2,3,5-Trifluorophenylacetic acid

Name: 2,3,5-Trifluorophenylacetic acid
Brand: Vaqora Chemicals
SKU: VQ-033889

About 2,3,5-Trifluorophenylacetic acid

Vaqora Chemicals supplies 2,3,5-Trifluorophenylacetic acid, an impurity of Sitagliptin registered under CAS number 132992-28-0. The compound has the formula C8H5F3O2, corresponding to a molecular weight of 190.12 g/mol. The IUPAC name is 2-(2,3,5-trifluorophenyl)acetic acid. Alternative names: Benzeneacetic acid, 2,3,5-trifluoro- and 2,3,5-Trifluorobenzeneacetic acid.

It is supplied as a solid. Store the standard in its sealed vial, protected from light and moisture, and follow the storage condition printed on the COA. Under GHS it is labelled “Warning”, so handle it with suitable PPE and consult the SDS.

Pharmaceutical QC and development laboratories use this impurity standard of Sitagliptin to develop and validate HPLC methods, to set specification limits and to document impurity profiles in ANDA and DMF submissions. Our customers for this product work in pharmaceutical manufacturing and academic and industrial research.

Vaqora Chemicals supplies 2,3,5-Trifluorophenylacetic acid in 10 mg, 25 mg, 50 mg and 100 mg packs, each shipped with a Certificate of Analysis (COA), and exports worldwide.

Typical applications

Analytical method development
Method validation (AMV)
QC release testing
ANDA / DMF filings

Industries

Related to Sitagliptin

View every impurity, metabolite and intermediate we list for Sitagliptin.

Sitagliptin impurities

Specifications & identifiers

Chemical identifiers
Product name	2,3,5-Trifluorophenylacetic acid
Catalogue No.	VQ-033889
CAS Number	132992-28-0
IUPAC name	2-(2,3,5-trifluorophenyl)acetic acid
Molecular formula	C₈H₅F₃O₂
Molecular weight	190.12 g/mol
Exact mass	190.0242
Grade	Reference Standard
HSN code	38229090
InChIKey	HHVKNKDKNBABCU-UHFFFAOYSA-N
SMILES	C1=C(C=C(C(=C1CC(=O)O)F)F)F
PubChem CID	2777946

Physical properties
Physical form	Solid
LogP (XLogP3)	1.7
H-bond donors / acceptors	1 / 5
TPSA	37.3 Å²
Synonyms	Benzeneacetic acid, 2,3,5-trifluoro-, 2,3,5-Trifluorobenzeneacetic acid, 2-(2,3,5-Trifluorophenyl)aceticacid, Benzeneacetic acid, 2,3,5-trifluo, (2,3,5-Trifluorophenyl)acetic acid, AldrichCPR

Safety & hazard information (GHS)

Harmful / irritant

Signal word: Warning

Hazard statements

H302Harmful if swallowed
H312Harmful in contact with skin
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation

Precautionary statements: P261, P264, P264 + P265, P270, P271, P280, P301 + P317, P302 + P352, P304 + P340, P305 + P351 + P338, P317, P319, P321, P330, P332 + P317, P337 + P317, P362 + P364, P403 + P233, P405, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of 2,3,5-Trifluorophenylacetic acid?

The CAS Registry Number of 2,3,5-Trifluorophenylacetic acid is 132992-28-0. It is also known as Benzeneacetic acid, 2,3,5-trifluoro-, 2,3,5-Trifluorobenzeneacetic acid, 2-(2,3,5-Trifluorophenyl)aceticacid.

What is the molecular formula and molecular weight of 2,3,5-Trifluorophenylacetic acid?

2,3,5-Trifluorophenylacetic acid has the molecular formula C8H5F3O2 and a molecular weight of 190.12 g/mol. Its IUPAC name is 2-(2,3,5-trifluorophenyl)acetic acid.

What is 2,3,5-Trifluorophenylacetic acid used for?

2,3,5-Trifluorophenylacetic acid is supplied as a characterised reference material related to Sitagliptin. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of 2,3,5-Trifluorophenylacetic acid can I order?

We supply 2,3,5-Trifluorophenylacetic acid in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with 2,3,5-Trifluorophenylacetic acid?

Yes. Every lot of 2,3,5-Trifluorophenylacetic acid is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can 2,3,5-Trifluorophenylacetic acid be shipped internationally?

Yes. 2,3,5-Trifluorophenylacetic acid is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.