Dihydro Folic Acid

Name: Dihydro Folic Acid
Brand: Vaqora Chemicals
SKU: VQ-024075

About Dihydro Folic Acid

Dihydro Folic Acid (CAS 4033-27-6) is an impurity of Levofolinate offered by Vaqora Chemicals. Its molecular formula is C19H21N7O6 and its molecular weight is 443.4 g/mol. Its systematic (IUPAC) name is (2S)-2-[[4-[(2-amino-4-oxo-7,8-dihydro-3H-pteridin-6-yl)methylamino]benzoyl]amino]pentanedioic acid. Common synonyms include 7,8-Dihydrofolicacid and dihydrofolate.

It is supplied as a solid. Store the standard in its sealed vial, protected from light and moisture, and follow the storage condition printed on the COA. The GHS classification uses the signal word “Warning”, so appropriate gloves, eye protection and ventilation are recommended.

This Levofolinate impurity supports analytical method development and validation (AMV), batch release testing and the impurity sections of ANDA and DMF filings. Typical end-use sectors are pharmaceutical manufacturing and academic and industrial research.

Standard pack sizes are 10 mg, 25 mg, 50 mg and 100 mg, and every batch ships with a Certificate of Analysis (COA) and we export worldwide.

Typical applications

Analytical method development
Method validation (AMV)
QC release testing
ANDA / DMF filings

Industries

Related to Levofolinate

View every impurity, metabolite and intermediate we list for Levofolinate.

Levofolinate impurities

Specifications & identifiers

Chemical identifiers
Product name	Dihydro Folic Acid
Catalogue No.	VQ-024075
CAS Number	4033-27-6
IUPAC name	(2S)-2-[[4-[(2-amino-4-oxo-7,8-dihydro-3H-pteridin-6-yl)methylamino]benzoyl]amino]pentanedioic acid
Molecular formula	C₁₉H₂₁N₇O₆
Molecular weight	443.4 g/mol
Exact mass	443.1553
Grade	Reference Standard
HSN code	38229090
InChIKey	OZRNSSUDZOLUSN-LBPRGKRZSA-N
SMILES	C1C(=NC2=C(N1)N=C(NC2=O)N)CNC3=CC=C(C=C3)C(=O)N[C@@H](CCC(=O)O)C(=O)O
PubChem CID	135398604

Physical properties
Physical form	Solid
LogP (XLogP3)	-0.9
H-bond donors / acceptors	7 / 10
TPSA	208 Å²
Synonyms	7,8-Dihydrofolicacid, dihydrofolate, 7,8-Dihydrofolic acid, 7,8-Dihydropteroylglutamate, 7,8-Dihydropteroyl-L-glutamic acid, 7,8-Dihydro-L-folic acid, N-(7,8-dihydropteroyl)-L-glutamic acid, H2PteGlu, H2PteGlu1, (s)-2-(((9h-fluoren-9-yl)methoxy)carbonylamino)-3-phenylpropanoic acid

Safety & hazard information (GHS)

Harmful / irritant

Signal word: Warning

Hazard statements

H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation

Precautionary statements: P261, P264, P264 + P265, P271, P280, P302 + P352, P304 + P340, P305 + P351 + P338, P319, P321, P332 + P317, P337 + P317, P362 + P364, P403 + P233, P405, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of Dihydro Folic Acid?

The CAS Registry Number of Dihydro Folic Acid is 4033-27-6. It is also known as 7,8-Dihydrofolicacid, dihydrofolate, 7,8-Dihydrofolic acid.

What is the molecular formula and molecular weight of Dihydro Folic Acid?

Dihydro Folic Acid has the molecular formula C19H21N7O6 and a molecular weight of 443.4 g/mol. Its IUPAC name is (2S)-2-[[4-[(2-amino-4-oxo-7,8-dihydro-3H-pteridin-6-yl)methylamino]benzoyl]amino]pentanedioic acid.

What is Dihydro Folic Acid used for?

Dihydro Folic Acid is supplied as a characterised reference material related to Levofolinate. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of Dihydro Folic Acid can I order?

We supply Dihydro Folic Acid in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with Dihydro Folic Acid?

Yes. Every lot of Dihydro Folic Acid is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can Dihydro Folic Acid be shipped internationally?

Yes. Dihydro Folic Acid is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.