3-((3R,4R)-3-((7H-Pyrrolo[2,3-d]pyrimidin-4-y… 1527525-58-1

Name: 3-((3R,4R)-3-((7H-Pyrrolo[2,3-d]pyrimidin-4-yl)amino)-4-methylpiperidin-1-yl)-3-oxopropanenitrile
Brand: Vaqora Chemicals
SKU: VQ-028430

About 3-((3R,4R)-3-((7H-Pyrrolo[2,3-d]pyrimidin-4-yl)amino)-4-methylpiperidin-1-yl)-3-oxopropanenitrile

Vaqora Chemicals supplies 3-((3R,4R)-3-((7H-Pyrrolo[2,3-d]pyrimidin-4-yl)amino)-4-methylpiperidin-1-yl)-3-oxopropanenitrile, a metabolite or degradation product of Tofacitinib registered under CAS number 1527525-58-1. Its molecular formula is C15H18N6O and its molecular weight is 298.34 g/mol. The IUPAC name is 3-[(3R,4R)-4-methyl-3-(7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)piperidin-1-yl]-3-oxopropanenitrile. It is also known as Tofacitinib metabolite M1.

It is supplied as a solid. Store the standard in its sealed vial, protected from light and moisture, and follow the storage condition printed on the COA. Handle it with standard laboratory precautions and appropriate personal protective equipment.

It is used in metabolite identification, stability-indicating method development and impurity profiling of Tofacitinib, as well as in QC testing and ANDA/DMF documentation. It is used across pharmaceutical manufacturing and academic and industrial research.

Vaqora Chemicals supplies 3-((3R,4R)-3-((7H-Pyrrolo[2,3-d]pyrimidin-4-yl)amino)-4-methylpiperidin-1-yl)-3-oxopropanenitrile in 10 mg, 25 mg, 50 mg and 100 mg packs, each shipped with a Certificate of Analysis (COA), and exports worldwide.

Typical applications

Metabolite identification
Stability-indicating methods
Impurity profiling

Industries

Related to Tofacitinib

View every impurity, metabolite and intermediate we list for Tofacitinib.

Tofacitinib impurities

Specifications & identifiers

Chemical identifiers
Product name	3-((3R,4R)-3-((7H-Pyrrolo[2,3-d]pyrimidin-4-yl)amino)-4-methylpiperidin-1-yl)-3-oxopropanenitrile
Catalogue No.	VQ-028430
CAS Number	1527525-58-1
IUPAC name	3-[(3R,4R)-4-methyl-3-(7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)piperidin-1-yl]-3-oxopropanenitrile
Molecular formula	C₁₅H₁₈N₆O
Molecular weight	298.34 g/mol
Exact mass	298.1542
Grade	Reference Standard
HSN code	38229090
InChIKey	RINVSZVUBKMZHU-PWSUYJOCSA-N
SMILES	C[C@@H]1CCN(C[C@@H]1NC2=NC=NC3=C2C=CN3)C(=O)CC#N
PubChem CID	92135749

Physical properties
Physical form	Solid
LogP (XLogP3)	1.4
H-bond donors / acceptors	2 / 5
TPSA	97.7 Å²

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of 3-((3R,4R)-3-((7H-Pyrrolo[2,3-d]pyrimidin-4-yl)amino)-4-methylpiperidin-1-yl)-3-oxopropanenitrile?

The CAS Registry Number of 3-((3R,4R)-3-((7H-Pyrrolo[2,3-d]pyrimidin-4-yl)amino)-4-methylpiperidin-1-yl)-3-oxopropanenitrile is 1527525-58-1. It is also known as Tofacitinib metabolite M1.

What is the molecular formula and molecular weight of 3-((3R,4R)-3-((7H-Pyrrolo[2,3-d]pyrimidin-4-yl)amino)-4-methylpiperidin-1-yl)-3-oxopropanenitrile?

3-((3R,4R)-3-((7H-Pyrrolo[2,3-d]pyrimidin-4-yl)amino)-4-methylpiperidin-1-yl)-3-oxopropanenitrile has the molecular formula C15H18N6O and a molecular weight of 298.34 g/mol. Its IUPAC name is 3-[(3R,4R)-4-methyl-3-(7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)piperidin-1-yl]-3-oxopropanenitrile.

What is 3-((3R,4R)-3-((7H-Pyrrolo[2,3-d]pyrimidin-4-yl)amino)-4-methylpiperidin-1-yl)-3-oxopropanenitrile used for?

3-((3R,4R)-3-((7H-Pyrrolo[2,3-d]pyrimidin-4-yl)amino)-4-methylpiperidin-1-yl)-3-oxopropanenitrile is supplied as a characterised reference material related to Tofacitinib. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of 3-((3R,4R)-3-((7H-Pyrrolo[2,3-d]pyrimidin-4-yl)amino)-4-methylpiperidin-1-yl)-3-oxopropanenitrile can I order?

We supply 3-((3R,4R)-3-((7H-Pyrrolo[2,3-d]pyrimidin-4-yl)amino)-4-methylpiperidin-1-yl)-3-oxopropanenitrile in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with 3-((3R,4R)-3-((7H-Pyrrolo[2,3-d]pyrimidin-4-yl)amino)-4-methylpiperidin-1-yl)-3-oxopropanenitrile?

Yes. Every lot of 3-((3R,4R)-3-((7H-Pyrrolo[2,3-d]pyrimidin-4-yl)amino)-4-methylpiperidin-1-yl)-3-oxopropanenitrile is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can 3-((3R,4R)-3-((7H-Pyrrolo[2,3-d]pyrimidin-4-yl)amino)-4-methylpiperidin-1-yl)-3-oxopropanenitrile be shipped internationally?

Yes. We export 3-((3R,4R)-3-((7H-Pyrrolo[2,3-d]pyrimidin-4-yl)amino)-4-methylpiperidin-1-yl)-3-oxopropanenitrile worldwide by air and sea freight or express courier, on EXW, FOB, CIF, CFR or DAP Incoterms, with full export documentation.