Propranolol Impurity B

About Propranolol Impurity B

Propranolol Impurity B is an impurity of Propranolol carrying the CAS registry number 83314-78-7. Its molecular formula is C29H33NO4 and its molecular weight is 459.6 g/mol. Systematically, it is named 1-[(2-hydroxy-3-naphthalen-1-yloxypropyl)-propan-2-ylamino]-3-naphthalen-1-yloxypropan-2-ol. Alternative names: Tertiary amine derivative and Propranolol hydrochloride impurity B.

It is supplied as a solid. Keep the vial tightly closed, protected from light and humidity, at the temperature stated on the Certificate of Analysis. It carries the GHS signal word “Warning” with 3 hazard statements. Review the Safety Data Sheet before use.

Pharmaceutical QC and development laboratories use this impurity standard of Propranolol to develop and validate HPLC methods, to set specification limits and to document impurity profiles in ANDA and DMF submissions. Our customers for this product work in pharmaceutical manufacturing and academic and industrial research.

Available in 10 mg, 25 mg, 50 mg and 100 mg packs, Propranolol Impurity B is dispatched with a Certificate of Analysis (COA) to destinations worldwide.

Typical applications

Analytical method development
Method validation (AMV)
QC release testing
ANDA / DMF filings

Industries

Related to Propranolol

View every impurity, metabolite and intermediate we list for Propranolol.

Propranolol impurities

Specifications & identifiers

Chemical identifiers
Product name	Propranolol Impurity B
Catalogue No.	VQ-005652
CAS Number	83314-78-7
IUPAC name	1-[(2-hydroxy-3-naphthalen-1-yloxypropyl)-propan-2-ylamino]-3-naphthalen-1-yloxypropan-2-ol
Molecular formula	C₂₉H₃₃NO₄
Molecular weight	459.6 g/mol
Exact mass	459.241
Grade	Reference Standard
HSN code	38229090
InChIKey	MKZHJJQCUIZEDE-UHFFFAOYSA-N
SMILES	CC(C)N(CC(COC1=CC=CC2=CC=CC=C21)O)CC(COC3=CC=CC4=CC=CC=C43)O
PubChem CID	13357172

Physical properties
Physical form	Solid
LogP (XLogP3)	5.7
H-bond donors / acceptors	2 / 5
TPSA	62.2 Å²
Synonyms	3,3'-(isopropylazanediyl)bis(1-(naphthalen-1-yloxy)propan-2-ol), Tertiary amine derivative, 1,1-((1-Methylethyl)imino)bis(3-(naphthalen-1-yloxy)propan-2-ol), 2-Propanol, 1,1'-((1-methylethyl)imino)bis(3-(1-naphthalenyloxy)-, 2-Propanol, 1,1'-[(1-methylethyl)imino]bis[3-(1-naphthalenyloxy)-, Propranolol hydrochloride impurity B, Propranolol EP Impurity B, 1,1'-[(1-Methylethyl)imino]bis[3-(1-naphthalenyloxy)-2-propanol, 1,1'-[(1-Methylethyl)imino]bis[3-(1-naphthalenyloxy)-2-propanol], Propranolol Impurity-B, 1,1'-[(1-methylethyl)imino]bis[3-(naphthalen-1yloxy)propan-2-ol], 1,1'-[(Propan-2-yl)azanediyl]bis{3-[(naphthalen-1-yl)oxy]propan-2-ol}

Safety & hazard information (GHS)

Harmful / irritant

Health hazard

Environmental hazard

Signal word: Warning

Hazard statements

H302Harmful if swallowed
H341Suspected of causing genetic defects
H410Very toxic to aquatic life with long lasting effects

Precautionary statements: P203, P264, P270, P273, P280, P301 + P317, P318, P330, P391, P405, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of Propranolol Impurity B?

The CAS Registry Number of Propranolol Impurity B is 83314-78-7. It is also known as 3,3'-(isopropylazanediyl)bis(1-(naphthalen-1-yloxy)propan-2-ol), Tertiary amine derivative, 1,1-((1-Methylethyl)imino)bis(3-(naphthalen-1-yloxy)propan-2-ol).

What is the molecular formula and molecular weight of Propranolol Impurity B?

Propranolol Impurity B has the molecular formula C29H33NO4 and a molecular weight of 459.6 g/mol. Its IUPAC name is 1-[(2-hydroxy-3-naphthalen-1-yloxypropyl)-propan-2-ylamino]-3-naphthalen-1-yloxypropan-2-ol.

What is Propranolol Impurity B used for?

Propranolol Impurity B is supplied as a characterised reference material related to Propranolol. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of Propranolol Impurity B can I order?

We supply Propranolol Impurity B in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with Propranolol Impurity B?

Yes. Every lot of Propranolol Impurity B is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can Propranolol Impurity B be shipped internationally?

Yes. Propranolol Impurity B is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.