11-(4-Methylpiperazin-1-yl)-5H-dibenzo[b,e][1… 1977-07-7

Name: 11-(4-Methylpiperazin-1-yl)-5H-dibenzo[b,e][1,4]diazepine
Brand: Vaqora Chemicals
SKU: VQ-029913

About 11-(4-Methylpiperazin-1-yl)-5H-dibenzo[b,e][1,4]diazepine

Listed under CAS 1977-07-7, 11-(4-Methylpiperazin-1-yl)-5H-dibenzo[b,e][1,4]diazepine is an impurity of Clozapine available from Vaqora Chemicals. The compound has the formula C18H20N4, corresponding to a molecular weight of 292.4 g/mol. The IUPAC name is 6-(4-methylpiperazin-1-yl)-11H-benzo[b][1,4]benzodiazepine. It is also known as Deschloro Clozapine or Dechloroclozapine.

It is supplied as a solid. Store the standard in its sealed vial, protected from light and moisture, and follow the storage condition printed on the COA. It carries the GHS signal word “Danger” with 1 hazard statement. Review the Safety Data Sheet before use.

Pharmaceutical QC and development laboratories use this impurity standard of Clozapine to develop and validate HPLC methods, to set specification limits and to document impurity profiles in ANDA and DMF submissions. Buyers come mainly from pharmaceutical manufacturing and academic and industrial research.

Available in 10 mg, 25 mg, 50 mg and 100 mg packs, 11-(4-Methylpiperazin-1-yl)-5H-dibenzo[b,e][1,4]diazepine is dispatched with a Certificate of Analysis (COA) to destinations worldwide.

Typical applications

Analytical method development
Method validation (AMV)
QC release testing
ANDA / DMF filings

Industries

Related to Clozapine

View every impurity, metabolite and intermediate we list for Clozapine.

Clozapine impurities

Specifications & identifiers

Chemical identifiers
Product name	11-(4-Methylpiperazin-1-yl)-5H-dibenzo[b,e][1,4]diazepine
Catalogue No.	VQ-029913
CAS Number	1977-07-7
IUPAC name	6-(4-methylpiperazin-1-yl)-11H-benzo[b][1,4]benzodiazepine
Molecular formula	C₁₈H₂₀N₄
Molecular weight	292.4 g/mol
Exact mass	292.1688
Grade	Reference Standard
HSN code	38229090
InChIKey	VQHITFFJBFOMBG-UHFFFAOYSA-N
SMILES	CN1CCN(CC1)C2=NC3=CC=CC=C3NC4=CC=CC=C42
PubChem CID	16103

Physical properties
Physical form	Solid
LogP (XLogP3)	2.4
H-bond donors / acceptors	1 / 3
TPSA	30.9 Å²
Synonyms	Deschloro Clozapine, Dechloroclozapine, 11-(4-Methyl-1-piperazinyl)-5H-dibenzo(b,e)(1,4)diazepine, 5H-DIBENZO(b,e)(1,4)DIAZEPINE, 11-(4-METHYL-1-PIPERAZINYL)-, 11-(4-Methyl-1-piperazinyl)-5H-dibenzo[b,e][1,4]diazepine, 5H-Dibenzo[b,e][1,4]diazepine, 11-(4-methyl-1-piperazinyl)-, Deschloroclozapine, Dopamine serotonin antagonist-1, Deschloroclozapine (DCZ), CS-M3647

Safety & hazard information (GHS)

Toxic

Signal word: Danger

Hazard statements

H301Toxic if swallowed

Precautionary statements: P264, P270, P301 + P316, P321, P330, P405, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of 11-(4-Methylpiperazin-1-yl)-5H-dibenzo[b,e][1,4]diazepine?

The CAS Registry Number of 11-(4-Methylpiperazin-1-yl)-5H-dibenzo[b,e][1,4]diazepine is 1977-07-7. It is also known as Deschloro Clozapine, Dechloroclozapine, 11-(4-Methyl-1-piperazinyl)-5H-dibenzo(b,e)(1,4)diazepine.

What is the molecular formula and molecular weight of 11-(4-Methylpiperazin-1-yl)-5H-dibenzo[b,e][1,4]diazepine?

11-(4-Methylpiperazin-1-yl)-5H-dibenzo[b,e][1,4]diazepine has the molecular formula C18H20N4 and a molecular weight of 292.4 g/mol. Its IUPAC name is 6-(4-methylpiperazin-1-yl)-11H-benzo[b][1,4]benzodiazepine.

What is 11-(4-Methylpiperazin-1-yl)-5H-dibenzo[b,e][1,4]diazepine used for?

11-(4-Methylpiperazin-1-yl)-5H-dibenzo[b,e][1,4]diazepine is supplied as a characterised reference material related to Clozapine. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of 11-(4-Methylpiperazin-1-yl)-5H-dibenzo[b,e][1,4]diazepine can I order?

We supply 11-(4-Methylpiperazin-1-yl)-5H-dibenzo[b,e][1,4]diazepine in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with 11-(4-Methylpiperazin-1-yl)-5H-dibenzo[b,e][1,4]diazepine?

Yes. Every lot of 11-(4-Methylpiperazin-1-yl)-5H-dibenzo[b,e][1,4]diazepine is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can 11-(4-Methylpiperazin-1-yl)-5H-dibenzo[b,e][1,4]diazepine be shipped internationally?

Yes. 11-(4-Methylpiperazin-1-yl)-5H-dibenzo[b,e][1,4]diazepine is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.