Vismodegib

About Vismodegib

Vismodegib is a high-purity reference standard of Vismodegib carrying the CAS registry number 879085-55-9. Formula C19H14Cl2N2O3S, molecular weight 421.3 g/mol. Systematically, it is named 2-chloro-N-(4-chloro-3-pyridin-2-ylphenyl)-4-methylsulfonylbenzamide. Alternative names: Erivedge and GDC 0449.

It is supplied as a solid. Keep the vial tightly closed, protected from light and humidity, at the temperature stated on the Certificate of Analysis. Under GHS it is labelled “Danger”, so handle it with suitable PPE and consult the SDS.

Laboratories use this Vismodegib standard for identity and assay testing, system suitability checks and method validation supporting ANDA and DMF filings. Our customers for this product work in pharmaceutical manufacturing and academic and industrial research.

Standard pack sizes are 10 mg, 25 mg, 50 mg and 100 mg, and every batch ships with a Certificate of Analysis (COA) and we export worldwide. This item is currently in stock for prompt dispatch.

Typical applications

Identification & assay
Method development & validation
QC reference material

Industries

Related to Vismodegib

View every impurity, metabolite and intermediate we list for Vismodegib.

Vismodegib impurities

Specifications & identifiers

Chemical identifiers
Product name	Vismodegib
Catalogue No.	VQ-007851
CAS Number	879085-55-9
IUPAC name	2-chloro-N-(4-chloro-3-pyridin-2-ylphenyl)-4-methylsulfonylbenzamide
Molecular formula	C₁₉H₁₄Cl₂N₂O₃S
Molecular weight	421.3 g/mol
Exact mass	420.0102
Grade	Reference Standard
HSN code	38229090
InChIKey	BPQMGSKTAYIVFO-UHFFFAOYSA-N
SMILES	CS(=O)(=O)C1=CC(=C(C=C1)C(=O)NC2=CC(=C(C=C2)Cl)C3=CC=CC=N3)Cl
PubChem CID	24776445

Physical properties
Physical form	Solid
LogP (XLogP3)	3.8
H-bond donors / acceptors	1 / 4
TPSA	84.5 Å²
Synonyms	2-Chloro-N-[4-chloro-3-(2-pyridinyl)phenyl]-4-(methylsulfonyl)benzamide, Erivedge, GDC 0449, GDC-0449, 2-chloro-N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(methylsulfonyl)benzamide, 2-chloro-N-[4-chloro-3-(pyridin-2-yl)phenyl]-4-(methylsulfonyl)benzamide, Benzamide, 2-chloro-N-(4-chloro-3-(2-pyridinyl)phenyl)-4-(methylsulfonyl)-, R3616 cpd, Hedgehog Antagonist GDC-0449, Vismodegib (GDC-0449), 2-chloro-N-(4-chloro-3-pyridin-2-yl-phenyl)-4-methanesulfonyl-benzamide, 2-Chloranyl-~{n}-(4-Chloranyl-3-Pyridin-2-Yl-Phenyl)-4-Methylsulfonyl-Benzamide

Safety & hazard information (GHS)

Harmful / irritant

Health hazard

Environmental hazard

Signal word: Danger

Hazard statements

H302+H312+H332Harmful if swallowed, in contact with skin or if inhaled
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
H360May damage fertility or the unborn child
H373May causes damage to organs through prolonged or repeated exposure
H400Very toxic to aquatic life
H410Very toxic to aquatic life with long lasting effects

Precautionary statements: P203, P260, P261, P264, P264 + P265, P270, P271, P273, P280, P301 + P317, P302 + P352, P304 + P340, P305 + P351 + P338, P317, P318, P319, P321, P330, P332 + P317, P337 + P317, P362 + P364, P391, P403 + P233, P405

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of Vismodegib?

The CAS Registry Number of Vismodegib is 879085-55-9. It is also known as 2-Chloro-N-[4-chloro-3-(2-pyridinyl)phenyl]-4-(methylsulfonyl)benzamide, Erivedge, GDC 0449.

What is the molecular formula and molecular weight of Vismodegib?

Vismodegib has the molecular formula C19H14Cl2N2O3S and a molecular weight of 421.3 g/mol. Its IUPAC name is 2-chloro-N-(4-chloro-3-pyridin-2-ylphenyl)-4-methylsulfonylbenzamide.

What is Vismodegib used for?

Vismodegib is supplied as a characterised reference material related to Vismodegib. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of Vismodegib can I order?

We supply Vismodegib in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg, 250 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with Vismodegib?

Yes. Every lot of Vismodegib is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can Vismodegib be shipped internationally?

Yes. Vismodegib is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.