3-(1,3-Dihydro-1-oxo-2H-isoindol-2-yl)-2,6-pi… 26581-81-7

Name: 3-(1,3-Dihydro-1-oxo-2H-isoindol-2-yl)-2,6-piperidinedione
Brand: Vaqora Chemicals
SKU: VQ-028320

About 3-(1,3-Dihydro-1-oxo-2H-isoindol-2-yl)-2,6-piperidinedione

Vaqora Chemicals supplies 3-(1,3-Dihydro-1-oxo-2H-isoindol-2-yl)-2,6-piperidinedione, an impurity of Thalidomide registered under CAS number 26581-81-7. Formula C13H12N2O3, molecular weight 244.25 g/mol. Systematically, it is named 3-(3-oxo-1H-isoindol-2-yl)piperidine-2,6-dione. Alternative names: 2-(2,6-dioxopiperidin-3-yl)phthalimidine and 2-(1-Oxo-2-isoindolinyl)glutarimide.

It is supplied as a solid. Keep the vial tightly closed, protected from light and humidity, at the temperature stated on the Certificate of Analysis. The GHS classification uses the signal word “Warning”, so appropriate gloves, eye protection and ventilation are recommended.

Pharmaceutical QC and development laboratories use this impurity standard of Thalidomide to develop and validate HPLC methods, to set specification limits and to document impurity profiles in ANDA and DMF submissions. Our customers for this product work in pharmaceutical manufacturing and academic and industrial research.

We offer 3-(1,3-Dihydro-1-oxo-2H-isoindol-2-yl)-2,6-piperidinedione in 10 mg, 25 mg, 50 mg and 100 mg packs with a batch-specific COA, and ship to customers worldwide.

Typical applications

Analytical method development
Method validation (AMV)
QC release testing
ANDA / DMF filings

Industries

Related to Thalidomide

View every impurity, metabolite and intermediate we list for Thalidomide.

Thalidomide impurities

Specifications & identifiers

Chemical identifiers
Product name	3-(1,3-Dihydro-1-oxo-2H-isoindol-2-yl)-2,6-piperidinedione
Catalogue No.	VQ-028320
CAS Number	26581-81-7
IUPAC name	3-(3-oxo-1H-isoindol-2-yl)piperidine-2,6-dione
Molecular formula	C₁₃H₁₂N₂O₃
Molecular weight	244.25 g/mol
Exact mass	244.0848
Grade	Reference Standard
HSN code	38229090
InChIKey	WENKGSGGXGQHSH-UHFFFAOYSA-N
SMILES	C1CC(=O)NC(=O)C1N2CC3=CC=CC=C3C2=O
PubChem CID	91585

Physical properties
Physical form	Solid
LogP (XLogP3)	0.2
H-bond donors / acceptors	1 / 3
TPSA	66.5 Å²
Synonyms	3-(1-oxo-2,3-dihydro-1H-isoindol-2-yl)piperidine-2,6-dione, 2-(2,6-dioxopiperidin-3-yl)phthalimidine, 2-(1-Oxo-2-isoindolinyl)glutarimide, Glutarimide, 2-(1-oxo-2-isoindolinyl)-, 3-(1,3-Dihydro-1-oxo-2H-isoindol-2-yl)-2,6-dioxopiperidine, 2-(2,6-dioxopiperidine-3-yl)phthalimidine, Phthalimidinoglutarimide, 3-(1-oxoisoindolin-2-yl)piperidine-2,6-dione, 2,6-Piperidinedione, 3-(1,3-dihydro-1-oxo-2H-isoindol-2-yl)-, EM-12, em12

Safety & hazard information (GHS)

Harmful / irritant

Signal word: Warning

Hazard statements

H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation

Precautionary statements: P261, P264, P264 + P265, P270, P271, P280, P301 + P317, P302 + P352, P304 + P340, P305 + P351 + P338, P319, P321, P330, P332 + P317, P337 + P317, P362 + P364, P403 + P233, P405, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of 3-(1,3-Dihydro-1-oxo-2H-isoindol-2-yl)-2,6-piperidinedione?

The CAS Registry Number of 3-(1,3-Dihydro-1-oxo-2H-isoindol-2-yl)-2,6-piperidinedione is 26581-81-7. It is also known as 3-(1-oxo-2,3-dihydro-1H-isoindol-2-yl)piperidine-2,6-dione, 2-(2,6-dioxopiperidin-3-yl)phthalimidine, 2-(1-Oxo-2-isoindolinyl)glutarimide.

What is the molecular formula and molecular weight of 3-(1,3-Dihydro-1-oxo-2H-isoindol-2-yl)-2,6-piperidinedione?

3-(1,3-Dihydro-1-oxo-2H-isoindol-2-yl)-2,6-piperidinedione has the molecular formula C13H12N2O3 and a molecular weight of 244.25 g/mol. Its IUPAC name is 3-(3-oxo-1H-isoindol-2-yl)piperidine-2,6-dione.

What is 3-(1,3-Dihydro-1-oxo-2H-isoindol-2-yl)-2,6-piperidinedione used for?

3-(1,3-Dihydro-1-oxo-2H-isoindol-2-yl)-2,6-piperidinedione is supplied as a characterised reference material related to Thalidomide. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of 3-(1,3-Dihydro-1-oxo-2H-isoindol-2-yl)-2,6-piperidinedione can I order?

We supply 3-(1,3-Dihydro-1-oxo-2H-isoindol-2-yl)-2,6-piperidinedione in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with 3-(1,3-Dihydro-1-oxo-2H-isoindol-2-yl)-2,6-piperidinedione?

Yes. Every lot of 3-(1,3-Dihydro-1-oxo-2H-isoindol-2-yl)-2,6-piperidinedione is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can 3-(1,3-Dihydro-1-oxo-2H-isoindol-2-yl)-2,6-piperidinedione be shipped internationally?

Yes. 3-(1,3-Dihydro-1-oxo-2H-isoindol-2-yl)-2,6-piperidinedione is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.