Tamatinib

About Tamatinib

Tamatinib is an impurity of Fostamatinib carrying the CAS registry number 841290-80-0. Its molecular formula is C22H23FN6O5 and its molecular weight is 470.5 g/mol. Systematically, it is named 6-[[5-fluoro-2-(3,4,5-trimethoxyanilino)pyrimidin-4-yl]amino]-2,2-dimethyl-4H-pyrido[3,2-b][1,4]oxazin-3-one. It is also known as R406 free base or R406 (free base).

The product is provided as a solid. Store the standard in its sealed vial, protected from light and moisture, and follow the storage condition printed on the COA. Under GHS it is labelled “Danger”, so handle it with suitable PPE and consult the SDS.

As a characterised impurity of Fostamatinib, it is used for analytical method development, method validation (AMV) and routine quality-control testing, and it supports ANDA and DMF regulatory filings. Our customers for this product work in pharmaceutical manufacturing and academic and industrial research.

Standard pack sizes are 10 mg, 25 mg, 50 mg and 100 mg, and every batch ships with a Certificate of Analysis (COA) and we export worldwide.

Typical applications

Analytical method development
Method validation (AMV)
QC release testing
ANDA / DMF filings

Industries

Related to Fostamatinib

View every impurity, metabolite and intermediate we list for Fostamatinib.

Fostamatinib impurities

Specifications & identifiers

Chemical identifiers
Product name	Tamatinib
Catalogue No.	VQ-025926
CAS Number	841290-80-0
IUPAC name	6-[[5-fluoro-2-(3,4,5-trimethoxyanilino)pyrimidin-4-yl]amino]-2,2-dimethyl-4H-pyrido[3,2-b][1,4]oxazin-3-one
Molecular formula	C₂₂H₂₃FN₆O₅
Molecular weight	470.5 g/mol
Exact mass	470.1714
Grade	Reference Standard
HSN code	38229090
InChIKey	NHHQJBCNYHBUSI-UHFFFAOYSA-N
SMILES	CC1(C(=O)NC2=C(O1)C=CC(=N2)NC3=NC(=NC=C3F)NC4=CC(=C(C(=C4)OC)OC)OC)C
PubChem CID	11213558

Physical properties
Physical form	Solid
LogP (XLogP3)	3.1
H-bond donors / acceptors	3 / 11
TPSA	129 Å²
Synonyms	R406 free base, R406 (free base), Tamatinib free base, R406(free base), 3fqs, 3piy, Kinome_1211, EX-A103

Safety & hazard information (GHS)

Toxic

Health hazard

Signal word: Danger

Hazard statements

H301Toxic if swallowed
H361Suspected of damaging fertility or the unborn child

Precautionary statements: P203, P264, P270, P280, P301 + P316, P318, P321, P330, P405, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of Tamatinib?

The CAS Registry Number of Tamatinib is 841290-80-0. It is also known as R406 free base, R406 (free base), Tamatinib free base.

What is the molecular formula and molecular weight of Tamatinib?

Tamatinib has the molecular formula C22H23FN6O5 and a molecular weight of 470.5 g/mol. Its IUPAC name is 6-[[5-fluoro-2-(3,4,5-trimethoxyanilino)pyrimidin-4-yl]amino]-2,2-dimethyl-4H-pyrido[3,2-b][1,4]oxazin-3-one.

What is Tamatinib used for?

Tamatinib is supplied as a characterised reference material related to Fostamatinib. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of Tamatinib can I order?

We supply Tamatinib in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with Tamatinib?

Yes. Every lot of Tamatinib is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can Tamatinib be shipped internationally?

Yes. Tamatinib is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.