Pacritinib

Name: Pacritinib
Brand: Vaqora Chemicals
SKU: VQ-040227

About Pacritinib

Pacritinib (CAS 937272-79-2) is an API reference standard offered by Vaqora Chemicals. With the molecular formula C28H32N4O3, it has a molar mass of 472.6 g/mol. It is also known as ONX-0803 or Oral JAK2 Inhibitor SB1518.

It is supplied as a solid. Keep the vial tightly closed, protected from light and humidity, at the temperature stated on the Certificate of Analysis. Under GHS it is labelled “Danger”, so handle it with suitable PPE and consult the SDS.

As a reference sample of the parent drug substance, it is used for identification, assay and impurity-profiling work during analytical method development, validation (AMV) and routine QC. It is used across pharmaceutical manufacturing and academic and industrial research.

Standard pack sizes are 10 mg, 25 mg, 50 mg and 100 mg, and every batch ships with a Certificate of Analysis (COA) and we export worldwide.

Typical applications

Identification & assay
Method development & validation
QC reference material

Industries

Specifications & identifiers

Chemical identifiers
Product name	Pacritinib
Catalogue No.	VQ-040227
CAS Number	937272-79-2
IUPAC name	(16E)-11-(2-pyrrolidin-1-ylethoxy)-14,19-dioxa-5,7,27-triazatetracyclo[19.3.1.12,6.18,12]heptacosa-1(24),2(27),3,5,8(26),9,11,16,21(25),22-decaene
Molecular formula	C₂₈H₃₂N₄O₃
Molecular weight	472.6 g/mol
Exact mass	472.2474
Grade	Reference Standard
HSN code	38229090
InChIKey	HWXVIOGONBBTBY-ONEGZZNKSA-N
SMILES	C1CCN(C1)CCOC2=C3COC/C=C/COCC4=CC(=CC=C4)C5=NC(=NC=C5)NC(=C3)C=C2
PubChem CID	46216796

Physical properties
Physical form	Solid
LogP (XLogP3)	3.8
H-bond donors / acceptors	1 / 7
TPSA	68.7 Å²
Synonyms	ONX-0803, Oral JAK2 Inhibitor SB1518, Pacritinib (SB1518), Pacritinib(SB1518), SB-1518 TFA salt, EX-A240

Safety & hazard information (GHS)

Health hazard

Environmental hazard

Signal word: Danger

Hazard statements

H360May damage fertility or the unborn child
H373May causes damage to organs through prolonged or repeated exposure
H410Very toxic to aquatic life with long lasting effects

Precautionary statements: P203, P260, P273, P280, P318, P319, P391, P405, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of Pacritinib?

The CAS Registry Number of Pacritinib is 937272-79-2. It is also known as ONX-0803, Oral JAK2 Inhibitor SB1518, Pacritinib (SB1518).

What is the molecular formula and molecular weight of Pacritinib?

Pacritinib has the molecular formula C28H32N4O3 and a molecular weight of 472.6 g/mol. Its IUPAC name is (16E)-11-(2-pyrrolidin-1-ylethoxy)-14,19-dioxa-5,7,27-triazatetracyclo[19.3.1.12,6.18,12]heptacosa-1(24),2(27),3,5,8(26),9,11,16,21(25),22-decaene.

Which grade and pack sizes of Pacritinib can I order?

We supply Pacritinib in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with Pacritinib?

Yes. Every lot of Pacritinib is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can Pacritinib be shipped internationally?

Yes. Pacritinib is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.