Impurity reference standards
Apixaban impurities & reference standards
Characterised Apixaban impurities, degradation products and related compounds for analytical method development, validation, QC release and regulatory filings.
131reference materials
4nitrosamine impurities
2isotope-labelled
COAHPLC · NMR · MS on request
(E)-Ethyl 2-(2-(4-methoxyphenyl)hydrazono)propanoate
- CAS
- 4792-57-8
- Formula
- C12H16N2O3
- MW
- 236.27 g/mol
VQ-024320
(Z)-2-Chloro-2-(2-(4-methoxyphenyl)hydrazineylidene) acetic acid
- CAS
- 40345-06-0
- Formula
- C9H9ClN2O3
- MW
- 228.63 g/mol
VQ-029182
(Z)-Ethyl 2-chloro-2-(2-(3-methoxyphenyl)hydrazono)acetate
- CAS
- 405872-78-8
- Formula
- C11H13ClN2O3
- MW
- 256.68 g/mol
VQ-024326
1-(2-Aminophenyl)-3-morpholino-5,6-dihydropyridin-2(1H)-one
- CAS
- 2444918-46-9
- Formula
- C15H19N3O2
- MW
- 273.33 g/mol
VQ-035761
1-(3-Aminophenyl)-3-morpholino-5,6-dihydropyridin-2(1H)-one
- CAS
- 2437650-75-2
- Formula
- C15H19N3O2
- MW
- 273.33 g/mol
VQ-047418
1-(4-(2-Methyl-6-oxopiperidin-1-yl)phenyl)-3-morpholino-5,6-dihydropyridin-2(1H)-one
- CAS
- 2098457-93-1
- Formula
- C21H27N3O3
- MW
- 369.5 g/mol
VQ-035759
1-(4-(2-Oxopiperidin-1-yl)phenyl)-5,6-dihydropyridin-2(1H)-one
- CAS
- 2458125-22-7
- Formula
- C16H18N2O2
- MW
- 270.33 g/mol
VQ-047417
1-(4-(5-Methyl-2-oxopiperidin-1-yl)phenyl)-3-morpholino-5,6-dihydropyridin-2(1H)-one
- CAS
- 1686149-78-9
- Formula
- C21H27N3O3
- MW
- 369.5 g/mol
VQ-021605
1-(4-Aminophenyl)-3-morpholino-5,6-dihydropyridin-2(1H)-one
- CAS
- 1267610-26-3
- Formula
- C15H19N3O2
- MW
- 273.33 g/mol
VQ-012837
1-(4-Iodophenyl)-3-morpholino-5,6-dihydropyridin-2(1H)-one
- CAS
- 473927-69-4
- Formula
- C15H17IN2O2
- MW
- 384.21 g/mol
VQ-044496
![1-(4-Methoxyphenyl)-6-(4-(2-methyl-6-oxopiperidin-1-yl)phenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxamide chemical structure](/media/structures/BDNVCXVQYXUHCR-UHFFFAOYSA-N.svg)
1-(4-Methoxyphenyl)-6-(4-(2-methyl-6-oxopiperidin-1-yl)phenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxamide
- CAS
- 2098457-92-0
- Formula
- C26H27N5O4
- MW
- 473.5 g/mol
VQ-020812
![1-(4-Methoxyphenyl)-6-(4-(5-methyl-2-oxopiperidin-1-yl)phenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxamide chemical structure](/media/structures/NNYVHGAEKIMTND-UHFFFAOYSA-N.svg)
1-(4-Methoxyphenyl)-6-(4-(5-methyl-2-oxopiperidin-1-yl)phenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxamide
- CAS
- 1686149-74-5
- Formula
- C26H27N5O4
- MW
- 473.5 g/mol
VQ-020813
![1-(4-Methoxyphenyl)-6-(4-nitrophenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxamide chemical structure](/media/structures/BPTMUXLZPUZVQT-UHFFFAOYSA-N.svg)
1-(4-Methoxyphenyl)-6-(4-nitrophenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxamide
- CAS
- 1642569-42-3
- Formula
- C20H17N5O5
- MW
- 407.4 g/mol
VQ-047419
![1-(4-Methoxyphenyl)-7-oxo-6-(4-(2-oxoazepan-1-yl)phenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxamide chemical structure](/media/structures/LUIIVYXZQHQSEH-UHFFFAOYSA-N.svg)
1-(4-Methoxyphenyl)-7-oxo-6-(4-(2-oxoazepan-1-yl)phenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxamide
- CAS
- 1074549-87-3
- Formula
- C26H27N5O4
- MW
- 473.5 g/mol
VQ-043043
