α-Dihydroartemisinin

Name: α-Dihydroartemisinin
Brand: Vaqora Chemicals
SKU: VQ-029221

About α-Dihydroartemisinin

Listed under CAS 81496-81-3, α-Dihydroartemisinin is an impurity of Artemisinin available from Vaqora Chemicals. The compound has the formula C15H24O5, corresponding to a molecular weight of 284.35 g/mol. Systematically, it is named (1R,4S,5R,8S,9R,10R,12R,13R)-1,5,9-trimethyl-11,14,15,16-tetraoxatetracyclo[10.3.1.04,13.08,13]hexadecan-10-ol. It is also known as alpha-Dihydroartemisinin or Dihydroartemisinin (DHA).

The product is provided as a solid. Reference materials should be stored sealed and away from light and moisture, as specified on the accompanying COA. The GHS classification uses the signal word “Danger”, so appropriate gloves, eye protection and ventilation are recommended.

As a characterised impurity of Artemisinin, it is used for analytical method development, method validation (AMV) and routine quality-control testing, and it supports ANDA and DMF regulatory filings. Our customers for this product work in pharmaceutical manufacturing and academic and industrial research.

We offer α-Dihydroartemisinin in 10 mg, 25 mg, 50 mg and 100 mg packs with a batch-specific COA, and ship to customers worldwide.

Typical applications

Analytical method development
Method validation (AMV)
QC release testing
ANDA / DMF filings

Industries

Related to Artemisinin

View every impurity, metabolite and intermediate we list for Artemisinin.

Artemisinin impurities

Specifications & identifiers

Chemical identifiers
Product name	α-Dihydroartemisinin
Catalogue No.	VQ-029221
CAS Number	81496-81-3
IUPAC name	(1R,4S,5R,8S,9R,10R,12R,13R)-1,5,9-trimethyl-11,14,15,16-tetraoxatetracyclo[10.3.1.04,13.08,13]hexadecan-10-ol
Molecular formula	C₁₅H₂₄O₅
Molecular weight	284.35 g/mol
Exact mass	284.1624
Grade	Reference Standard
HSN code	38229090
InChIKey	BJDCWCLMFKKGEE-KDTBHNEXSA-N
SMILES	C[C@@H]1CC[C@H]2[C@H]([C@@H](O[C@H]3[C@@]24[C@H]1CC[C@](O3)(OO4)C)O)C
PubChem CID	11358077

Physical properties
Physical form	Solid
LogP (XLogP3)	2.5
H-bond donors / acceptors	1 / 5
TPSA	57.2 Å²
Synonyms	alpha-Dihydroartemisinin, Dihydroartemisinin (DHA), 3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-ol, cent-Dihydroqinghaosu, cent-Dihydroartemisinin

Safety & hazard information (GHS)

Flammable

Environmental hazard

Signal word: Danger

Hazard statements

H242Heating may cause a fire
H411Toxic to aquatic life with long lasting effects

Precautionary statements: P210, P234, P235, P240, P273, P280, P370 + P378, P391, P403, P410, P411, P420, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of α-Dihydroartemisinin?

The CAS Registry Number of α-Dihydroartemisinin is 81496-81-3. It is also known as alpha-Dihydroartemisinin, Dihydroartemisinin (DHA), 3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-ol.

What is the molecular formula and molecular weight of α-Dihydroartemisinin?

α-Dihydroartemisinin has the molecular formula C15H24O5 and a molecular weight of 284.35 g/mol. Its IUPAC name is (1R,4S,5R,8S,9R,10R,12R,13R)-1,5,9-trimethyl-11,14,15,16-tetraoxatetracyclo[10.3.1.04,13.08,13]hexadecan-10-ol.

What is α-Dihydroartemisinin used for?

α-Dihydroartemisinin is supplied as a characterised reference material related to Artemisinin. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of α-Dihydroartemisinin can I order?

We supply α-Dihydroartemisinin in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with α-Dihydroartemisinin?

Yes. Every lot of α-Dihydroartemisinin is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can α-Dihydroartemisinin be shipped internationally?

Yes. α-Dihydroartemisinin is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.