Clozapine-d8

Name: Clozapine-d8
Brand: Vaqora Chemicals
SKU: VQ-029914

About Clozapine-d8

Clozapine-d8 is a stable isotope labelled analogue related to Clozapine carrying the CAS registry number 1185053-50-2. Its molecular formula is C18H19ClN4 and its molecular weight is 334.9 g/mol. Its systematic (IUPAC) name is 3-chloro-6-(2,2,3,3,5,5,6,6-octadeuterio-4-methylpiperazin-1-yl)-11H-benzo[b][1,4]benzodiazepine. Common synonyms include TMIH-0166.

The product is provided as a solid. Reference materials should be stored sealed and away from light and moisture, as specified on the accompanying COA. Good laboratory practice and suitable PPE are recommended during handling.

Its mass shift relative to the unlabelled analyte makes it a dependable internal standard for LC-MS/MS assays, improving accuracy in bioanalysis, therapeutic drug monitoring and method validation. Buyers come mainly from pharmaceutical manufacturing and academic and industrial research.

Standard pack sizes are 10 mg, 25 mg, 50 mg and 100 mg, and every batch ships with a Certificate of Analysis (COA) and we export worldwide.

Typical applications

LC-MS/MS internal standard
Bioanalytical quantitation
Pharmacokinetic studies

Industries

Related to Clozapine

View every impurity, metabolite and intermediate we list for Clozapine.

Clozapine impurities

Grade guides

Specifications & identifiers

Chemical identifiers
Product name	Clozapine-d8
Catalogue No.	VQ-029914
CAS Number	1185053-50-2
IUPAC name	3-chloro-6-(2,2,3,3,5,5,6,6-octadeuterio-4-methylpiperazin-1-yl)-11H-benzo[b][1,4]benzodiazepine
Molecular formula	C₁₈H₁₉ClN₄
Molecular weight	334.9 g/mol
Exact mass	334.18
Grade	Reference Standard
HSN code	38229090
InChIKey	QZUDBNBUXVUHMW-JNJBWJDISA-N
SMILES	[2H]C1(C(N(C(C(N1C)([2H])[2H])([2H])[2H])C2=NC3=C(C=CC(=C3)Cl)NC4=CC=CC=C42)([2H])[2H])[2H]
PubChem CID	135858214

Physical properties
Physical form	Solid
LogP (XLogP3)	3.1
H-bond donors / acceptors	1 / 3
TPSA	30.9 Å²

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of Clozapine-d8?

The CAS Registry Number of Clozapine-d8 is 1185053-50-2. It is also known as TMIH-0166, 8-Chloro-11-(4-methyl-1-piperazinyl-d8)-5H-dibenzo[b,e][1,4]diazepine, 8-chloro-11-(4-methylpiperazin-1-yl-2,2,3,3,5,5,6,6-d8)-5H-dibenzo[b,e][1,4]diazepine.

What is the molecular formula and molecular weight of Clozapine-d8?

Clozapine-d8 has the molecular formula C18H19ClN4 and a molecular weight of 334.9 g/mol. Its IUPAC name is 3-chloro-6-(2,2,3,3,5,5,6,6-octadeuterio-4-methylpiperazin-1-yl)-11H-benzo[b][1,4]benzodiazepine.

What is Clozapine-d8 used for?

Clozapine-d8 is supplied as a characterised reference material related to Clozapine. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of Clozapine-d8 can I order?

We supply Clozapine-d8 in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with Clozapine-d8?

Yes. Every lot of Clozapine-d8 is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can Clozapine-d8 be shipped internationally?

Yes. We export Clozapine-d8 worldwide by air and sea freight or express courier, on EXW, FOB, CIF, CFR or DAP Incoterms, with full export documentation.