Sonidegib

Name: Sonidegib
Brand: Vaqora Chemicals
SKU: VQ-033921

About Sonidegib

Listed under CAS 956697-53-3, Sonidegib is a high-purity reference standard of Sonidegib available from Vaqora Chemicals. With the molecular formula C26H26F3N3O3, it has a molar mass of 485.5 g/mol. The IUPAC name is N-[6-[(2R,6S)-2,6-dimethylmorpholin-4-yl]-3-pyridinyl]-2-methyl-3-[4-(trifluoromethoxy)phenyl]benzamide. It is also known as LDE-225 or LDE 225.

The product is provided as a solid. Reference materials should be stored sealed and away from light and moisture, as specified on the accompanying COA. The GHS classification uses the signal word “Warning”, so appropriate gloves, eye protection and ventilation are recommended.

Laboratories use this Sonidegib standard for identity and assay testing, system suitability checks and method validation supporting ANDA and DMF filings. It is used across pharmaceutical manufacturing and academic and industrial research.

We offer Sonidegib in 10 mg, 25 mg, 50 mg and 100 mg packs with a batch-specific COA, and ship to customers worldwide.

Typical applications

Identification & assay
Method development & validation
QC reference material

Industries

Related to Sonidegib

View every impurity, metabolite and intermediate we list for Sonidegib.

Sonidegib impurities

Specifications & identifiers

Chemical identifiers
Product name	Sonidegib
Catalogue No.	VQ-033921
CAS Number	956697-53-3
IUPAC name	N-[6-[(2R,6S)-2,6-dimethylmorpholin-4-yl]-3-pyridinyl]-2-methyl-3-[4-(trifluoromethoxy)phenyl]benzamide
Molecular formula	C₂₆H₂₆F₃N₃O₃
Molecular weight	485.5 g/mol
Exact mass	485.1926
Grade	Reference Standard
HSN code	38229090
InChIKey	VZZJRYRQSPEMTK-CALCHBBNSA-N
SMILES	C[C@@H]1CN(C[C@@H](O1)C)C2=NC=C(C=C2)NC(=O)C3=CC=CC(=C3C)C4=CC=C(C=C4)OC(F)(F)F
PubChem CID	24775005

Physical properties
Physical form	Solid
LogP (XLogP3)	5.8
H-bond donors / acceptors	1 / 8
TPSA	63.7 Å²
Synonyms	LDE-225, LDE 225, Smoothened Antagonist LDE225, LDE225 (NVP-LDE225,Erismodegib), Sonidegib (LDE-225), Sonidegib (NVP-LDE225), Sonidegib phospate, EX-A409

Safety & hazard information (GHS)

Harmful / irritant

Signal word: Warning

Hazard statements

H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation

Precautionary statements: P261, P264, P264 + P265, P270, P271, P280, P301 + P317, P302 + P352, P304 + P340, P305 + P351 + P338, P319, P321, P330, P332 + P317, P337 + P317, P362 + P364, P403 + P233, P405, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of Sonidegib?

The CAS Registry Number of Sonidegib is 956697-53-3. It is also known as LDE-225, LDE 225, Smoothened Antagonist LDE225.

What is the molecular formula and molecular weight of Sonidegib?

Sonidegib has the molecular formula C26H26F3N3O3 and a molecular weight of 485.5 g/mol. Its IUPAC name is N-[6-[(2R,6S)-2,6-dimethylmorpholin-4-yl]-3-pyridinyl]-2-methyl-3-[4-(trifluoromethoxy)phenyl]benzamide.

What is Sonidegib used for?

Sonidegib is supplied as a characterised reference material related to Sonidegib. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of Sonidegib can I order?

We supply Sonidegib in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with Sonidegib?

Yes. Every lot of Sonidegib is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can Sonidegib be shipped internationally?

Yes. Sonidegib is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.