10-Formylfolic acid

Name: 10-Formylfolic acid
Brand: Vaqora Chemicals
SKU: VQ-021961

About 10-Formylfolic acid

Listed under CAS 134-05-4, 10-Formylfolic acid is an impurity of Levofolinate available from Vaqora Chemicals. With the molecular formula C20H19N7O7, it has a molar mass of 469.4 g/mol. Systematically, it is named (2S)-2-[[4-[(2-amino-4-oxo-3H-pteridin-6-yl)methyl-formylamino]benzoyl]amino]pentanedioic acid. Alternative names: formylfolic acid and 10-Formylpteroylglutamic Acid.

The product is provided as a solid. Keep the vial tightly closed, protected from light and humidity, at the temperature stated on the Certificate of Analysis. Under GHS it is labelled “Danger”, so handle it with suitable PPE and consult the SDS.

Pharmaceutical QC and development laboratories use this impurity standard of Levofolinate to develop and validate HPLC methods, to set specification limits and to document impurity profiles in ANDA and DMF submissions. Typical end-use sectors are pharmaceutical manufacturing and academic and industrial research.

Available in 10 mg, 25 mg, 50 mg and 100 mg packs, 10-Formylfolic acid is dispatched with a Certificate of Analysis (COA) to destinations worldwide.

Typical applications

Analytical method development
Method validation (AMV)
QC release testing
ANDA / DMF filings

Industries

Related to Levofolinate

View every impurity, metabolite and intermediate we list for Levofolinate.

Levofolinate impurities

Specifications & identifiers

Chemical identifiers
Product name	10-Formylfolic acid
Catalogue No.	VQ-021961
CAS Number	134-05-4
IUPAC name	(2S)-2-[[4-[(2-amino-4-oxo-3H-pteridin-6-yl)methyl-formylamino]benzoyl]amino]pentanedioic acid
Molecular formula	C₂₀H₁₉N₇O₇
Molecular weight	469.4 g/mol
Exact mass	469.1346
Grade	Reference Standard
HSN code	38229090
InChIKey	UGWUWNVTCLDEOG-ZDUSSCGKSA-N
SMILES	C1=CC(=CC=C1C(=O)N[C@@H](CCC(=O)O)C(=O)O)N(CC2=CN=C3C(=N2)C(=O)NC(=N3)N)C=O
PubChem CID	135405023

Physical properties
Physical form	Solid
LogP (XLogP3)	-1.7
H-bond donors / acceptors	5 / 10
TPSA	217 Å²
Synonyms	formylfolic acid, 10-Formylpteroylglutamic Acid, N-[4-[[(2-Amino-3,4-dihydro-4-oxo-6-pteridinyl)methyl]formylamino]benzoyl]-L-glutamic Acid, N10-Formylfolic Acid, N10-Formylf olic acid, Glutamic acid, N-[p-[N-[(2-amino-4-hydroxy-6-pteridinyl)methyl]formamido]benzoyl]-, Glutamic acid, N-[p-[N-[(2-amino-4-hydroxy-6-pteridinyl)methyl]formamido]benzoyl]-, L-, N-(4-{N-[(2-Amino-4-oxo-1,4-dihydropteridin-6-yl)methyl]formamido}benzoyl)-L-glutamic acid

Safety & hazard information (GHS)

Health hazard

Signal word: Danger

Hazard statements

H317May cause an allergic skin reaction
H334May cause allergy or asthma symptoms or breathing difficulties if inhaled

Precautionary statements: P233, P260, P261, P271, P272, P280, P284, P302 + P352, P304 + P340, P321, P333 + P317, P342 + P316, P362 + P364, P403, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of 10-Formylfolic acid?

The CAS Registry Number of 10-Formylfolic acid is 134-05-4. It is also known as formylfolic acid, 10-Formylpteroylglutamic Acid, N-[4-[[(2-Amino-3,4-dihydro-4-oxo-6-pteridinyl)methyl]formylamino]benzoyl]-L-glutamic Acid.

What is the molecular formula and molecular weight of 10-Formylfolic acid?

10-Formylfolic acid has the molecular formula C20H19N7O7 and a molecular weight of 469.4 g/mol. Its IUPAC name is (2S)-2-[[4-[(2-amino-4-oxo-3H-pteridin-6-yl)methyl-formylamino]benzoyl]amino]pentanedioic acid.

What is 10-Formylfolic acid used for?

10-Formylfolic acid is supplied as a characterised reference material related to Levofolinate. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of 10-Formylfolic acid can I order?

We supply 10-Formylfolic acid in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with 10-Formylfolic acid?

Yes. Every lot of 10-Formylfolic acid is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can 10-Formylfolic acid be shipped internationally?

Yes. 10-Formylfolic acid is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.