(1R,4S)-Sertraline

Name: (1R,4S)-Sertraline
Brand: Vaqora Chemicals
SKU: VQ-004262

About (1R,4S)-Sertraline

(1R,4S)-Sertraline (CAS 79951-46-5) is an impurity of Sertraline offered by Vaqora Chemicals. The compound has the formula C17H18Cl3N, corresponding to a molecular weight of 342.7 g/mol. The IUPAC name is (1S,4S)-4-(3,4-dichlorophenyl)-N-methyl-1,2,3,4-tetrahydronaphthalen-1-amine. Hydrochloride. Common synonyms include 1R,4S-trans-Sertraline and (1R,4S) Sertraline.

The product is provided as a solid. Store the standard in its sealed vial, protected from light and moisture, and follow the storage condition printed on the COA. Under GHS it is labelled “Warning”, so handle it with suitable PPE and consult the SDS.

Pharmaceutical QC and development laboratories use this impurity standard of Sertraline to develop and validate HPLC methods, to set specification limits and to document impurity profiles in ANDA and DMF submissions. Typical end-use sectors are pharmaceutical manufacturing and academic and industrial research.

Standard pack sizes are 10 mg, 25 mg, 50 mg and 100 mg, and every batch ships with a Certificate of Analysis (COA) and we export worldwide.

Typical applications

Analytical method development
Method validation (AMV)
QC release testing
ANDA / DMF filings

Industries

Related to Sertraline

View every impurity, metabolite and intermediate we list for Sertraline.

Sertraline impurities

Specifications & identifiers

Chemical identifiers
Product name	(1R,4S)-Sertraline
Catalogue No.	VQ-004262
CAS Number	79951-46-5
IUPAC name	(1S,4S)-4-(3,4-dichlorophenyl)-N-methyl-1,2,3,4-tetrahydronaphthalen-1-amine;hydrochloride
Molecular formula	C₁₇H₁₈Cl₃N
Molecular weight	342.7 g/mol
Exact mass	341.0505
Grade	Reference Standard
HSN code	38229090
InChIKey	BLFQGGGGFNSJKA-XHXSRVRCSA-N
SMILES	CN[C@H]1CC[C@H](C2=CC=CC=C12)C3=CC(=C(C=C3)Cl)Cl.Cl
PubChem CID	63009

Physical properties
Physical form	Solid
H-bond donors / acceptors	2 / 1
TPSA	12 Å²
Synonyms	(1R,4S)-4-(3,4-Dichlorophenyl)-1,2,3,4-tetrahydro-N-methyl-1-naphthalenamine, (1R-trans)-4-(3,4-Dichlorophenyl)-1,2,3,4-tetrahydro-N-methyl-1-naphthalenamine, 1R,4S-trans-Sertraline, (1R,4S) Sertraline, Sertraline hydrochloride, Sertraline HCl, (+)-sertraline hydrochloride, Sertraline (as hydrochloride), Hydrochloride, Sertraline, Sertraline Hydrochloride (1S-cis)-, (1S,4S)-4-(3,4-dichlorophenyl)-N-methyl-1,2,3,4-tetrahydronaphthalen-1-amine hydrochloride, Lustral

Safety & hazard information (GHS)

Harmful / irritant

Health hazard

Environmental hazard

Signal word: Warning

Hazard statements

H302Harmful if swallowed
H361Suspected of damaging fertility or the unborn child
H400Very toxic to aquatic life

Precautionary statements: P203, P264, P270, P273, P280, P301 + P317, P318, P330, P391, P405, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of (1R,4S)-Sertraline?

The CAS Registry Number of (1R,4S)-Sertraline is 79951-46-5. It is also known as (1R,4S)-4-(3,4-Dichlorophenyl)-1,2,3,4-tetrahydro-N-methyl-1-naphthalenamine, (1R-trans)-4-(3,4-Dichlorophenyl)-1,2,3,4-tetrahydro-N-methyl-1-naphthalenamine, 1R,4S-trans-Sertraline.

What is the molecular formula and molecular weight of (1R,4S)-Sertraline?

(1R,4S)-Sertraline has the molecular formula C17H18Cl3N and a molecular weight of 342.7 g/mol.

What is (1R,4S)-Sertraline used for?

(1R,4S)-Sertraline is supplied as a characterised reference material related to Sertraline. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of (1R,4S)-Sertraline can I order?

We supply (1R,4S)-Sertraline in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with (1R,4S)-Sertraline?

Yes. Every lot of (1R,4S)-Sertraline is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can (1R,4S)-Sertraline be shipped internationally?

Yes. (1R,4S)-Sertraline is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.