14-Hydroxynormorphinone

Name: 14-Hydroxynormorphinone
Brand: Vaqora Chemicals
SKU: VQ-049090

About 14-Hydroxynormorphinone

14-Hydroxynormorphinone (CAS 84116-46-1) is an impurity of Methylnaltrexone offered by Vaqora Chemicals. With the molecular formula C16H15NO4, it has a molar mass of 285.29 g/mol. Systematically, it is named (4R,4aS,7aR,12bS)-4a,9-dihydroxy-1,2,3,4,7a,13-hexahydro-4,12-methanobenzofuro[3,2-e]isoquinolin-7-one.

It is supplied as a solid. Reference materials should be stored sealed and away from light and moisture, as specified on the accompanying COA. Under GHS it is labelled “Danger”, so handle it with suitable PPE and consult the SDS.

This Methylnaltrexone impurity supports analytical method development and validation (AMV), batch release testing and the impurity sections of ANDA and DMF filings. Our customers for this product work in pharmaceutical manufacturing and academic and industrial research.

Vaqora Chemicals supplies 14-Hydroxynormorphinone in 10 mg, 25 mg, 50 mg and 100 mg packs, each shipped with a Certificate of Analysis (COA), and exports worldwide.

Typical applications

Analytical method development
Method validation (AMV)
QC release testing
ANDA / DMF filings

Industries

Related to Methylnaltrexone

View every impurity, metabolite and intermediate we list for Methylnaltrexone.

Methylnaltrexone impurities

Specifications & identifiers

Chemical identifiers
Product name	14-Hydroxynormorphinone
Catalogue No.	VQ-049090
CAS Number	84116-46-1
IUPAC name	(4R,4aS,7aR,12bS)-4a,9-dihydroxy-1,2,3,4,7a,13-hexahydro-4,12-methanobenzofuro[3,2-e]isoquinolin-7-one
Molecular formula	C₁₆H₁₅NO₄
Molecular weight	285.29 g/mol
Exact mass	285.1001
Grade	Reference Standard
HSN code	38229090
InChIKey	WJZVCRUPHQAKSZ-IPOQPSJVSA-N
SMILES	C1CN[C@@H]2CC3=C4[C@@]15[C@]2(C=CC(=O)[C@@H]5OC4=C(C=C3)O)O
PubChem CID	15605738

Physical properties
Physical form	Solid
LogP (XLogP3)	0.3
H-bond donors / acceptors	3 / 5
TPSA	78.8 Å²

Safety & hazard information (GHS)

Harmful / irritant

Health hazard

Signal word: Danger

Hazard statements

H302Harmful if swallowed
H317May cause an allergic skin reaction
H332Harmful if inhaled
H334May cause allergy or asthma symptoms or breathing difficulties if inhaled

Precautionary statements: P233, P260, P261, P264, P270, P271, P272, P280, P284, P301 + P317, P302 + P352, P304 + P340, P317, P321, P330, P333 + P317, P342 + P316, P362 + P364, P403, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of 14-Hydroxynormorphinone?

The CAS Registry Number of 14-Hydroxynormorphinone is 84116-46-1. It is also known as (5alpha)-7,8-Didehydro-4,5-epoxy-3,14-dihydroxymorphinan-6-one, 3,14-Dihydroxy-5alpha-7,8-didehydro-4,5-epoxymorphinan-6-one.

What is the molecular formula and molecular weight of 14-Hydroxynormorphinone?

14-Hydroxynormorphinone has the molecular formula C16H15NO4 and a molecular weight of 285.29 g/mol. Its IUPAC name is (4R,4aS,7aR,12bS)-4a,9-dihydroxy-1,2,3,4,7a,13-hexahydro-4,12-methanobenzofuro[3,2-e]isoquinolin-7-one.

What is 14-Hydroxynormorphinone used for?

14-Hydroxynormorphinone is supplied as a characterised reference material related to Methylnaltrexone. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of 14-Hydroxynormorphinone can I order?

We supply 14-Hydroxynormorphinone in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with 14-Hydroxynormorphinone?

Yes. Every lot of 14-Hydroxynormorphinone is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can 14-Hydroxynormorphinone be shipped internationally?

Yes. 14-Hydroxynormorphinone is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.