![1-(4-Methoxyphenyl)-7-oxo-6-(4-(2-oxopyrrolidin-1-yl)phenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxamide chemical structure](/media/structures/XOAWHQBWIYBHCF-UHFFFAOYSA-N.svg)
1-(4-Methoxyphenyl)-7-oxo-6-(4-(2-oxopyrrolidin-1-yl)phenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxamide
- CAS
- 1777781-49-3
- Formula
- C24H23N5O4
- MW
- 445.5 g/mol
VQ-029184
2-Chloro-2-(phenylhydrazono)acetic Acid Ethyl Ester
- CAS
- 28663-68-5
- Formula
- C10H11ClN2O2
- MW
- 226.66 g/mol
VQ-024327
![2-Hydroxyethyl,1-(4-methoxyphenyl)-7-oxo-6-(4-(2-oxopiperidin-1-yl)phenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylate chemical structure](/media/structures/OECIQQSCSYNPEJ-UHFFFAOYSA-N.svg)
2-Hydroxyethyl,1-(4-methoxyphenyl)-7-oxo-6-(4-(2-oxopiperidin-1-yl)phenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylate
- CAS
- 1904628-10-9
- Formula
- C27H28N4O6
- MW
- 504.5 g/mol
VQ-024316
3-(Morpholinyl)-N-(4-nitrophenyl)-5,6-dihydropyridin-2-one
- CAS
- 503615-03-0
- Formula
- C15H17N3O4
- MW
- 303.31 g/mol
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3-Carbamoyl-1-(4-methoxyphenyl)-4-(2-(4-(2-oxopiperidin-1-yl)phenylamino)ethyl)-1H-pyrazole-5-carboxylic Acid
- CAS
- 2206825-81-0
- Formula
- C25H27N5O5
- MW
- 477.5 g/mol
VQ-024315
3-Morpholino-1-(3-nitrophenyl)-5,6-dihydropyridin-2(1H)-one
- CAS
- 2443747-50-8
- Formula
- C15H17N3O4
- MW
- 303.31 g/mol
VQ-029185
3-Morpholino-1-(4-(2-oxopiperidin-1-yl)phenyl)-5,6-dihydropyridin-2(1H)-one
- CAS
- 545445-44-1
- Formula
- C20H25N3O3
- MW
- 355.4 g/mol
VQ-027174
3-Morpholino-1-(4-(2-oxopiperidin-1-yl)phenyl)pyridin-2(1H)-one
- CAS
- 2413365-22-5
- Formula
- C20H23N3O3
- MW
- 353.4 g/mol
VQ-021604
3,5-Dichloro-1-(4-nitrophenyl)-5,6-dihydropyridin-2(1H)-one
- CAS
- 2518374-75-7
- Formula
- C11H8Cl2N2O3
- MW
- 287.1 g/mol
VQ-044137
![6-(4-(5-Chloropentanamido)phenyl)-1-(4-methoxyphenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxamide chemical structure](/media/structures/RYEXWTWVQUUZFL-UHFFFAOYSA-N.svg)
6-(4-(5-Chloropentanamido)phenyl)-1-(4-methoxyphenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxamide
- CAS
- 1449510-64-8
- Formula
- C25H26ClN5O4
- MW
- 496 g/mol
VQ-020815
FAQs — Apixaban impurities
Which Apixaban impurities do you supply?
We list 131 Apixaban-related reference materials, including process impurities, degradation products, nitrosamine impurities, stable-isotope-labelled standards and related compounds. Each is supplied with a COA, and characterisation data (HPLC, 1H-NMR, MS, IR) can be provided on request.
What are Apixaban impurity standards used for?
They are used for analytical method development and validation, impurity identification and quantification, forced-degradation and stability studies, and to support ANDA, DMF and other regulatory submissions under ICH Q3A/Q3B (and ICH M7 for mutagenic impurities).
Can you synthesise a Apixaban impurity that is not listed?
Yes. Our custom synthesis service can prepare and characterise unlisted impurities, metabolites and labelled analogues from milligram to gram scale. Share the structure or name and required quantity for a quotation.
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