1-Hydroxy-2(1H)-pyridinone

Name: 1-Hydroxy-2(1H)-pyridinone
Brand: Vaqora Chemicals
SKU: VQ-031000

About 1-Hydroxy-2(1H)-pyridinone

Listed under CAS 822-89-9, 1-Hydroxy-2(1H)-pyridinone is a metabolite or degradation product of Glecaprevir available from Vaqora Chemicals. The compound has the formula C5H5NO2, corresponding to a molecular weight of 111.1 g/mol. Systematically, it is named 1-hydroxypyridin-2-one. Common synonyms include 2-Pyridinol-1-oxide and 2-Hydroxypyridine 1-oxide.

It is supplied as a solid. Keep the vial tightly closed, protected from light and humidity, at the temperature stated on the Certificate of Analysis. It carries the GHS signal word “Warning” with 3 hazard statements. Review the Safety Data Sheet before use.

It is used in metabolite identification, stability-indicating method development and impurity profiling of Glecaprevir, as well as in QC testing and ANDA/DMF documentation. It is used across pharmaceutical manufacturing and academic and industrial research.

Available in 10 mg, 25 mg, 50 mg and 100 mg packs, 1-Hydroxy-2(1H)-pyridinone is dispatched with a Certificate of Analysis (COA) to destinations worldwide.

Typical applications

Metabolite identification
Stability-indicating methods
Impurity profiling

Industries

Related to Glecaprevir

View every impurity, metabolite and intermediate we list for Glecaprevir.

Glecaprevir impurities

Specifications & identifiers

Chemical identifiers
Product name	1-Hydroxy-2(1H)-pyridinone
Catalogue No.	VQ-031000
CAS Number	822-89-9
IUPAC name	1-hydroxypyridin-2-one
Molecular formula	C₅H₅NO₂
Molecular weight	111.1 g/mol
Exact mass	111.032
Grade	Reference Standard
HSN code	38229090
InChIKey	SNUSZUYTMHKCPM-UHFFFAOYSA-N
SMILES	C1=CC(=O)N(C=C1)O
PubChem CID	69975

Physical properties
Physical form	Solid
LogP (XLogP3)	-0.7
H-bond donors / acceptors	1 / 2
TPSA	40.5 Å²
Synonyms	2-Pyridinol-1-oxide, 2-Hydroxypyridine 1-oxide, Hydroxypyridinone, 1-Hydroxy-2-pyridone, 2-Pyridinol, 1-oxide, 2(1H)-Pyridinone, 1-hydroxy-, Hydroxyl-2-pyridone, N-hydroxy-2-pyridone, N-Hydroxyl-2-pyridone, 1-hydroxy-2(1H)-pyridone, 2-Pyridinol, N-oxide, 1,2-HOPO

Safety & hazard information (GHS)

Harmful / irritant

Signal word: Warning

Hazard statements

H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation

Precautionary statements: P261, P264, P264 + P265, P271, P280, P302 + P352, P304 + P340, P305 + P351 + P338, P319, P321, P332 + P317, P337 + P317, P362 + P364, P403 + P233, P405, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of 1-Hydroxy-2(1H)-pyridinone?

The CAS Registry Number of 1-Hydroxy-2(1H)-pyridinone is 822-89-9. It is also known as 2-Pyridinol-1-oxide, 2-Hydroxypyridine 1-oxide, Hydroxypyridinone.

What is the molecular formula and molecular weight of 1-Hydroxy-2(1H)-pyridinone?

1-Hydroxy-2(1H)-pyridinone has the molecular formula C5H5NO2 and a molecular weight of 111.1 g/mol. Its IUPAC name is 1-hydroxypyridin-2-one.

What is 1-Hydroxy-2(1H)-pyridinone used for?

1-Hydroxy-2(1H)-pyridinone is supplied as a characterised reference material related to Glecaprevir. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of 1-Hydroxy-2(1H)-pyridinone can I order?

We supply 1-Hydroxy-2(1H)-pyridinone in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with 1-Hydroxy-2(1H)-pyridinone?

Yes. Every lot of 1-Hydroxy-2(1H)-pyridinone is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can 1-Hydroxy-2(1H)-pyridinone be shipped internationally?

Yes. 1-Hydroxy-2(1H)-pyridinone is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.