N-Boc-4-Oxo-L-proline

About N-Boc-4-Oxo-L-proline

N-Boc-4-Oxo-L-proline is an impurity of Velpatasvir carrying the CAS registry number 84348-37-8. The compound has the formula C10H15NO5, corresponding to a molecular weight of 229.23 g/mol. The IUPAC name is (2S)-1-[(2-methylpropan-2-yl)oxycarbonyl]-4-oxopyrrolidine-2-carboxylic acid. Alternative names: Boc-4-oxo-Pro-OH and 1-(tert-Butoxycarbonyl)-4-oxo-L-proline.

It is supplied as a solid. Store the standard in its sealed vial, protected from light and moisture, and follow the storage condition printed on the COA. The GHS classification uses the signal word “Warning”, so appropriate gloves, eye protection and ventilation are recommended.

As a characterised impurity of Velpatasvir, it is used for analytical method development, method validation (AMV) and routine quality-control testing, and it supports ANDA and DMF regulatory filings. Typical end-use sectors are pharmaceutical manufacturing and academic and industrial research.

We offer N-Boc-4-Oxo-L-proline in 10 mg, 25 mg, 50 mg and 100 mg packs with a batch-specific COA, and ship to customers worldwide.

Typical applications

Analytical method development
Method validation (AMV)
QC release testing
ANDA / DMF filings

Industries

Related to Velpatasvir

View every impurity, metabolite and intermediate we list for Velpatasvir.

Velpatasvir impurities

Specifications & identifiers

Chemical identifiers
Product name	N-Boc-4-Oxo-L-proline
Catalogue No.	VQ-034096
CAS Number	84348-37-8
IUPAC name	(2S)-1-[(2-methylpropan-2-yl)oxycarbonyl]-4-oxopyrrolidine-2-carboxylic acid
Molecular formula	C₁₀H₁₅NO₅
Molecular weight	229.23 g/mol
Exact mass	229.095
Grade	Reference Standard
HSN code	38229090
InChIKey	CKYGSXRXTIKGAJ-ZETCQYMHSA-N
SMILES	CC(C)(C)OC(=O)N1CC(=O)C[C@H]1C(=O)O
PubChem CID	11593804

Physical properties
Physical form	Solid
LogP (XLogP3)	0.3
H-bond donors / acceptors	1 / 5
TPSA	83.9 Å²
Synonyms	(2S)-1-(tert-butoxycarbonyl)-4-oxopyrrolidine-2-carboxylic acid, 1-(1,1-Dimethylethyl) (2S)-4-oxo-1,2-pyrrolidinedicarboxylate, Boc-4-oxo-Pro-OH, (S)-1-(Tert-Butoxycarbonyl)-4-oxopyrrolidine-2-carboxylic acid, (2S)-1-tert-butoxycarbonyl-4-oxo-pyrrolidine-2-carboxylic acid, (2S)-1-[(tert-butoxy)carbonyl]-4-oxopyrrolidine-2-carboxylic acid, 1-(tert-Butoxycarbonyl)-4-oxo-L-proline, N-t-boc-4-oxo-L-proline, (2S)-1-(tert-butoxycarbonyl)-4-oxo-2-pyrrolidinecarboxylic acid, 1-(tert-butoxycarbonyl)-4-oxoproline, N-tert-Boc-4-oxo-L-proline, Boc-L-Pro(4-oxo)

Safety & hazard information (GHS)

Harmful / irritant

Signal word: Warning

Hazard statements

H302Harmful if swallowed
H319Causes serious eye irritation

Precautionary statements: P264, P264 + P265, P270, P280, P301 + P317, P305 + P351 + P338, P330, P337 + P317, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of N-Boc-4-Oxo-L-proline?

The CAS Registry Number of N-Boc-4-Oxo-L-proline is 84348-37-8. It is also known as (2S)-1-(tert-butoxycarbonyl)-4-oxopyrrolidine-2-carboxylic acid, 1-(1,1-Dimethylethyl) (2S)-4-oxo-1,2-pyrrolidinedicarboxylate, Boc-4-oxo-Pro-OH.

What is the molecular formula and molecular weight of N-Boc-4-Oxo-L-proline?

N-Boc-4-Oxo-L-proline has the molecular formula C10H15NO5 and a molecular weight of 229.23 g/mol. Its IUPAC name is (2S)-1-[(2-methylpropan-2-yl)oxycarbonyl]-4-oxopyrrolidine-2-carboxylic acid.

What is N-Boc-4-Oxo-L-proline used for?

N-Boc-4-Oxo-L-proline is supplied as a characterised reference material related to Velpatasvir. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of N-Boc-4-Oxo-L-proline can I order?

We supply N-Boc-4-Oxo-L-proline in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with N-Boc-4-Oxo-L-proline?

Yes. Every lot of N-Boc-4-Oxo-L-proline is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can N-Boc-4-Oxo-L-proline be shipped internationally?

Yes. N-Boc-4-Oxo-L-proline is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.