	466.4 g/mol
Exact mass	466.1076
Grade	Reference Standard
HSN code	38229090
InChIKey	BTNNPSLJPBRMLZ-LGMDPLHJSA-N
SMILES	CC1=NC=C(C(=N1)N)CN(C=O)/C(=C(/CCOP(=O)(O)O)\SC(=O)C2=CC=CC=C2)/C
PubChem CID	3032771

Physical properties
Physical form	Solid
LogP (XLogP3)	0.5
H-bond donors / acceptors	3 / 10
TPSA	181 Å²
Synonyms	benfotiamine, Benphothiamine, Benzoylthiamine monophosphate, benfothiamine, S-Benzoylthiamine monophosphate, Biotamin, S-Benzoylthiamine O-monophosphate, Benzoylthiamine O-monophosphate, BTMP-benfo, 22457-89-2 (free acid)

Safety & hazard information (GHS)

Harmful / irritant

Signal word: Warning

Hazard statements

H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation

Precautionary statements: P261, P264, P264 + P265, P271, P280, P302 + P352, P304 + P340, P305 + P351 + P338, P319, P321, P332 + P317, P337 + P317, P362 + P364, P403 + P233, P405, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of Z-Benfotiamine?

The CAS Registry Number of Z-Benfotiamine is 775256-41-2. It is also known as benfotiamine, Benphothiamine, Benzoylthiamine monophosphate.

What is the molecular formula and molecular weight of Z-Benfotiamine?

Z-Benfotiamine has the molecular formula C19H23N4O6PS and a molecular weight of 466.4 g/mol. Its IUPAC name is S-[(Z)-2-[(4-amino-2-methylpyrimidin-5-yl)methyl-formylamino]-5-phosphonooxypent-2-en-3-yl] benzenecarbothioate.

What is Z-Benfotiamine used for?

Z-Benfotiamine is supplied as a characterised reference material related to Benfotiamine. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of Z-Benfotiamine can I order?

We supply Z-Benfotiamine in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with Z-Benfotiamine?

Yes. Every lot of Z-Benfotiamine is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can Z-Benfotiamine be shipped internationally?

Yes. Z-Benfotiamine is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.