Raloxifene

About Raloxifene

Raloxifene is a high-purity reference standard of Raloxifene carrying the CAS registry number 84449-90-1. Formula C28H27NO4S, molecular weight 473.6 g/mol. Systematically, it is named [6-hydroxy-2-(4-hydroxyphenyl)-1-benzothiophen-3-yl]-[4-(2-piperidin-1-ylethoxy)phenyl]methanone. It is also known as Keoxifene or Raloxiphene.

It is supplied as a solid. Keep the vial tightly closed, protected from light and humidity, at the temperature stated on the Certificate of Analysis. The GHS classification uses the signal word “Danger”, so appropriate gloves, eye protection and ventilation are recommended.

Laboratories use this Raloxifene standard for identity and assay testing, system suitability checks and method validation supporting ANDA and DMF filings. Typical end-use sectors are pharmaceutical manufacturing and academic and industrial research.

Available in 10 mg, 25 mg, 50 mg and 100 mg packs, Raloxifene is dispatched with a Certificate of Analysis (COA) to destinations worldwide.

Typical applications

Identification & assay
Method development & validation
QC reference material

Industries

Related to Raloxifene

View every impurity, metabolite and intermediate we list for Raloxifene.

Raloxifene impurities

Specifications & identifiers

Chemical identifiers
Product name	Raloxifene
Catalogue No.	VQ-007692
CAS Number	84449-90-1
Other CAS	82640-04-8
IUPAC name	[6-hydroxy-2-(4-hydroxyphenyl)-1-benzothiophen-3-yl]-[4-(2-piperidin-1-ylethoxy)phenyl]methanone
Molecular formula	C₂₈H₂₇NO₄S
Molecular weight	473.6 g/mol
Exact mass	473.1661
Grade	Reference Standard
HSN code	38229090
InChIKey	GZUITABIAKMVPG-UHFFFAOYSA-N
SMILES	C1CCN(CC1)CCOC2=CC=C(C=C2)C(=O)C3=C(SC4=C3C=CC(=C4)O)C5=CC=C(C=C5)O
PubChem CID	5035

Physical properties
Physical form	Solid
LogP (XLogP3)	6.1
H-bond donors / acceptors	2 / 6
TPSA	98.2 Å²
Synonyms	Keoxifene, Raloxifenum (Latin), 2-(4-hydroxyphenyl)-3-{4-[2-(piperidin-1-yl)ethoxy]benzoyl}-1-benzothiophen-6-ol, LY 139481, Raloxifene (INN), 2-(4-hydroxyphenyl)-3-({4-[2-(piperidin-1-yl)ethoxy]phenyl}carbonyl)-1-benzothiophen-6-ol, Pharoxifene, Raloxifene, 6, Eviden (TN), Raxeto (TN), Raloxifene (Standard)

Safety & hazard information (GHS)

Toxic

Harmful / irritant

Health hazard

Environmental hazard

Signal word: Danger

Hazard statements

H302Harmful if swallowed
H311Toxic in contact with skin
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
H360May damage fertility or the unborn child
H411Toxic to aquatic life with long lasting effects

Precautionary statements: P203, P261, P262, P264, P264 + P265, P270, P271, P273, P280, P301 + P317, P302 + P352, P304 + P340, P305 + P351 + P338, P316, P317, P318, P319, P321, P330, P332 + P317, P337 + P317, P361 + P364, P362 + P364, P391

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of Raloxifene?

The CAS Registry Number of Raloxifene is 84449-90-1. It is also known as Keoxifene, Raloxifenum (Latin), 2-(4-hydroxyphenyl)-3-{4-[2-(piperidin-1-yl)ethoxy]benzoyl}-1-benzothiophen-6-ol.

What is the molecular formula and molecular weight of Raloxifene?

Raloxifene has the molecular formula C28H27NO4S and a molecular weight of 473.6 g/mol. Its IUPAC name is [6-hydroxy-2-(4-hydroxyphenyl)-1-benzothiophen-3-yl]-[4-(2-piperidin-1-ylethoxy)phenyl]methanone.

What is Raloxifene used for?

Raloxifene is supplied as a characterised reference material related to Raloxifene. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of Raloxifene can I order?

We supply Raloxifene in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with Raloxifene?

Yes. Every lot of Raloxifene is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can Raloxifene be shipped internationally?

Yes. Raloxifene is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.