N-Nitroso Phenylephrine

Name: N-Nitroso Phenylephrine
Brand: Vaqora Chemicals
SKU: VQ-023694

About N-Nitroso Phenylephrine

Vaqora Chemicals supplies N-Nitroso Phenylephrine, a nitrosamine impurity of Phenylephrine registered under CAS number 78658-64-7. The compound has the formula C9H12N2O3, corresponding to a molecular weight of 196.2 g/mol. Its systematic (IUPAC) name is N-[(2R)-2-hydroxy-2-(3-hydroxyphenyl)ethyl]-N-methylnitrous amide. It is also known as N-Nitroso Phenylephrine (Mixture of Isomers).

The product is provided as a solid. Store the standard in its sealed vial, protected from light and moisture, and follow the storage condition printed on the COA. Under GHS it is labelled “Warning”, so handle it with suitable PPE and consult the SDS.

Laboratories use this nitrosamine standard to develop and validate highly sensitive LC-MS/MS methods, to confirm limits of detection and to document nitrosamine risk assessments in regulatory submissions. It is used across pharmaceutical manufacturing and academic and industrial research.

Available in 10 mg, 25 mg, 50 mg and 100 mg packs, N-Nitroso Phenylephrine is dispatched with a Certificate of Analysis (COA) to destinations worldwide.

Typical applications

Nitrosamine risk assessment
Trace LC-MS/MS quantitation
Method validation (AMV)
Regulatory submissions

Industries

Related to Phenylephrine

View every impurity, metabolite and intermediate we list for Phenylephrine.

Phenylephrine impurities

Specifications & identifiers

Chemical identifiers
Product name	N-Nitroso Phenylephrine
Catalogue No.	VQ-023694
CAS Number	78658-64-7
IUPAC name	N-[(2R)-2-hydroxy-2-(3-hydroxyphenyl)ethyl]-N-methylnitrous amide
Molecular formula	C₉H₁₂N₂O₃
Molecular weight	196.2 g/mol
Exact mass	196.0848
Grade	Reference Standard
HSN code	38229090
InChIKey	JKVBNSISJSOSBA-VIFPVBQESA-N
SMILES	CN(C[C@@H](C1=CC(=CC=C1)O)O)N=O
PubChem CID	165729371

Physical properties
Physical form	Solid
LogP (XLogP3)	0.7
H-bond donors / acceptors	2 / 5
TPSA	73.1 Å²

Safety & hazard information (GHS)

Harmful / irritant

Signal word: Warning

Hazard statements

H302Harmful if swallowed
H317May cause an allergic skin reaction

Precautionary statements: P261, P264, P270, P272, P280, P301 + P317, P302 + P352, P321, P330, P333 + P317, P362 + P364, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of N-Nitroso Phenylephrine?

The CAS Registry Number of N-Nitroso Phenylephrine is 78658-64-7. It is also known as N-Nitroso Phenylephrine (Mixture of Isomers), 3-[(1R)-1-hydroxy-2-[methyl(nitroso)amino]ethyl]phenol, (R)-N-(2-Hydroxy-2-(3-hydroxyphenyl)ethyl)-N-methylnitrous amide.

What is the molecular formula and molecular weight of N-Nitroso Phenylephrine?

N-Nitroso Phenylephrine has the molecular formula C9H12N2O3 and a molecular weight of 196.2 g/mol. Its IUPAC name is N-[(2R)-2-hydroxy-2-(3-hydroxyphenyl)ethyl]-N-methylnitrous amide.

What is N-Nitroso Phenylephrine used for?

N-Nitroso Phenylephrine is supplied as a characterised reference material related to Phenylephrine. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of N-Nitroso Phenylephrine can I order?

We supply N-Nitroso Phenylephrine in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with N-Nitroso Phenylephrine?

Yes. Every lot of N-Nitroso Phenylephrine is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can N-Nitroso Phenylephrine be shipped internationally?

Yes. N-Nitroso Phenylephrine is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.