10-Propargyl-10-deazaminopterin Diethyl Ester 146464-94-0

Name: 10-Propargyl-10-deazaminopterin Diethyl Ester
Brand: Vaqora Chemicals
SKU: VQ-041577

About 10-Propargyl-10-deazaminopterin Diethyl Ester

Vaqora Chemicals supplies 10-Propargyl-10-deazaminopterin Diethyl Ester, an impurity of Pralatrexate registered under CAS number 146464-94-0. Formula C27H31N7O5, molecular weight 533.6 g/mol. The IUPAC name is diethyl (2S)-2-[[4-[1-(2,4-diaminopteridin-6-yl)pent-4-yn-2-yl]benzoyl]amino]pentanedioate.

It is supplied as a solid. Store the standard in its sealed vial, protected from light and moisture, and follow the storage condition printed on the COA. Under GHS it is labelled “Danger”, so handle it with suitable PPE and consult the SDS.

This Pralatrexate impurity supports analytical method development and validation (AMV), batch release testing and the impurity sections of ANDA and DMF filings. Our customers for this product work in pharmaceutical manufacturing and academic and industrial research.

Standard pack sizes are 10 mg, 25 mg, 50 mg and 100 mg, and every batch ships with a Certificate of Analysis (COA) and we export worldwide.

Typical applications

Analytical method development
Method validation (AMV)
QC release testing
ANDA / DMF filings

Industries

Related to Pralatrexate

View every impurity, metabolite and intermediate we list for Pralatrexate.

Pralatrexate impurities

Specifications & identifiers

Chemical identifiers
Product name	10-Propargyl-10-deazaminopterin Diethyl Ester
Catalogue No.	VQ-041577
CAS Number	146464-94-0
IUPAC name	diethyl (2S)-2-[[4-[1-(2,4-diaminopteridin-6-yl)pent-4-yn-2-yl]benzoyl]amino]pentanedioate
Molecular formula	C₂₇H₃₁N₇O₅
Molecular weight	533.6 g/mol
Exact mass	533.2387
Grade	Reference Standard
HSN code	38229090
InChIKey	XCONKISSMJXYPX-IJHRGXPZSA-N
SMILES	CCOC(=O)CC[C@@H](C(=O)OCC)NC(=O)C1=CC=C(C=C1)C(CC#C)CC2=CN=C3C(=N2)C(=NC(=N3)N)N
PubChem CID	14947208

Physical properties
Physical form	Solid
LogP (XLogP3)	1.9
H-bond donors / acceptors	3 / 11
TPSA	185 Å²

Safety & hazard information (GHS)

Toxic

Health hazard

Signal word: Danger

Hazard statements

H301Toxic if swallowed
H360May damage fertility or the unborn child

Precautionary statements: P203, P264, P270, P280, P301 + P316, P318, P321, P330, P405, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of 10-Propargyl-10-deazaminopterin Diethyl Ester?

The CAS Registry Number of 10-Propargyl-10-deazaminopterin Diethyl Ester is 146464-94-0. It is also known as 1,5-Diethyl N-[4-[1-[(2,4-diamino-6-pteridinyl)methyl]-3-butyn-1-yl]benzoyl]-L-glutamate, 1,5-Diethyl N-(4-(1-((2,4-diamino-6-pteridinyl)methyl)-3-butyn-1-yl)benzoyl)-L-glutamate, Diethyl N-{4-[1-(2,4-diaminopteridin-6-yl)pent-4-yn-2-yl]benzoyl}-L-glutamate.

What is the molecular formula and molecular weight of 10-Propargyl-10-deazaminopterin Diethyl Ester?

10-Propargyl-10-deazaminopterin Diethyl Ester has the molecular formula C27H31N7O5 and a molecular weight of 533.6 g/mol. Its IUPAC name is diethyl (2S)-2-[[4-[1-(2,4-diaminopteridin-6-yl)pent-4-yn-2-yl]benzoyl]amino]pentanedioate.

What is 10-Propargyl-10-deazaminopterin Diethyl Ester used for?

10-Propargyl-10-deazaminopterin Diethyl Ester is supplied as a characterised reference material related to Pralatrexate. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of 10-Propargyl-10-deazaminopterin Diethyl Ester can I order?

We supply 10-Propargyl-10-deazaminopterin Diethyl Ester in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with 10-Propargyl-10-deazaminopterin Diethyl Ester?

Yes. Every lot of 10-Propargyl-10-deazaminopterin Diethyl Ester is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can 10-Propargyl-10-deazaminopterin Diethyl Ester be shipped internationally?

Yes. 10-Propargyl-10-deazaminopterin Diethyl Ester is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.