Nilotinib monohydrochloride monohydrate

Name: Nilotinib monohydrochloride monohydrate
Brand: Vaqora Chemicals
SKU: VQ-013657

About Nilotinib monohydrochloride monohydrate

Vaqora Chemicals supplies Nilotinib monohydrochloride monohydrate, a process intermediate or related compound of Nilotinib registered under CAS number 923288-90-8. Formula C28H25ClF3N7O2, molecular weight 584.0 g/mol. Common synonyms include Nilotinib hydrochloride hydrate and Nilotinib hydrochloride monohydrate.

The product is provided as a solid. Reference materials should be stored sealed and away from light and moisture, as specified on the accompanying COA. It carries the GHS signal word “Warning” with 3 hazard statements. Review the Safety Data Sheet before use.

It is a process intermediate or related compound in the synthesis of Nilotinib, useful for route development, impurity fate-and-purge studies and analytical method development. Buyers come mainly from pharmaceutical manufacturing and academic and industrial research.

Vaqora Chemicals supplies Nilotinib monohydrochloride monohydrate in 10 mg, 25 mg, 50 mg and 100 mg packs, each shipped with a Certificate of Analysis (COA), and exports worldwide.

Typical applications

API route development
Impurity fate & purge studies
Analytical method development

Industries

Related to Nilotinib

View every impurity, metabolite and intermediate we list for Nilotinib.

Nilotinib impurities

Specifications & identifiers

Chemical identifiers
Product name	Nilotinib monohydrochloride monohydrate
Catalogue No.	VQ-013657
CAS Number	923288-90-8
IUPAC name	4-methyl-N-[3-(4-methylimidazol-1-yl)-5-(trifluoromethyl)phenyl]-3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]benzamide;hydrate;hydrochloride
Molecular formula	C₂₈H₂₅ClF₃N₇O₂
Molecular weight	584 g/mol
Exact mass	583.171
Grade	Reference Standard
HSN code	2933
InChIKey	YCBPQSYLYYBPDW-UHFFFAOYSA-N
SMILES	CC1=C(C=C(C=C1)C(=O)NC2=CC(=CC(=C2)C(F)(F)F)N3C=C(N=C3)C)NC4=NC=CC(=N4)C5=CN=CC=C5.O.Cl
PubChem CID	16757572

Physical properties
Physical form	Solid
H-bond donors / acceptors	4 / 10
TPSA	98.6 Å²
Synonyms	Nilotinib hydrochloride hydrate, Nilotinib hydrochloride monohydrate, Nilotinib hydrochloride monohydrate [Orange Book], Nilotinib hydrochloride hydrate (JAN), 641571-10-0, Nilotinib, Nilotinib HCl monohydrate, Nilotinib HCl hydrate, Nilotinib (monohydrochloride monohydrate), 923288-90-8 (HCl hydrate), AMN107 (monohydrochloride monohydrate), Nilotinib (as hydrochloride), Nilotinib hydrochlo

Safety & hazard information (GHS)

Harmful / irritant

Environmental hazard

Signal word: Warning

Hazard statements

H302Harmful if swallowed
H317May cause an allergic skin reaction
H410Very toxic to aquatic life with long lasting effects

Precautionary statements: P261, P264, P270, P272, P273, P280, P301 + P317, P302 + P352, P321, P330, P333 + P317, P362 + P364, P391, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of Nilotinib monohydrochloride monohydrate?

The CAS Registry Number of Nilotinib monohydrochloride monohydrate is 923288-90-8. It is also known as Nilotinib hydrochloride hydrate, Nilotinib hydrochloride monohydrate, Nilotinib hydrochloride monohydrate [Orange Book].

What is the molecular formula and molecular weight of Nilotinib monohydrochloride monohydrate?

Nilotinib monohydrochloride monohydrate has the molecular formula C28H25ClF3N7O2 and a molecular weight of 584 g/mol.

What is Nilotinib monohydrochloride monohydrate used for?

Nilotinib monohydrochloride monohydrate is supplied as a characterised reference material related to Nilotinib. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of Nilotinib monohydrochloride monohydrate can I order?

We supply Nilotinib monohydrochloride monohydrate in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with Nilotinib monohydrochloride monohydrate?

Yes. Every lot of Nilotinib monohydrochloride monohydrate is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can Nilotinib monohydrochloride monohydrate be shipped internationally?

Yes. Nilotinib monohydrochloride monohydrate is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.